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61.发明公开
公开(公告)号：EP1333024A4
公开(公告)日：2005-11-16
申请号：EP01980959
申请日：2001-11-02
发明人： YAMAMOTO KENJI , SUDA YOSHIMITSU , ASAO TETSUJI
IPC分类号： A61K38/00 , A61P1/02 , A61P43/00 , C07C271/22 , C07D295/185 , C07K5/072 , C07K5/093 , A61K31/27 , A61K31/495 , A61K38/06 , C07D295/18 , C07K5/06
CPC分类号： C07D295/185 , A61K38/00 , C07C271/22 , C07K5/06104 , C07K5/0819 , Y02P20/55
摘要： Peptide derivatives represented by the general formula (I) and pharmaceutically acceptable salts thereof, processes for preparing the derivatives or the salts, and use of both: (I) wherein X is CHOH- or CO-; R?1 and R2¿ are each hydrogen or substituted oxycarbonyl; R3 is substituted oxycarbonyl; R4 is hydroxyl, lower alkoxy, optionally substituted piperazinyl, or the like; R5 is a side chain (R) of an optionally protected a-amino acid; R6 is hydroxyl, lower alkoxy, or the like; m is 0 or 1; and n is an integer of 2 to 6.
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公开(公告)号：EP0822260B1
公开(公告)日：2004-01-21
申请号：EP97904590.3
申请日：1997-02-20
发明人： KITANO, Shizuo , SASAKI, Toru , YOSHIDA, Kenichiro , OTANI, Toshio , YU, Lei , WU, Yun , KATSUNUMA, Nobuhiko
CPC分类号： C07K5/06095 , A61K38/00 , C12P21/02
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公开(公告)号：EP1012139B1
公开(公告)日：2002-11-13
申请号：EP98941015.4
申请日：1998-08-28
发明人： SETTI, Eduardo, L. , MAITI, Samarendra, N. , PHILLIPS, Oludotun, A., Dept. of Pharmaceutical , REDDY, Andhe, V., Narender , MICETICH, Ronald, G. , HIGASHITANI, Fusahiro , KUNUGITA, Chieko , NISHIDA, Koichi , UJI, Tatsuya
IPC分类号： C07D205/085 , A61K31/545 , A61K31/43
CPC分类号： C07D409/12
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64.发明授权2-OXO-1-AZETIDINE SULFONIC ACID DERIVATIVES AS POTENT BETA-LACTAMASE INHIBITORS 失效2-氧代-1-氮杂环丁烷磺酸衍生物作为β-内酰胺酶抑制剂的研究
公开(公告)号：EP0979229B1
公开(公告)日：2002-10-23
申请号：EP98915027.1
申请日：1998-04-23
发明人： MAITI, Samarendra, N. , SETTI, Eduardo, L. , PHILLIPS, Oludotun, A. , REDDY, Andhe, V., Narender , MICETICH, Ronald, G. , SINGH, Rajeshwar , HIGASHITANI, Fusahiro , KUNUGITA, Chieko , NISHIDA, Koichi , UJI, Tatsuya
IPC分类号： C07D409/14 , A61K31/44 , C07D417/14 , C07D401/14 , C07D413/14
CPC分类号： C07D409/14 , A61K31/44 , A61K31/54 , C07D413/14 , C07D417/14 , A61K2300/00
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公开(公告)号：EP0767170B1
公开(公告)日：2002-10-23
申请号：EP96909366.5
申请日：1996-04-12
发明人： KONNO, Yasuo , NOZAKI, Kenji , YAMADA, Shozo , ASAO, Tetsuji , SUZUKI, Takashi , KIMURA, Masayasu
IPC分类号： C07D239/42 , C07D401/04 , C07D403/12 , C07D417/04 , C07F9/12 , A61K31/505 , A61K31/66
CPC分类号： C07D239/42 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/04 , C07D403/12 , C07D417/04 , C07F9/65122
摘要： Novel 4,6-diarylpyrimidine derivatives represented by general formula (1), salts thereof, a process for producing the same, and a drug comprising the same as the active ingredient, wherein R represents a heterocycle or amino optionally substituted by one to four lower alkyl groups; and Ar represents phenyl, naphthyl or an aromatic heterocycle optionally having one to four substituents. The compounds have an excellent effect of inhibiting neovascularization and are useful as a remedy for solid tumor, rheumatism, diabetic retinopathy and psoriasis.
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66.发明公开
公开(公告)号：EP0974589A4
公开(公告)日：2001-07-25
申请号：EP98951721
申请日：1998-11-06
发明人： YAMADA SHOZO , HOSOYA TOSHIYUKI , KITAGAWA KAZUHIRO , INOUE SHIN-ICHI , KINIWA MAMORU , ASAO TETSUJI
IPC分类号： A61P37/00 , C07D403/04 , C07D521/00 , A61K31/415
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D403/04 , Y02P20/55
摘要： Compounds represented by general formula (I) and having both an IL-4 production inhibitory activity and a PDE(IV) inhibitory activity; a medicinal composition comprising an effective amount of any of the compounds and a pharmaceutical carrier; a remedy or preventive for acute and chronic inflammatory diseases; and an antiallergic agent or antiphlogistic agent: wherein A is a triazole group; R1 and R2 are the same or different and each is an alicyclic hydrocarbon group or an aliphatic or alicyclic hydrocarbon group optionally having an aromatic hydrocarbon group; R3 is hydrogen or a substituent; and R4 is hydrogen or a group protecting the nitrogen atom. Also provided are methods of using the compounds represented by formula (I) for the production of the medicinal composition, the remedy or preventive for acute and chronic inflammatory diseases, and the antiallergic agent or antiphlogistic agent; and a method for the therapy and/or prevention of acute and chronic inflammatory diseases.
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公开(公告)号：EP0769299A4
公开(公告)日：2000-08-09
申请号：EP96910218
申请日：1996-04-22
IPC分类号： A61K9/00 , A61K31/167 , A61K31/185 , A61K45/00 , A61K9/06 , A61K9/08
CPC分类号： A61K31/185 , A61K9/0043 , A61K31/167 , Y10S514/912
摘要： An anti-allergic pharmaceutical composition for nasal topical administration comprising an IgE antibody production inhibitor as an active ingredient, which is effective and safe in its nasal topical administration.
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68.发明公开DOUBLE-STRANDED OLIGONUCLEOTIDE AND CARCINOSTATIC AGENT CONTAINING THE SAME AS ACTIVE INGREDIENT 失效双链寡核苷酸和抗癌剂这是作为活性成分包含
公开(公告)号：EP0733640A4
公开(公告)日：1999-11-24
申请号：EP95938023
申请日：1995-11-16
IPC分类号： A61K38/00 , C12N15/113 , C07H21/04 , A61K31/70
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/13
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公开(公告)号：EP0811635A4
公开(公告)日：1999-06-09
申请号：EP96941879
申请日：1996-12-16
发明人： YAMAZAKI YASUNDO , KITAZATO KENJI
IPC分类号： A61K31/737 , C08B37/00
CPC分类号： C08B37/00 , A61K31/737 , Y10S514/824
摘要： An excellent intravascular membrane thickening inhibitor which contains as the active ingredient sulfated polysaccharides originating in sea cucumber and is useful particularly in the inhibition of the reconstriction of the coronary artery following PTCA without causing any hemorrhage symptom.
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公开(公告)号：EP0679659B1
公开(公告)日：1999-04-14
申请号：EP94931695.4
申请日：1994-11-08
发明人： KATSUNUMA, Nobuhiko , TURK, Vito
CPC分类号： C07K14/8139 , A61K38/00
摘要： A polypeptide having the amino acid sequence represented by the following SEQ ID NO: 1, and a cathepsin-L-specific inhibitor and an osteoporosis remedy each containing the polypeptide as the active ingredient. The polypeptide has such potent cathepsin-L-specific inhibitor and bone resorption inhibitor activities that it is useful for treating osteoporoses, in particular, senile osteoporosis.
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