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公开(公告)号：EP2842942B1
公开(公告)日：2016-12-07
申请号：EP13781244.2
申请日：2013-04-26
发明人： IINUMA, Munekazu , FURUKAWA, Shoei , NAIKI, Mitsuru , MATSUMOTO, Tomonori , HIGASHIURA, Kunihiko
IPC分类号： C07D207/16 , A61K9/70 , A61K31/40 , A61K31/401 , A61K31/426 , A61K31/445 , A61K31/4453 , A61K31/495 , A61K31/496 , A61K31/506 , A61K31/5375 , A61K31/54 , A61K31/55 , A61K31/551 , A61K47/40 , A61P19/02 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/16 , A61P25/22
CPC分类号： C07D295/185 , C07D207/08 , C07D207/16 , C07D211/16 , C07D211/18 , C07D211/26 , C07D211/30 , C07D211/44 , C07D211/46 , C07D211/48 , C07D211/58 , C07D211/62 , C07D211/74 , C07D213/74 , C07D239/42 , C07D243/08 , C07D277/04 , C07D295/18
摘要： The present invention relates to a novel trans-2-decenoic acid derivative or a pharmaceutically acceptable salt thereof, and a pharmaceutical agent containing the compound as an active ingredient. The trans-2-decenoic acid derivative or a pharmaceutically acceptable salt, which is the compound of the present invention, is specifically represented by the general formula (I): wherein X is a substituent such as a 1-pyrrolidyl, a 3-thiazolizyl, or a piperidino, and the compound is highly useful as a pharmaceutical agent, such as a prophylactic or therapeutic agent for a peripheral nerve disorder induced by administration of an anticancer agent, a prophylactic or therapeutic agent for neurodegenerative diseases or mental diseases such as dementia, Alzheimer's diasease, Parkinson's disease, diabetic neuropathy, depression, glaucoma, or autistic disorder spectrum, a therapeutic or repairing agent for spinal cord injury, analgesics against various pain diseases, or the like.
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62.发明授权AMELIORATING OR THERAPEUTIC AGENT FOR CHRONIC PROSTATITIS, INTERSTITIAL CYSTITIS AND/OR URINATION DISORDERS 有权手段救济或慢性前列腺炎愈合，间质性膀胱炎或膀胱功能障碍
公开(公告)号：EP2545929B1
公开(公告)日：2016-11-02
申请号：EP11753428.9
申请日：2011-03-10
发明人： TAMAKI, Makoto
CPC分类号： A61K35/36 , A61K2039/515
摘要： The purpose of the present invention is to provide a medicinal agent which is useful for amelioration or treatment of chronic prostatitis, Interstitial cystitis and/or urination disorders. The present invention relates to a novel medical use of an extract from inflamed tissues inoculated with vaccinia virus, and more particularly, it relates to an ameliorating or therapeutic agent for chronic prostatitis, interstitial cystitis and/or urination disorders containing the extract as an active ingredient. The medicinal agent of the present invention containing the extract as an active ingredient is extremely useful as a highly effective and highly safe ameliorating or therapeutic agent for chronic prostatitis, interstitial cystitis and/or urination disorders.
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63.发明公开
公开(公告)号：EP2992889A1
公开(公告)日：2016-03-09
申请号：EP14791811.4
申请日：2014-04-30
摘要： An object of the present invention is to provide an extract from inflamed skins of rabbits inoculated with vaccinia virus where the quality of the extract is more stabilized and also to provide a preparation, etc. containing said extract as an active ingredient.
When the amount of sulfated tyrosine contained in an extract from inflamed skins of rabbits inoculated with vaccinia virus and also contained in a preparation containing said extract as an active ingredient is used as an index, the quality of the extract and the preparation among the manufacturing lots can be warranted as a more stabilized one. In the extract from inflamed skins of rabbits inoculated with vaccinia virus and the preparation containing said extract where the quality thereof is more stabilized by such a method, the efficacy and the safety thereof are now guaranteed more strictly resulting in very high usefulness.摘要翻译： 本发明的目的是提供一种用痘苗病毒接种的兔子的发炎皮肤的提取物，其中提取物的质量更稳定，并且还提供含有所述提取物作为活性成分的制剂等。 当用痘苗病毒接种的兔子的发炎皮肤提取物中所含的硫酸化酪氨酸含量也用作含有所述提取物作为有效成分的制剂时，提取物的质量和制造批次之间的制备 可以作为更稳定的一个。 在用痘苗病毒接种的兔子的发炎皮肤的提取物中，通过这种方法使其含有更稳定的含有所述提取物的制剂的制剂的效果和安全性得到更严格的保证，从而实现非常高的用途。
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公开(公告)号：EP2460803B1
公开(公告)日：2016-01-13
申请号：EP10804378.7
申请日：2010-07-26
IPC分类号： C07D409/04
CPC分类号： C07D409/04
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公开(公告)号：EP2940003A1
公开(公告)日：2015-11-04
申请号：EP13868904.7
申请日：2013-12-27
IPC分类号： C07C233/22 , A61K31/165 , A61K31/40 , A61K31/4045 , A61K31/415 , A61K31/4174 , A61K31/4192 , A61K31/4196 , A61K31/42 , A61K31/4402 , A61K31/495 , A61P25/04 , C07D207/335 , C07D209/14 , C07D213/40 , C07D231/12 , C07D231/56 , C07D233/64 , C07D235/06 , C07D249/04 , C07D261/08
CPC分类号： C07D295/13 , C07C233/40 , C07C233/51 , C07C279/12 , C07C2601/14 , C07D207/335 , C07D209/14 , C07D209/16 , C07D213/40 , C07D231/12 , C07D231/56 , C07D233/64 , C07D235/06 , C07D249/04 , C07D249/08 , C07D261/08 , C07D295/12
摘要： The present invention provides a cinnamic acid amide derivative having an excellent analgesic action. The cinnamic acid amide derivative of the present invention is a compound showing excellent analgesic actions to not only a nociceptive pain model animal but also a neuropathic pain model animal, which is very useful as an agent for treating various pain diseases showing acute or chronic pains or neuropathic pains.
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公开(公告)号：EP2119444B1
公开(公告)日：2015-07-08
申请号：EP08704491.3
申请日：2008-02-06
发明人： NAKAZAWA, Yoshitaka
IPC分类号： A61K31/7012 , A61P25/04 , C07H7/027
CPC分类号： A61K31/7012 , C07H7/027
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公开(公告)号：EP2842942A1
公开(公告)日：2015-03-04
申请号：EP13781244.2
申请日：2013-04-26
发明人： IINUMA, Munekazu , FURUKAWA, Shoei , NAIKI, Mitsuru , MATSUMOTO, Tomonori , HIGASHIURA, Kunihiko
IPC分类号： C07D207/16 , A61K9/70 , A61K31/40 , A61K31/401 , A61K31/426 , A61K31/445 , A61K31/4453 , A61K31/495 , A61K31/496 , A61K31/506 , A61K31/5375 , A61K31/54 , A61K31/55 , A61K31/551 , A61K47/40 , A61P19/02 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/16 , A61P25/22
CPC分类号： C07D295/185 , C07D207/08 , C07D207/16 , C07D211/16 , C07D211/18 , C07D211/26 , C07D211/30 , C07D211/44 , C07D211/46 , C07D211/48 , C07D211/58 , C07D211/62 , C07D211/74 , C07D213/74 , C07D239/42 , C07D243/08 , C07D277/04 , C07D295/18
摘要： The present invention relates to a novel trans-2-decenoic acid derivative or a pharmaceutically acceptable salt thereof, and a pharmaceutical agent containing the compound as an active ingredient. The trans-2-decenoic acid derivative or a pharmaceutically acceptable salt, which is the compound of the present invention, is specifically represented by the general formula (I):
wherein X is a substituent such as a 1-pyrrolidyl, a 3-thiazolizyl, or a piperidino, and the compound is highly useful as a pharmaceutical agent, such as a prophylactic or therapeutic agent for a peripheral nerve disorder induced by administration of an anticancer agent, a prophylactic or therapeutic agent for neurodegenerative diseases or mental diseases such as dementia, Alzheimer's diasease, Parkinson's disease, diabetic neuropathy, depression, glaucoma, or autistic disorder spectrum, a therapeutic or repairing agent for spinal cord injury, analgesics against various pain diseases, or the like.摘要翻译： 本发明涉及新型反式-2-癸烯酸衍生物或其药学上可接受的盐以及含有该化合物作为活性成分的药剂。 作为本发明化合物的反式-2-癸烯酸衍生物或其药学上可接受的盐具体由通式（I）表示：其中X是取代基，例如1-吡咯烷基，3-噻唑基 或哌啶子基，该化合物作为抗癌剂的给药诱导的周围神经障碍的预防或治疗剂，神经变性疾病的预防或治疗剂或痴呆等精神疾病的药剂非常有用 ，阿尔茨海默氏病，帕金森病，糖尿病性神经病，抑郁症，青光眼或自闭症谱，脊髓损伤的治疗剂或修复剂，针对各种疼痛疾病的镇痛剂等。
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68.发明公开METHOD FOR DETERMINATION OR EVALUATION OF SUBSTANCE OF INTEREST 有权VERFAHREN ZUR BESTIMMUNG ODER AUSWERTUNG EINER TESTSUBSTANZ
公开(公告)号：EP2587265A1
公开(公告)日：2013-05-01
申请号：EP11798198.5
申请日：2011-06-23
发明人： MUTOH, Tatsuro , FUKUDA, Yu
CPC分类号： C12Q1/6876 , G01N33/5023 , G01N33/5041 , G01N33/6854 , G01N2333/07
摘要： An object of the present invention is to provide a method for determination or evaluation of an extract from inflamed tissues inoculated with vaccinia virus where the enhancement of activation of neurotrophic factor such as BDNF in cultured cells or the enhancement of activation of proteins participating therein is used as an indicator.
The present invention relates to a novel method for determination or evaluation of an extract from inflamed tissues inoculated with vaccinia virus and relates to a method for determination or evaluation of the extract where the enhancement of production of neurotrophic factor such as BDNF in cultured cells or the enhancement of activation of various proteins in intracellular signaling pathway participating in production of BDNF, etc. is used as an indicator.
The present invention is highly useful as a simple, convenient and quick method for determination or evaluation for guaranteeing the quality of the extract which is useful as a pharmaceutical agent.摘要翻译： 本发明的目的是提供一种用于确定或评估接种痘苗病毒的发炎组织的提取物的方法，其中使用培养细胞中增强神经营养因子如BDNF的活化或者使用其中参与蛋白质的活化的增强 作为指标。 本发明涉及一种用于确定或评估接种痘苗病毒的发炎组织的提取物的新方法，涉及一种用于测定或评估提取物的方法，其中增强培养细胞中BDNF等神经营养因子的产生，或 使用参与BDNF生产的细胞内信号通路中的各种蛋白质的活化增强作为指标。 本发明作为用于确定或评估用于确保作为药剂有用的提取物的质量的简单，方便和快速的方法是非常有用的。
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69.发明授权PROPHYLACTIC OR ALLEVIATING AGENT FOR PERIPHERAL NERVE DISORDER INDUCED BY ANTI-CANCER AGENT 有权预防或镇痛剂为罹患PEIPHEREN神经系统继抗癌药物
公开(公告)号：EP2191836B1
公开(公告)日：2012-05-23
申请号：EP08828811.3
申请日：2008-08-28
发明人： OISHI, Ryozo , ITOH, Yoshinori , EGASHIRA, Nobuaki
CPC分类号： A61K35/36 , A61K35/76 , C12N2710/24132 , A61K2300/00
摘要： There is provided a medicinal agent that is effective and highly safe for the prevention or alleviation of a peripheral nerve disorder that develops as a side effect occurring after the administration of an anti-cancer agent. The present invention relates to a novel medical use of an extract from inflamed tissues inoculated with vaccinia virus, and to a prophylactic or alleviating agent for a peripheral nerve disorder that contains the extract as an active ingredient. The agent containing the extract as an active ingredient is used for a prophylactic or alleviating agent for a peripheral nerve disorder induced by an anti-cancer agent and is a highly safe and remarkably highly useful medicinal agent with few side effects.
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公开(公告)号：EP2003122B1
公开(公告)日：2011-12-07
申请号：EP08015840.5
申请日：2003-04-09
发明人： Okamoto, Kaoru , Nishimura, Naoharu , Ishii, Akira
IPC分类号： C07D233/72 , A61K31/415 , A61P13/12
CPC分类号： C07D233/72
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