摘要:
An adhesive preparation comprising a stretchable support and an adhesive layer laminated on at least one side of the support, wherein the stretchable support comprises a interlock woven fabric subjected to crimping processing, the adhesive layer contains 10% by mass or more of methyl salicylate with respect to the total mass of the layer, the whole adhesive preparation has moisture permeability of 1 to 350 g/m 2 ·24 hr measured at a temperature of 40°C and a relative humidity of 90%, and the methyl salicylate has a plasma AUC 0-24 ranging from 3.0 to 60.0 ng·hr/mL in terms of a mean ± standard deviation, and salicylic acid as a metabolite of the methyl salicylate has a plasma AUC 0-24 ranging from 5000 to 13000 ng·hr/mL in terms of a mean ± standard deviation, when the adhesive preparation is applied to a human skin for 8 hours such that an application amount of the adhesive layer applied is 50 to 300 g/m 2 and a contact area is 280 cm 2 .
摘要翻译:一种粘合剂制剂,包括层压在所述载体的至少一侧上的可拉伸载体和粘合剂层,其中所述可拉伸载体包括进行压接加工的互锁织物,所述粘合剂层包含10质量%以上的水杨酸甲酯, 对于该层的总质量,整个粘合剂制剂在40℃和相对湿度为90%的温度下测得的透湿度为1至350g / m 2·24小时,水杨酸甲酯具有血浆AUC 0-24范围为3.0〜60.0ng·hr / mL,平均±标准偏差,作为水杨酸甲酯代谢物的水杨酸的血浆AUC 0-24为5000〜13000ng·hr / mL, 当将粘合剂制剂施用于人类皮肤8小时,使得施加的粘合剂层的涂布量为50-300g / m 2,接触面积为280cm 2时,平均±标准偏差的术语。
摘要:
An adhesive patch comprising a substrate and a pressure-sensitive adhesive base, wherein the pressure-sensitive adhesive base comprises a rubbery polymer having double bonds in the main chain and a nonsteroidal anti-inflammatory analgesic and contains a UVA screening agent and/or UVB screening agent as a stabilizer for the rubbery polymer. The adhesive patch is excellent in the stability of the pressure-sensitive adhesive base and in drug infiltration into the skin.
摘要:
An adhesive comprising a base with tackiness, an oil and ketoprofen, wherein the adhesive contains no L-menthol, the base is composed at least of a tacky composition comprising an elastomer and a tackifier and/or a tacky polymer containing an unsaturated monomer with a total of 5 or more carbon atoms as the monomer unit, the oil is an oil that is compatible with the tacky composition and the tacky polymer, and the oil content is 150-175 parts by weight with respect to 100 parts by weight as the total of the tacky composition and the tacky polymer.
摘要:
A transdermal preparation for external use which contains a photosensitive NSAID and a UV blocker having a high ability to migrate into the skin. Thus, it becomes possible to ensure, in a transdermal preparation for external use containing a NSAID, the inhibition of the onset of light-induced non-immunological or immunological skin symptoms by the above-described component.
摘要:
A conventional medicated patch containing an anti-inflammatory agent causes a dermatitis or the like on rare occasion by excess irradiation with light. For overcoming the problem, a medicated patch is provided, which comprises an anti-inflammatory agent, BM-DBM as an ultraviolet absorber, and hexyl laurate as an agent for accelerating the migration of the ultraviolet absorber into the skin in an adhesive base material thereof.
摘要:
An adhesive comprising a base with tackiness, an oil and ketoprofen, wherein the adhesive contains no L-menthol, the base is composed at least of a tacky composition comprising an elastomer and a tackifier and/or a tacky polymer containing an unsaturated monomer with a total of 5 or more carbon atoms as the monomer unit, the oil is an oil that is compatible with the tacky composition and the tacky polymer, and the oil content is 150-175 parts by weight with respect to 100 parts by weight as the total of the tacky composition and the tacky polymer.