公开(公告)号：EP1587508A1

公开(公告)日：2005-10-26

申请号：EP04707252.5

申请日：2004-02-02

申请人： Genfit

发明人： DARTEIL, Raphael ,  CAUMONT-BERTRAND, Karine ,  NAJIB, Jamila

IPC分类号： A61K31/25 ,  C07C323/52 ,  C07C327/28 ,  A61P9/10

CPC分类号： A61K31/045 ,  A61K31/22 ,  A61K31/25 ,  A61K31/265 ,  C07C323/52 ,  C07C327/28

摘要： The invention relates to the use of acylglycerols and the nitrogen- and sulphur-containing analogues thereof in therapy, particularly for the treatment of cerebral ischemia. The invention further relates to methods for preparation of said derivatives, novel compounds, in particular acylglycerols, the nitrogen- and sulphur-containing analogues thereof and methods for production thereof.

公开(公告)号：EP1525177A1

公开(公告)日：2005-04-27

申请号：EP03762749.4

申请日：2003-07-08

申请人： Genfit

发明人： NAJIB, Jamila ,  CAUMONT-BERTRAND, Karine

IPC分类号： C07C51/00 ,  C07C67/00 ,  C07C59/90 ,  C07C59/88 ,  C07C59/84 ,  C07C69/712 ,  C07C69/736 ,  C07C69/738 ,  C07C69/67 ,  C07C251/48 ,  C07C323/63 ,  C07C323/61 ,  C07C323/64 ,  C07C281/00 ,  C07C323/09

CPC分类号： C07C323/52 ,  C07C67/30 ,  C07C67/343 ,  C07C69/712 ,  C07C69/738 ,  C07C323/22

摘要： The invention concerns novel substituted 1,3-diphenylprop-2-en-1-one derivatives, pharmaceutical compositions comprising same, their therapeutic uses, in particular for treating cerebral ischemia. The invention also concerns a method for preparing said derivatives.

公开(公告)号：EP1519908A2

公开(公告)日：2005-04-06

申请号：EP03762750.2

申请日：2003-07-08

申请人： Genfit

发明人： NAJIB, Jamila ,  CAUMONT-BERTRAND, Karine

IPC分类号： C07C51/00 ,  C07C67/00 ,  C07C59/90 ,  C07C59/88 ,  C07C59/84 ,  C07C69/712 ,  C07C69/67 ,  C07C251/48 ,  C07C323/63 ,  C07C281/00 ,  C07C323/09 ,  C07D311/30 ,  A61K31/192 ,  A61K31/216 ,  A61P25/16 ,  A61P25/28 ,  A61P35/00 ,  A61P37/08 ,  A61P9/10 ,  A61P3/04 ,  A61P3/08

CPC分类号： A61K31/05 ,  A61K31/055 ,  A61K31/192 ,  A61K31/216 ,  C07C59/90 ,  C07C69/712 ,  C07C69/738 ,  C07C323/22 ,  C07C323/52

摘要： The invention concerns compositions comprising substituted 1,3-diphenylprop-2-en-1-one derivatives designed for therapeutic use. The inventive compositions are useful in particular for preventing or treating cardiovascular diseases, syndrome X, restenosis, diabetes, obesity, hypertension, inflammatory diseases, cancers or neoplasms (benign or malignant tumors), neurodegenerative, dermatological diseases and disorders related to oxidative stress and for example skin ageing, in particular in the field of cosmetics (occurrence of wrinkles and the like).

公开(公告)号：EP1311708A1

公开(公告)日：2003-05-21

申请号：EP01965340.1

申请日：2001-08-22

申请人： Genfit

发明人： STAELS, Bart ,  DELERIVE, Philippe

IPC分类号： C12Q1/68 ,  C12N15/63 ,  C12N15/85 ,  C12N5/10 ,  G01N33/566 ,  A61P29/00 ,  A61K31/00

CPC分类号： C12Q1/6897

摘要： The invention concerns a method for identifying substances useful for treating inflammation, characterised in that it comprises the following steps: (a) contacting said substance with a nucleic acid construct containing the response element to the ROR receptor of the promoter of the IλBα gene in conditions suitable for allowing said substance to be fixed on the response element; (b) measuring the possible fixing of said substance on the response element or the transcriptional activity of the response element or of a promoter containing it; (c) optionally comparing the measurement of step (b) with a measurement carried out in conditions similar to those of steps (a) and (b) but with a nucleic acid construct non containing the mutated response element.

公开(公告)号：EP3573960B1

公开(公告)日：2023-08-16

申请号：EP18701759.5

申请日：2018-01-29

发明人： DELHOMEL, Jean-François ,  PERSPICACE, Enrico ,  MAJD, Zouher ,  PARROCHE, Peggy ,  WALCZAK, Robert

IPC分类号： C07D265/36 ,  C07D215/48 ,  C07D241/52 ,  C07D209/34 ,  C07D209/38 ,  C07D231/56 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  A61K31/536 ,  A61K31/4725 ,  A61K31/498 ,  A61K31/454 ,  A61K31/425 ,  A61P37/00 ,  A61P37/06 ,  A61P37/08 ,  A61P31/00 ,  A61P19/02 ,  A61P11/06 ,  A61P1/04 ,  A61P1/16 ,  A61P3/00 ,  A61P3/10 ,  A61P9/00 ,  A61P9/10 ,  A61P11/00 ,  A61P13/12 ,  A61P17/00 ,  A61P17/06

公开(公告)号：EP3777854B1

公开(公告)日：2022-07-20

申请号：EP20194454.3

申请日：2017-03-13

发明人： DARTEIL, Raphaël ,  WALCZAK, Robert ,  BELANGER, Carole ,  NEGRO, Emilie ,  DAUBERSIES, Pierre ,  DELATAILLE, Philippe

IPC分类号： A61K31/426 ,  A61P1/16 ,  A61P11/00

公开(公告)号：EP3698377A2

公开(公告)日：2020-08-26

申请号：EP18786791.6

申请日：2018-10-19

申请人： Genfit

发明人： BROZEK, John ,  DEGALLAIX, Nathalie ,  NOEL, Benoît ,  REXHEPAJ, Elton

IPC分类号： G16H50/30 ,  G16H50/50 ,  G16H50/20 ,  G16H20/00

公开(公告)号：EP3585384A1

公开(公告)日：2020-01-01

申请号：EP18705945.6

申请日：2018-02-23

申请人： Genfit

发明人： DESCAMPS, Emeline ,  WALCZAK, Robert ,  BELANGER, Carole ,  NOEL, Benoît

IPC分类号： A61K31/4178 ,  A61K45/06 ,  A61K31/192

公开(公告)号：EP3237396B1

公开(公告)日：2019-07-03

申请号：EP15816802.1

申请日：2015-12-22

申请人： Genfit

发明人： DELHOMEL, Jean-François ,  WALCZAK, Robert ,  MAJD, Zouher ,  PIHAN, Emilie ,  BONNET, Pascal ,  PERSPICACE, Enrico

IPC分类号： C07D401/12 ,  C07D209/18 ,  C07D209/20 ,  A61K31/405 ,  A61K31/4709 ,  A61K31/4439 ,  A61P1/00 ,  A61P17/00 ,  A61P19/00 ,  A61P27/00 ,  A61P37/00 ,  A61P11/00 ,  C07D471/04 ,  C07D231/56

公开(公告)号：EP3350341A1

公开(公告)日：2018-07-25

申请号：EP16769923.0

申请日：2016-09-14

申请人： Genfit

发明人： DARTEIL, Raphaël ,  CORDONNIER, Geneviève ,  BROZEK, John ,  PRACA, Emilie ,  BEN SUDRIK, Fouad

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  A61K31/192 ,  A61P1/16 ,  C12Q2600/158 ,  C12Q2600/178 ,  G01N33/66 ,  G01N33/6893 ,  G01N33/723 ,  G01N2333/78 ,  G01N2333/8107 ,  G01N2800/085 ,  G01N2800/52

摘要： The invention relates to a method for the diagnosis of non-alcoholic steatohepatitis (NASH), for determining the activity, the stage, or the severity of NASH or for classifying a subject as a potential receiver or non receiver of a treatment of NASH using circulating miRNAs and other blood circulating markers of liver damage, e.g. alpha 2 macroglobulin, HbA1c, N-terminal pro-peptide of collagen type III, miR-34 and miR-200. It also relates to a kit for implementing the method of the invention, and the compounds for use in a method for the treatment of NASH, wherein the subject to be treated is identified, evaluated or classified according to the method of the invention.