公开(公告)号：EP1739186A1

公开(公告)日：2007-01-03

申请号：EP05727106.6

申请日：2005-03-23

申请人： HISAMITSU PHARMACEUTICAL CO., INC. ,  Chiba-Prefecture

发明人： NAKAGAWARA, Akira, Chiba Cancer Ctr Research Inst. ,  OZAKI, Toshifumi, Chiba Cancer Ctr Research Inst.

IPC分类号： C12Q1/02 ,  A61K38/00 ,  A61K48/00 ,  A61P35/00 ,  C12Q1/48 ,  G01N33/15 ,  G01N33/50 ,  C12N15/09

CPC分类号： G01N33/502 ,  A61K38/00 ,  C07K14/4747 ,  G01N33/5008 ,  G01N2510/00

摘要： A method for screening a pro-apoptotic compound comprising a determination step of determining a compound enhancing interaction between p73 and IKK-α as a pro-apoptotic compound.

摘要翻译： 一种用于筛选一个促凋亡化合物，其包含确定性采矿提高p73和IKK±之间的相互作用作为促凋亡化合物的化合物的确定步骤。

公开(公告)号：EP1726649A2

公开(公告)日：2006-11-29

申请号：EP06010000.5

申请日：2002-05-10

申请人： Juridical Foundation The Chemo-Sero-Therapeutic Research Institute ,  HISAMITSU PHARMACEUTICAL CO., INC.

发明人： HIRASHIMA, Masaki c/o Juridical Foundation The ,  NARUSE, Takeshi c/o Juridical Foundation The ,  MAEDA, Hiroaki c/o Juridical Foundation The ,  NOZAKI, Chikateru c/o Juridical Foundation The ,  GOTO, Takeshi c/o Hisamitsu Pharm. Co., Inc. ,  AKIYAMA, Katsuhiko c/o Hisamitsu Pharm. Co., Inc. ,  HATTORI, Wataru c/o Hisamitsu Pharm. Co., Inc.

IPC分类号： C12N15/09 ,  C07K14/47 ,  C12Q1/02

CPC分类号： C07K14/4747 ,  C07K14/47 ,  G01N33/5014

摘要： A peptide fragment or a series of peptide fragments containing one or more selenocysteine that has a lowered toxicity than selenocystine and that exhibits a cytotoxicity-inhibitory activity. The peptide fragment or a series of peptide fragments according to the present invention has preferably the amino acid sequence from 260th to 362nd amino acid residues from the C-terminal of selenoprotein P, or said amino acid sequence with one or several amino acid residues therein being deleted, substituted or added, or a partial sequence of either of the above amino acid sequences, or an amino acid sequence comprising as a part any of the above amino acid sequences. A screening method for a peptide fragment having the cytotoxicity-inhibitory activity is also provided.

公开(公告)号：EP1698330A1

公开(公告)日：2006-09-06

申请号：EP04807684.8

申请日：2004-12-24

申请人： HISAMITSU PHARMACEUTICAL CO. INC.

发明人： HASHIMOTO, Yoshiaki ,  TAKADA, Yasunori ,  SHINMURA, Miyuki ,  SUZUKI, Shigeo ,  TSURUDA, Kiyomi ,  IKESUE, Koichi

IPC分类号： A61K9/70 ,  A61K45/00 ,  A61K47/32 ,  A61K47/08 ,  A61K47/22 ,  A61K47/24 ,  A61K31/192 ,  A61P29/00

CPC分类号： A61K9/7053 ,  A61K9/0014 ,  A61K9/7038 ,  A61K9/7076 ,  A61K31/19 ,  A61K31/192

摘要： An adhesive patch comprising a substrate and a pressure-sensitive adhesive base, wherein the pressure-sensitive adhesive base comprises a rubbery polymer having double bonds in the main chain and a nonsteroidal anti-inflammatory analgesic and contains a UVA screening agent and/or UVB screening agent as a stabilizer for the rubbery polymer. The adhesive patch is excellent in the stability of the pressure-sensitive adhesive base and in drug infiltration into the skin.

摘要翻译： 一种粘合剂贴剂，其包含基材和压敏粘合剂基底，其中所述压敏粘合剂基底包含在主链中具有双键的橡胶状聚合物和非甾体抗炎止痛剂，并且含有UVA筛选剂和/或UVB筛选 作为橡胶状聚合物的稳定剂。 粘合剂贴剂在压敏粘合剂基质的稳定性和药物渗透到皮肤中是优异的。

公开(公告)号：EP1661560A1

公开(公告)日：2006-05-31

申请号：EP05077630.1

申请日：2005-11-21

申请人： HISAMITSU PHARMACEUTICAL CO., INC.

发明人： Yamaguchi, Toshiro c/o Hisamitsu Pharmaceutical Co ,  Kuribayashi, Mitsuru c/o Hisamitsu Pharmaceutical

IPC分类号： A61K9/70

CPC分类号： A61K9/7053 ,  A61K9/7061 ,  A61K47/12 ,  A61K47/14

摘要： The problem of the invention is to provide a drug-containing patch which is very favorable in percutaneous absorbability and is excellent in sustainability of the drug efficacy, that is, the drug-containing patch having a sufficient percutaneous absorbability and effect sustainability in a degree to be actually used for therapy of patients. The problem is solved by a patch comprising a drug, a melting point lowering agent and an adhesive base.

摘要翻译： 本发明的问题在于提供一种非常有利于经皮吸收性且药物功效的可持续性优异的药物补片，即具有足够的经皮吸收性的药物含有贴剂， 实际上用于治疗患者。 该问题通过包含药物，降粘剂和粘合剂基质的贴剂来解决。

公开(公告)号：EP1627644A1

公开(公告)日：2006-02-22

申请号：EP04734601.0

申请日：2004-05-24

申请人： HISAMITSU PHARMACEUTICAL CO. INC.

发明人： IKESUE, A., Tsukuba Hisamitsu Pharma. Co., Inc ,  YOSHITAKE, K., Tsukuba Hisamitsu Pharma. Co. Inc ,  ATARASHI, K., Tsukuba Hisamitsu Pharma Co. Inc. ,  IKESUE, K., Tsukuba HISAMITSUPharma Co. Inc ,  SAKAI, M., Tsukuba Hisamitsu Pharma co. Inc ,  REDDY, A., Ca. Lab. Hisamitsu Pharma co. inc ,  MOTOKI, Y., CA. Lab. Hisamitsu Pharma co. inc ,  VEERAPANENI, Dange

IPC分类号： A61K47/10 ,  A61K45/00 ,  A61K47/14 ,  A61K31/05 ,  A61K31/192 ,  A61K31/196 ,  A61K31/235 ,  A61K31/381 ,  A61K31/40 ,  A61K31/403 ,  A61K31/416 ,  A61K31/423 ,  A61K31/53 ,  A61K31/5415 ,  A61P17/00 ,  A61P29/00

CPC分类号： A61K31/196 ,  A61K9/0014 ,  A61K31/05 ,  A61K31/192 ,  A61K31/235 ,  A61K31/381 ,  A61K31/40 ,  A61K31/403 ,  A61K31/416 ,  A61K31/423 ,  A61K31/53 ,  A61K31/5415 ,  A61K45/06 ,  A61K47/10 ,  A61K47/14

摘要： A transdermal formulation for external application comprising a non-steroidal anti-inflammatory analgesic, an alkyl ester of gallic acid, and a phenolic radical scavenger having a branched-chain lower alkyl group.
An interleukin-1α production inhibitor consisting of a phenolic radical scavenger having a branched-chain lower alkyl group, and/or an alkyl ester of gallic acid.

摘要翻译： 透皮制剂用于外部施用，其包含非甾体类抗炎镇痛药，烷基没食子酸的酯，和具有支链的低级烷基的酚自由基清除剂。 白介素-1±产生抑制剂的酚自由基清除剂由具有支链的低级烷基，和/或没食子酸的烷基酯。

公开(公告)号：EP1611884A1

公开(公告)日：2006-01-04

申请号：EP04721660.1

申请日：2004-03-18

申请人： HISAMITSU PHARMACEUTICAL CO., INC.

发明人： TAKADA, Yasunori, Hisamitsu Pharmaceutical Co.,Inc ,  TANAKA, Koji, Hisamitsu Pharmaceutical Co., Inc. ,  TSURUDA, Kiyomi, Hisamitsu Pharmaceutical Co., Inc

IPC分类号： A61K31/192 ,  A61K31/196 ,  A61K31/407 ,  A61K9/70 ,  A61K47/12 ,  A61K47/34 ,  A61P29/00

CPC分类号： A61K31/192 ,  A61K9/7053 ,  A61K9/7076 ,  A61K31/196 ,  A61K31/407

摘要： An adhesive patch containing a non-steroidal anti-inflammatory agent, comprising a support and an adhesive layer laminated on this support, wherein the adhesive layer contains a non-steroidal anti-inflammatory agent having a carboxyl group or its salt, and polyethylene glycol having an average molecular weight of 1000 or more.

公开(公告)号：EP1147759B1

公开(公告)日：2005-11-16

申请号：EP00901968.8

申请日：2000-01-28

申请人： HISAMITSU PHARMACEUTICAL CO. INC.

发明人： MUTA, Kazunori, Hisamitsu Pharmaceutical Co., Inc. ,  KOSE, Yasuhisa, Hisamitsu Pharmaceutical Co., Inc. ,  OISHI, Shigehiro, Hisamitsu Pharmaceutical Co. Inc ,  HINOTANI, Tomoyuki, Hisamitsu Pharmaceut. Co., Inc

IPC分类号： A61K7/00 ,  A61K35/78

CPC分类号： A61K8/0212 ,  A61K8/97 ,  A61Q19/00 ,  A61Q19/10

摘要： Sheet-type packs which exert a skin cleansing effect while maintaining an effect of appropriately moistening the skin and are excellent in the feel in using and safety to the skin. In particular, sheet-type packs containing fruit extracts.

公开(公告)号：EP1477164A1

公开(公告)日：2004-11-17

申请号：EP03706968.9

申请日：2003-02-19

申请人： HISAMITSU PHARMACEUTICAL CO. INC.

发明人： Takada, Yasunori, Hisamitsu Pharmaceutical Co, Inc ,  Tanaka, Koji, Hisamitsu Pharmaceutical Co, Inc ,  Ikeura, Yasuhiro, Hisamitsu Pharmaceutical Co, Inc

IPC分类号： A61K9/70 ,  A61K47/32 ,  A61K31/196 ,  A61K47/12 ,  A61K47/14 ,  A61K47/34

CPC分类号： A61K9/7053 ,  A61K9/7076 ,  A61K31/196

摘要： A transdermal patch comprising a backing 2 and an adhesive layer 3 laminated on the backing 2, wherein the adhesive layer 3 comprises a rosin-based resin and petroleum resin as a tackifier, the total compounding amount of the rosin-based resin and the petroleum resin is in a range of 15 % by mass to 50 % by mass, and compounding amount of the petroleum resin is 1/3 times by mass to 4 times by mass as that of the rosin-based resin.

摘要翻译： 一种透皮贴剂，其包括层压在背衬2上的背衬2和粘合剂层3，其中粘合剂层3包含松香类树脂和作为增粘剂的石油树脂，松香类树脂和石油树脂的总配混量 在15质量％〜50质量％的范围内，石油树脂的混合量为松香系树脂的1/3质量倍〜4质量倍。

公开(公告)号：EP0847775B1

公开(公告)日：2004-10-27

申请号：EP96926634.5

申请日：1996-08-12

申请人： HISAMITSU PHARMACEUTICAL CO. INC.

发明人： MORI, Kenji c/o Tskuuba Laboratory ,  NAKAMURA, Katsuhiro c/o Tsukuba Laboratory ,  HIGO, Naruhito c/o Tsukuba Laboratory ,  KUZUMAKI, Noriyuki c/o Tsukuba Laboratory

IPC分类号： A61N1/30 ,  A61N1/32

CPC分类号： A61N1/044 ,  A61N1/0436 ,  A61N1/0448 ,  A61N1/325

摘要： An iontophoresis device which is capable of reducing variations in drug delivery caused by the individual difference in the impedances of the skin or mucous membrane and inhibiting a decrease in drug delivery at a different electrode and is excellent in pharmacological effects, safety, reliability, and mass-producibility. The device comprises a different electrode, an indifferent electrode, a current detection section for determining an active current value as a difference between the value of an applied current flowing between the different and indifferent electrodes when pulse voltage/current are applied and the value of a discharge current flowing when the electric charge accumulated in the living organism is discharged as a result of short-circuiting in the different and indifferent electrodes occurring when the application of pulse voltage/current is suspended, and a feedback control section for controlling the active current value by making pulse voltage/current amplitudes variable. The method of current control for the device comprises the step of determining the active current value and the feedback control step for controlling the active current value.

公开(公告)号：EP1426443A1

公开(公告)日：2004-06-09

申请号：EP02762836.1

申请日：2002-08-23

申请人： HISAMITSU PHARMACEUTICAL CO. INC. ,  Chiba-Prefecture

发明人： NAKAGAWARA, Akira, Chiba Cancer Center Res. Inst ,  HATTORI, Masahira ,  SAKAKI, Yoshiyuki

IPC分类号： C12N15/12 ,  C07K14/47

CPC分类号： C07K14/47

摘要： Human BMCC1 protein having an amino acid sequence set forth in SEQ ID NO:1 in the Sequence Listing and its variant protein, as well as human BMCC1 gene having a base sequence set forth in SEQ ID NO:2 in the Sequence Listing and its variant gene.

摘要翻译： 具有序列表中SEQ ID NO：1所示的氨基酸序列及其变体蛋白质的人BMCC1蛋白质，以及具有序列表的序列号2所示的碱基序列的人BMCC1基因及其变体 基因。