公开(公告)号：EP4459376A3

公开(公告)日：2025-01-15

申请号：EP24200469.5

申请日：2021-12-22

Applicant: Shin-Etsu Chemical Co., Ltd.

Inventor： INOUE, Naoya ,  WATANABE, Satoshi ,  KOTAKE, Masaaki

IPC: C07C43/23 ,  C07C69/44 ,  C07C69/712 ,  C07C69/76 ,  C07C69/82 ,  C08L33/26 ,  C08L33/16 ,  G03F7/038

Abstract: A chemically amplified negative resist composition comprising an alcohol compound of specific structure as a crosslinker has a high sensitivity and dissolution contrast and forms a pattern of good profile with reduced values of LER and CDU.

公开(公告)号：EP4019489A1

公开(公告)日：2022-06-29

申请号：EP21216712.6

申请日：2021-12-22

Applicant: SHIN-ETSU CHEMICAL CO., LTD.

Inventor： INOUE, Naoya ,  WATANABE, Satoshi ,  KOTAKE, Masaaki

IPC: C07C43/23 ,  C07C69/44 ,  C07C69/712 ,  C07C69/76 ,  C07C69/82 ,  C08L33/26 ,  C08L33/16 ,  G03F7/038

Abstract: A chemically amplified negative resist composition comprising an alcohol compound of formula (AI) as a crosslinker, has a high sensitivity and dissolution contrast and forms a pattern of good profile with reduced values of LER and CDU.

公开(公告)号：EP4001251A1

公开(公告)日：2022-05-25

申请号：EP20841400.3

申请日：2020-07-13

Applicant: Honshu Chemical Industry Co., Ltd.

Inventor： SAKUMA, Daichi ,  SUTO, Takeru

IPC: C07C67/31 ,  C07C69/712

Abstract: An object is to provide a novel method for producing a binaphthyl, the method achieving good reaction efficiency and allowing an inorganic salt to be easily removed. As a solution, a method for producing a 2,2'-bis(alkoxycarbonylmethoxy)-1,1'-binaphthyl represented by formula (2), the method including reacting 1,1'-binaphthalene-2,2'-diol and a chloroacetic acid ester represented by formula (1) with each other in a C5 to C8 aliphatic ketone solvent in the presence of an alkali metal iodide, is provided.

公开(公告)号：EP3808731A1

公开(公告)日：2021-04-21

申请号：EP20213903.6

申请日：2014-10-24

Applicant: Insmed Incorporated

Inventor： MALININ, Vladimir ,  PERKINS, Walter ,  LEIFER, Franziska ,  KONICEK, Donna ,  LI, Zhili ,  PLAUNT, Adam

IPC: C07C69/712 ,  C07C235/20 ,  C07C235/22 ,  A61K31/165 ,  A61K31/19 ,  A61K31/216 ,  A61K31/225 ,  A61K47/54 ,  A61K47/60 ,  A61P9/12 ,  A61P11/00

Abstract: Prostacyclin compounds and compositions comprising the same are provided herein. Specifically, prostacyclin compounds comprising treprostinil covalently linked to a linear C 5 -C 18 alkyl, branched C 5 -C 18 alkyl, linear C 2 -C 18 alkenyl, branched C 3 -C 18 alkenyl, aryl, aryl-C 1 -C 18 alkyl or an amino acid or a peptide (e.g., dipeptide, tripeptide, tetrapeptide) are described. The linkage, in one embodiment, is via a carbamate, amide or ester bond. Prostacyclin compounds provided herein can also include at least one hydrogen atom substituted with at least one deuterium atom. Methods for treating pulmonary hypertension (e.g., pulmonary arterial hypertension) and portopulmonary hypertension are also provided.

公开(公告)号：EP3221291B1

公开(公告)日：2021-03-31

申请号：EP15862092.2

申请日：2015-11-18

Inventor： MALININ, Vladimir ,  PERKINS, Walter ,  LEIFER, Franziska ,  KONICEK, Donna M. ,  LI, Zhili ,  PLAUNT, Adam

IPC: C07C67/08 ,  C07C69/712

公开(公告)号：EP3712142A1

公开(公告)日：2020-09-23

申请号：EP20166678.1

申请日：2014-01-13

Applicant: Corsair Pharma, Inc.

Inventor： BECKER, Cyrus ,  RESCOURIO, Gwenaella ,  PFISTER, Jürg ,  VENKATRAMAN, Meenakshi ,  ZHANG, Xiaoming

IPC: C07D317/40 ,  C07D321/00 ,  C07D453/02 ,  C07D257/06 ,  C07D263/24 ,  C07D265/30 ,  C07D295/088 ,  C07D211/60 ,  C07D295/145 ,  C07D307/20 ,  C07C69/736 ,  C07C69/712 ,  C07C235/06 ,  C07C235/08 ,  C07C235/10 ,  C07C235/12

Abstract: Prodrugs of treprostinil are provided which can be used in the treatment of pulmonary hypertension (PH) or pulmonary arterial hypertension (PAH). The structures of the compounds can be adapted to the particular application for a suitable treatment dosage. Transdermal applications can be used.

公开(公告)号：EP3456715A1

公开(公告)日：2019-03-20

申请号：EP18202494.3

申请日：2016-06-14

Applicant: Corsair Pharma, Inc.

Inventor： ZHANG, Xiaoming ,  VENKATRAMAN, Meenakshi S. ,  BECKER, Cyrus K.

IPC: C07D309/08 ,  C07C69/28 ,  C07C69/63 ,  C07C69/708 ,  C07C69/712 ,  C07C69/74 ,  C07D305/08 ,  C07D307/30 ,  A61K31/335 ,  A61K31/222 ,  A61P9/12

Abstract: The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension.

公开(公告)号：EP3181545A1

公开(公告)日：2017-06-21

申请号：EP15842755

申请日：2015-09-15

Applicant: SHIONOGI & CO

Inventor： OKAMOTO KAZUYA ,  UENO TATSUHIKO ,  TOYOTA TAKASHI ,  SATOU YUUSUKE

IPC: C07C67/14 ,  C07B61/00 ,  C07C37/20 ,  C07C39/24 ,  C07C41/30 ,  C07C43/225 ,  C07C43/23 ,  C07C69/712 ,  C07C69/78

CPC classification number: C07C67/14 ,  C07B2200/13 ,  C07C37/20 ,  C07C37/68 ,  C07C41/26 ,  C07C41/30 ,  C07C67/29 ,  C07C67/31 ,  C07C69/734 ,  C07C69/736 ,  C07C69/78 ,  C07C39/373 ,  C07C43/23

Abstract: We provide a novel and useful process for preparing triphenyl-butene derivative. A process for the preparation of a compound represented by Formula (IV): wherein R 1 is hydrogen or substituted or unsubstituted alkyl, characterized by reacting a compound represented by Formula (V): with a compound represented by Formula (VI): wherein R 1 has the same meaning as defined above, in the presence of 1) a polyvalent metal chloride, 2) a reducing agent and 3) an alkali metal salt and / or a substituted or unsubstituted phenol.

Abstract translation: 我们提供了一种新颖而有用的制备三苯基丁烯衍生物的方法。 （IV）表示的化合物的制备方法：其中R 1为氢或取代或未取代的烷基，其特征在于使式（V）所示的化合物：与式（VI）所示的化合物反应：其中R 1具有与上述定义相同的含义，在1）多价金属氯化物，2）还原剂和3）碱金属盐和/或取代或未取代的苯酚存在下进行。

公开(公告)号：EP3169660A1

公开(公告)日：2017-05-24

申请号：EP14748380.4

申请日：2014-07-16

Applicant: Corsair Pharma, Inc.

Inventor： BECKER, Cyrus K. ,  RESCOURIO, Gwenaella ,  PFISTER, Jürg ,  VENKATRAMAN, Meenakshi ,  ZHANG, Xiaoming

IPC: C07C69/712 ,  C07D453/02 ,  C07D257/06 ,  C07D235/06 ,  C07D263/22 ,  C07D493/00 ,  C07D295/088 ,  C07D307/20 ,  C07C59/72 ,  A61K31/215 ,  A61K31/192 ,  A61K31/165 ,  A61K31/341 ,  A61P9/12

CPC classification number: C07C69/712 ,  C07C59/72 ,  C07C69/74 ,  C07C69/96 ,  C07C235/20 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/42 ,  C07C2603/14 ,  C07D211/60 ,  C07D257/06 ,  C07D263/26 ,  C07D265/30 ,  C07D295/145 ,  C07D317/24 ,  C07D321/00 ,  C07D323/00 ,  C07D453/02

Abstract: Compounds represented by formulae I, II, III, and IV including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (PH) or pulmonary arterial hypertension (PAH). The structures of the compounds can be adapted to the particular application for a suitable treatment dosage. Transdermal applications can be used.

Abstract translation: 由式I，II，III和IV表示的化合物包括曲前列环素和前列环素类似物的前药。 用途包括治疗肺动脉高压（PH）或肺动脉高压（PAH）。 化合物的结构可以适用于特定应用以获得合适的治疗剂量。 可以使用透皮应用。

公开(公告)号：EP2958148A1

公开(公告)日：2015-12-23

申请号：EP13875096.3

申请日：2013-08-21

Applicant: Japan Science and Technology Agency

Inventor： FUKUSHIMA, Takanori ,  SHOJI, Yoshiaki ,  ISHIWARI, Fumitaka ,  SEKITANI, Tsuyoshi ,  SOMEYA, Takao

IPC: H01L29/786 ,  C07C43/20 ,  C07C69/712 ,  H01L51/05 ,  H01L51/30

Abstract: The present invention provides a high-performance, highly homogeneous, highly stable electronic device by forming an extremely uniform interface between an insulator and an organic semiconductor, as well as an electronic apparatus using the same. The present invention relates to an electronic device which contains, as a component, an organic thin film in which a geometric two-dimensional arrangement is formed regularly by interdigitating skeletal structures of a positive three-pronged shape of triptycene and by adding a first molecule extending out of one plane of a two-dimensional molecular structure of the triptycene skeletal structure. The invention also relates to an electronic apparatus and the like which contains the electronic device in the interior of the electronic apparatus.

Abstract translation: 本发明提供一种高性能的，由上和有机半导体使用相同电子设备绝缘体之间极其均匀的界面，以及为形成高度均匀的，高度稳定的电子设备。 本发明涉及在其中含有的电子设备，作为有机薄膜的成分，其中A几何二维布置由相互交叉三蝶烯的正三结合形状的骨架结构和通过将第一分子扩展规则地形成 出三蝶烯骨架结构的二维分子结构中的一个平面之外。 因此，本发明涉及到电子装置并且其包含在电子装置内部的电子设备等。