公开(公告)号：EP2636666B1

公开(公告)日：2018-01-10

申请号：EP11838046.8

申请日：2011-11-01

申请人： Nagoya Industrial Science Research Institute ,  Nippon Zoki Pharmaceutical Co., Ltd.

发明人： IINUMA, Munekazu ,  FURUKAWA, Shoei ,  NAIKI, Mitsuru ,  MATSUMOTO, Tomonori ,  SUGIMOTO, Hachiro

IPC分类号： C07C219/20 ,  A61K31/165 ,  A61K31/231 ,  A61K31/255 ,  A61K31/40 ,  A61P25/02 ,  A61P25/14 ,  A61P25/28 ,  A61P43/00 ,  C07C217/08 ,  C07C233/09 ,  C07C233/38 ,  C07C327/30 ,  C07C327/22 ,  C07D295/13 ,  C07C69/533 ,  C07C323/12

CPC分类号： C07C327/30 ,  A61K31/231 ,  C07C57/02 ,  C07C69/533 ,  C07C217/08 ,  C07C219/08 ,  C07C219/20 ,  C07C233/09 ,  C07C233/38 ,  C07C323/12 ,  C07C327/22 ,  C07C2601/08 ,  C07C2601/14 ,  C07D295/13

摘要： An object of the present invention is to provide a novel trans-2-decenoic acid derivative or a pharmaceutically acceptable salt thereof and to provide a pharmaceutical agent which contains said compound as an active ingredient and has a highly safe neurotrophic factor-like activity or an alleviating action for side effect induced by administration of anti-cancer agents. The trans-2-decenoic acid derivative or a pharmaceutically acceptable salt thereof which is the compound of the present invention is specifically represented by the formula (1): (In the formula, Y is -O-, -NR- or -S-, R is hydrogen atom, alkyl group, dialkylaminoalkyl group or the like and W is a substituent such as dialkylaminoalkyl group) and has a quite high usefulness as a pharmaceutical agent such as a preventive or therapeutic agent for dementia, Alzheimer's disease, Parkinson's disease, depression, etc., a treating or repairing agent for spinal cord injury or an alleviating agent for side effect induced by administration of anti-cancer agents.

公开(公告)号：EP2457567B1

公开(公告)日：2015-12-30

申请号：EP12156315.9

申请日：2008-09-18

申请人： Nagoya Industrial Science Research Institute ,  Nippon Zoki Pharmaceutical Co., Ltd.

发明人： Iinuma, Munekazu ,  Furukawa, Shoei

IPC分类号： A61K31/20 ,  A61K31/201 ,  A61K31/23 ,  A61K31/231 ,  A61P21/02 ,  A61P25/00 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/22 ,  A61P25/24

CPC分类号： A61K31/20 ,  A61K31/201 ,  A61K31/23 ,  A61K31/231

公开(公告)号：EP2255788B1

公开(公告)日：2015-07-22

申请号：EP09714964.5

申请日：2009-02-26

申请人： Nagoya Industrial Science Research Institute

发明人： HARA, Hideaki ,  TAKEUCHI, Hirofumi

IPC分类号： A61K9/127 ,  A61K47/24 ,  A61K47/28 ,  A61P27/02

CPC分类号： A61K9/0048 ,  A61K9/1272 ,  A61K31/00

公开(公告)号：EP2695613A1

公开(公告)日：2014-02-12

申请号：EP12742101.4

申请日：2012-01-30

申请人： Nippon Zoki Pharmaceutical Co., Ltd. ,  Nagoya Industrial Science Research Institute

发明人： IINUMA, Munekazu ,  FURUKAWA, Shoei ,  NAIKI, Mitsuru ,  OKADA, Tomoyuki ,  MATSUMOTO, Tomonori ,  SAWADA, Kazuyoshi

IPC分类号： A61K31/201 ,  A61P29/00

CPC分类号： A61K31/23 ,  A61K31/231

摘要： An object of the present invention is to provide an analgesic effective in a prophylactic or a therapy for various pain diseases. The present invention is to provide an analgesic containing an ester of C 10 fatty acid as an active ingredient. The analgesic of the present invention containing the compound as an active ingredient is highly useful as a prophylactic or therapeutic agent for various pain diseases such as the pain caused by osteoarthritis (e.g., knee osteoarthritis and hip osteoarthritis) or by demyelinating diseases such as multiple sclerosis or Guillain-Bareé syndrome.

摘要翻译： 本发明的目的是提供对各种疼痛疾病的预防或治疗有效的止痛剂。 本发明提供含有C10脂肪酸酯作为有效成分的镇痛剂。 含有该化合物作为有效成分的本发明的镇痛剂作为各种疼痛疾病的预防或治疗剂非常有用，所述疼痛疾病诸如由骨关节炎（例如膝骨关节炎和髋关节骨关节炎）引起的疼痛或通过脱髓鞘疾病如多发性硬化症 或格林 - 巴利综合征。

公开(公告)号：EP1813621B1

公开(公告)日：2011-06-08

申请号：EP05795713.6

申请日：2005-10-24

申请人： Nagoya Industrial Science Research Institute ,  Kanto Kagaku Kabushiki Kaisha

发明人： OHKUMA, Takeshi Verudomiru-Soen 2-401 ,  SANDVAL, Christian A. c/o Shanghai Institute of Org. Chemistry ,  NOYORI, Ryoji

IPC分类号： C07F9/50 ,  C07B53/00 ,  C07C29/145 ,  C07C31/125 ,  C07C33/20 ,  C07C33/30 ,  C07C35/08 ,  C07C67/29 ,  C07C69/24 ,  C07D213/73 ,  C07D307/44 ,  C07D333/16 ,  C07B61/00 ,  C07F15/00

CPC分类号： C07D213/73 ,  C07B53/00 ,  C07C29/145 ,  C07C67/31 ,  C07F15/0053 ,  C07C31/125 ,  C07C69/675 ,  C07C69/732

摘要： Pinacolone being a tert-alkyl ketone is hydrogenated by pressurized hydrogen in the presence of ruthenium complex (S)-1 and a base, thereby obtaining corresponding (S)-3,3-dimethyl-2-butanol with 100% yield, 97%ee.

公开(公告)号：EP1566555B1

公开(公告)日：2008-02-27

申请号：EP03812279.2

申请日：2003-10-22

申请人： Kabushiki Kaisha Imasen Denki Seisakusho ,  Nagoya Industrial Science Research Institute

发明人： FUJII, Hiroshi ,  SUGIYAMA, Katsuhiro, c/o Kabushiki Kaisha Imasen ,  MITSUKUCHI, Masashi, c/o Kabushiki Kaisha Imasen ,  KATAYAMA, Kenichi, c/o Kabushiki Kaisha Imasen ,  MORIGUCHI, Yoshinori, c/o Kabushiki Kaisha Imasen

IPC分类号： F16B39/30 ,  F16H25/24

CPC分类号： F16B33/02 ,  F16B39/30 ,  F16H25/2454

摘要： Flat portions (12a) and inclined portions (12b) are alternately provided on a thread (12) of a multi-pitch screw (10). Flat portions and inclined portions are also provided on a thread of a multi-pitch nut that is screwed on the multi-pitch screw (10). These realize a screw and nut that reliably achieve loosening prevention in a stepping manner. The screw and nut enable smooth high-speed feeding. Self-locking works in a stepping manner even if torque from a drive source is cut out.

公开(公告)号：EP1574571A1

公开(公告)日：2005-09-14

申请号：EP03812352.7

申请日：2003-12-01

申请人： Nagoya Industrial Science Research Institute

发明人： YOSHIOKA, Hirofumi

IPC分类号： C12N15/11 ,  C12N15/82 ,  A01H5/00

CPC分类号： C12N15/8279 ,  C12N15/8239 ,  C12N15/8281

摘要： It is intended to provide a promoter responding specifically to germ infection ( i.e. germ-responsive promoter). Namely, a germ-responsive promoter containing DNA comprising the PVS3 promoter region (SEQ ID NO:1) of potato plant. A region (SEQ ID NO:23) being important in the promoter activity.

摘要翻译： 旨在提供特异性响应胚芽感染的启动子（即，胚发生反应性启动子）。 即，含有包含马铃薯植物的PVS3启动子区（SEQ ID NO：1）的DNA的胚发生启动子启动子。 在启动子活性中重要的区域（SEQ ID NO：23）。

公开(公告)号：EP1548114A1

公开(公告)日：2005-06-29

申请号：EP03788072.1

申请日：2003-08-11

申请人： KANEKA CORPORATION ,  Nagoya Industrial Science Research Institute

发明人： IIJIMA, Shinji ,  KAMIHIRA, Masamichi, 603, Takaramanshonshirokicho ,  NISHIJIMA, Kenichi, 302, Kuzuokamanshon ,  ONO, Kenichiro

IPC分类号： C12N15/13 ,  C12P21/02 ,  C07K16/00 ,  A01K67/027

CPC分类号： A01K67/0275 ,  A01K67/0278 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/05 ,  A01K2227/30 ,  A01K2267/01 ,  C07K16/02 ,  C07K16/2806 ,  C07K2317/21 ,  C07K2317/52 ,  C07K2317/622 ,  C07K2319/00 ,  C12N15/8509 ,  C12N2799/027 ,  C12N2830/00 ,  C12N2830/15 ,  C12N2830/60 ,  C12N2830/90 ,  C12N2840/20 ,  C12N2840/203

摘要： The present invention has for its object to provide a G0 transgenic chimera bird which is introduced an antibody gene with a replication-defective retrovirus vector, and produces an antibody by expressing the transgene; a production method of an antibody which comprises recovering the antibody expressed by the produced G0 transgenic chimera bird; and a production method of a G0 transgenic chimera bird which comprises incubating a bird fertile egg, and injecting an embryo after and exclusive of a period immediately after the start of incubation with a retrovirus vector.
That is, the present invention relates to a G0 transgenic chimera bird which is introduced an antibody gene with a replication-defective retrovirus vector, and produces an antibody by expressing a transgene.

摘要翻译： 本发明的目的是提供一种转基因G0嵌合体鸟类所有其在转基因抗体基因用的复制缺陷型逆转录病毒载体引入，并且通过表达所述抗体的可生产; 该方法包括回收由所产生的转基因G0嵌合体鸟类表达的抗体的抗体的制造方法; 和G0转基因嵌合体鸟类，包括孵化鸟受精蛋，和后胚胎注射和独家培育的逆转录病毒载体后，立即启动了一段的生产方法。 <？>也就是说，本发明涉及一种转基因G0嵌合体鸟类所有其在转基因抗体基因用的复制缺陷型逆转录病毒载体引入，并且通过表达抗体的主要生产。

公开(公告)号：EP1422748A1

公开(公告)日：2004-05-26

申请号：EP02751808.3

申请日：2002-07-30

申请人： Nagoya Industrial Science Research Institute

发明人： HIRAMATSU, Kazumasa ,  MIYAKE, Hideto ,  YOSHIDA, Harumasa ,  URUSHIDO, Tatsuhiro ,  TERADA, Yusuke

IPC分类号： H01L21/205 ,  H01L21/3065

CPC分类号： C30B25/02 ,  C30B29/403 ,  C30B29/406 ,  C30B29/605 ,  H01L21/0242 ,  H01L21/02458 ,  H01L21/02502 ,  H01L21/02513 ,  H01L21/0254 ,  H01L21/0262 ,  H01L21/02639 ,  H01L21/0265 ,  H01L21/30621 ,  H01L21/3085 ,  H01L33/22 ,  H01L33/32

摘要： A group III nitride semiconductor film involving few lattice defects and having a large thickness, and a process for making the film are disclosed. Dry-etching is conducted while a quartz substrate and a group III nitride semiconductor are placed on the top of a lower electrode. Nano-pillars (50) are formed on the top of the group III nitride semiconductor (101). Another group III nitride semiconductor film (51) is deposited on the nano-pillars (50).

摘要翻译： 涉及几乎没有晶格缺陷并且具有大厚度的III族氮化物半导体膜，以及制造该膜的方法。 在将石英衬底和III族氮化物半导体放置在下部电极的顶部上的同时进行干蚀刻。 纳米柱（50）形成在III族氮化物半导体（101）的顶部。 另外的III族氮化物半导体膜（51）沉积在纳米柱（50）上。

公开(公告)号：EP2842553A1

公开(公告)日：2015-03-04

申请号：EP13782289.6

申请日：2013-04-26

申请人： Nippon Zoki Pharmaceutical Co., Ltd. ,  Nagoya Industrial Science Research Institute

发明人： IINUMA, Munekazu ,  FURUKAWA, Shoei ,  NAIKI, Mitsuru ,  MATSUMOTO, Tomonori ,  SAWADA, Kazuyoshi

IPC分类号： A61K31/16 ,  A61K9/08 ,  A61K9/20 ,  A61K9/70 ,  A61K31/231 ,  A61K31/265 ,  A61K47/40 ,  A61P19/02 ,  A61P29/00

CPC分类号： A61K31/40 ,  A61K9/0019 ,  A61K9/0053 ,  A61K31/16 ,  A61K31/165 ,  A61K31/231 ,  A61K31/265 ,  A61K47/40 ,  A61K47/48969 ,  A61K47/6951

摘要： An object of the present invention is to provide an analgesic effective in a prophylactic or a therapy for various pain diseases. The present invention is to provide an analgesic containing at least one member selected from a trans-2-decenoic acid derivative represented by the formula (1) and a pharmaceutically acceptable salt thereof as an active ingredient:

(In the formula, Y is -O-, -NR- or -S-, R is hydrogen atom, alkyl group, dialkylaminoalkyl group or the like and W is a substituent such as dialkylaminoalkyl group). The analgesic of the present invention containing the compound as an active ingredient is highly useful as a prophylactic or therapeutic agent for various pain diseases such as the pain caused by osteoarthritis (e.g., knee osteoarthritis and hip osteoarthritis).

摘要翻译： 本发明的目的是提供对各种疼痛疾病的预防或治疗有效的止痛剂。 本发明提供含有选自式（1）所示的反式-2-癸烯酸衍生物及其药学上可接受的盐中的至少一种作为有效成分的止痛剂：（式中，Y为-O - ， - NR-或-S-，R为氢原子，烷基，二烷基氨基烷基等，W为取代基如二烷基氨基烷基）。 含有该化合物作为有效成分的本发明的止痛剂作为骨关节炎引起的疼痛等各种疼痛疾病（例如膝骨关节炎，髋骨关节炎）的预防或治疗剂非常有用。