FLUORESCENCE INTENSITY MULTIPLE DISTRIBUTIONS ANALYSIS: CONCURRENT DETERMINATION OF DIFFUSION TIMES AND MOLECULAR BRIGHTNESS
    62.
    发明公开
    FLUORESCENCE INTENSITY MULTIPLE DISTRIBUTIONS ANALYSIS: CONCURRENT DETERMINATION OF DIFFUSION TIMES AND MOLECULAR BRIGHTNESS 有权
    荧光强度分析中的应用分布的品种:扩散时间与分子亮度竞争测定

    公开(公告)号:EP1254353A1

    公开(公告)日:2002-11-06

    申请号:EP01903729.0

    申请日:2001-02-09

    Applicant: Evotec OAI AG

    Inventor: KASK, Peet

    Abstract: The present invention relates to a method for characterizing samples having fluorescent particles, comprising the steps of: (a) monitoring intensity fluctuations of fluorescence emitted by the particles in at least one measurement volume by detecting sequences of photon counts by at least one photon detector, (b) determining from the sequences of photon counts intermediate statistical data comprising at least two probability functions, P1(n1),P2(n2),..., of the number of photon counts, n1, n2,..., detected in different sets of counting time intervals, (c) determining from said intermediate statistical data a distribution of particles as a function of at least two arguments, wherein one argument is a specific brightness of the particles, or a measure thereof, and another argument is a diffusion coefficient of the particles, or a measure thereof.

    VORRICHTUNG UND VERFAHREN ZUR OPTISCHEN SPEKTROSKOPIE
    63.
    发明公开
    VORRICHTUNG UND VERFAHREN ZUR OPTISCHEN SPEKTROSKOPIE 有权
    DEVICE AND METHOD FOR光学光谱

    公开(公告)号:EP1169626A1

    公开(公告)日:2002-01-09

    申请号:EP00918863.2

    申请日:2000-04-07

    Inventor: WEITZEL, Thilo

    CPC classification number: G01J9/02 G01J3/453 G01J3/457 G01J2003/2866

    Abstract: The invention relates to a device for optical spectroscopy with means for generating an interference pattern and with a spatially resolving detector that can receive the generated interference pattern. According to the invention, the wave fronts of at least one component beam being involved in the interference pattern are influenced by spectrally dispersive or diffractive optical elements according to the wavelength.

    Verfahren und Vorrichtung zur Wirkstoffsuche
    64.
    发明公开
    Verfahren und Vorrichtung zur Wirkstoffsuche 有权
    药物发现方法和设备

    公开(公告)号:EP1033568A3

    公开(公告)日:2001-10-10

    申请号:EP00103366.1

    申请日:2000-02-22

    Abstract: Die Erfindung betrifft ein Verfahren zur Bestimmung des Übergangs mindestens eines Referenzwirkstoffs innerhalb eines Meßvolumens einer Probe von an einem in der Probe befindlichen Substrat gebundenen Zustand in einen frei diffundierenden Zustand oder umgekehrt durch Registrierung des Translationsdiffusionsverhaltens des mindestens einen Referenzwirkstoffs mittels der Ramankorrelationsspektroskopie. Ferner betrifft die Erfindung die Verwendung einer Vorrichtung zur Bestimmung des Übergangs mindestens eines Referenzwirkstoffs innerhalb eines Meßvolumens einer Probe von an einem in der Probe befindlichen Substrat gebundenen Zustand in einen frei diffundierenden Zustand oder umgekehrt, wobei die Vorrichtung mindestens die folgenden Elemente aufweist: a. eine Lichtquelle mit variabler Belichtungswellenlänge; b. eine Fokussierungseinrichtung zum Einstellen eines definierten zu untersuchenden Meßvolumens innerhalb einer Probe; c. mindestens eine Einrichtung zur Detektion von durch den Referenzwirkstoff erzeugtem Raman-Streulicht mit guter Zeitauflösung; d. eine Einrichtung zur Durchführung einer Fluktuationsanalyse zur Wirkstoffsuche.

    Messgerät zur Bestimmung der statischen und/oder dynamischen Lichtstreuung
    66.
    发明公开
    Messgerät zur Bestimmung der statischen und/oder dynamischen Lichtstreuung 失效
    测量仪器用于确定静态和/或动态光散射

    公开(公告)号:EP0867711A2

    公开(公告)日:1998-09-30

    申请号:EP98104556.0

    申请日:1998-03-13

    CPC classification number: G01J3/4412 G01J3/457 G01J2003/2866

    Abstract: Meßgerät zur Bestimmung der statischen und/oder dynamischen Lichtstreuung, das eine Lichtquelle zur Erzeugung eines Laserstrahles aufweist, mit dem eine in einer zylindrischen Küvette enthaltende Probe beleuchtet werden kann, die im Zentrum eines Drehtisches koaxial zu dessen Rotationsachse und orthogonal zum Laserstrahl angeordnet ist, wobei auf dem Drehtisch eine Vielzahl von Detektoren zur Messung des von der Probe gestreuten Lichtes in beliebigen Winkeln nebeneinander angeordnet sind.

    Abstract translation: 用于确定所述静态和/或动态光散射,其包括:光源,用于产生激光束,通过该含在圆柱形反应杯,所述样品可以被照亮,这是在同轴布置的垂直于激光束,以它的旋转轴的旋转工作台的中心的测量装置,并且其中 用于从样品中的散射光的测定的多个检测器被布置成随机的角度彼此相邻在转盘上。

    High resolution differential spectrometry system
    67.
    发明公开
    High resolution differential spectrometry system 失效
    Hochauflösendesspektrometrisches System mit Differenzbildung

    公开(公告)号:EP0747680A2

    公开(公告)日:1996-12-11

    申请号:EP96303440.0

    申请日:1996-05-15

    CPC classification number: G01J3/36 G01J3/457

    Abstract: A differential spectrometry system detects very narrow-band spectral features, while providing much higher optical transmittance and signal-to-noise ratios than prior optical-filter-based spectrometer systems. A plurality of light detectors (10a, 10b) detect light that falls within respective wide wavebands. The wide wavebands have overlapping and non-overlapping portions, one of which is the desired narrow waveband. The detector outputs are operated upon to produce an output signal (22) which includes substantially only the desired narrow waveband. In the preferred embodiment, the light detectors (10a, 10b) are implemented with a pair of optical detectors (30a, 30b) and respective optical interference filters (24a, 24b). The filters have substantially identical cut-off wavelengths (λ 2 ) and cut-on wavelengths that are shifted by Δλ with respect to each other (λ 1 and (λ 1 +Δλ), respectively). The detector outputs are differenced with an operational amplifier (33), so that detector signals resulting from spectral features common to both detectors (30a, 30b) are canceled. The remaining signal (36) varies according to the amount of light that falls between wavelength boundaries [λ 1 and (λ 1 +Δλ)]. A preferred method of fabricating the optical interference filters (24a, 24b) is also provided.

    Abstract translation: 差分光谱系统检测非常窄带的光谱特征,同时提供比现有的基于光学滤光器的光谱仪系统更高的光透射率和信噪比。 多个光检测器(10a,10b)检测落在各个宽波段内的光。 宽波段具有重叠和不重叠的部分,其中之一是期望的窄波段。 操作检测器输出以产生输出信号(22),其基本上仅包括期望的窄波段。 在优选实施例中,光检测器(10a,10b)由一对光学检测器(30a,30b)和相应的光学干涉滤光器(24a,24b)实现。 滤光器具有基本上相同的截止波长(λ2)和相对于彼此(λ1和(λ1+ΔTATAλ))偏移DELTAλ的截止波长。 检测器输出与运算放大器(33)不同,从而消除由两个检测器(30a,30b)共同的光谱特征产生的检测器信号。 剩余信号(36)根据波长边界Λλ1和(λ1+ΔTATA)Ü之间的光量而变化。 还提供了制造光学干涉滤光器(24a,24b)的优选方法。

    EXPLOSIVE SPARK ESTIMATION SYSTEM AND EXPLOSIVE SPARK ESTIMATION METHOD
    68.
    发明公开
    EXPLOSIVE SPARK ESTIMATION SYSTEM AND EXPLOSIVE SPARK ESTIMATION METHOD 审中-公开
    爆炸物爆炸物爆炸物爆炸物爆炸物爆炸物

    公开(公告)号:EP3144649A1

    公开(公告)日:2017-03-22

    申请号:EP16185099.5

    申请日:2016-08-22

    Abstract: According to one embodiment, an explosive spark estimation system (1) includes a measuring system (3) and a processing system (4). The measuring system (3) is adapted to measure intensity of light, included in a spark (S) occurred from an object (O) to be tested. The light is within at least one specific wavelength band. The processing system (4) is adapted to determine whether the spark (S) is explosiveness based on the intensity of the light. Further, according to one embodiment, an explosive spark estimation method includes: measuring intensity of light, included in a spark (S) occurred from an object (O) to be tested, within at least one specific wavelength band; and determining whether the spark (S) is explosive, based on the intensity of the light.

    Abstract translation: 根据一个实施例,爆炸性火花估计系统(1)包括测量系统(3)和处理系统(4)。 测量系统(3)适于测量包含在从被测物体(O)发生的火花(S)中的光的强度。 光在至少一个特定的波长带内。 处理系统(4)适于基于光的强度来确定火花(S)是否是爆炸性的。 此外,根据一个实施例,一种爆炸性火花估计方法包括:测量在至少一个特定波长带内从待测物体(O)发生的火花(S)中包含的光强度; 并且基于光的强度来确定火花(S)是否是爆炸性的。

    INTEGRATED COMPUTATIONAL ELEMENTS WITH LATERALLY-DISTRIBUTED SPECTRAL FILTERS
    69.
    发明公开
    INTEGRATED COMPUTATIONAL ELEMENTS WITH LATERALLY-DISTRIBUTED SPECTRAL FILTERS 审中-公开
    具有向后分布的光谱滤波器的集成计算元件

    公开(公告)号:EP2994740A1

    公开(公告)日:2016-03-16

    申请号:EP13889149.4

    申请日:2013-07-09

    Abstract: Technologies for providing optical analysis systems using an integrated computational element with laterally-distributed spectral filters are described. A measurement tool contains an optical element including a substrate and a plurality of spectral filters supported by the substrate and arranged at different lateral positions with respect to a path of light to be received from a sample during operation of the measurement tool. Each spectral filter is formed to transmit or reflect a different subset of wavelengths in a wavelength range. Additionally, each spectral filter has a respective area exposed to the light from the sample, such that the respective areas are related to a property of the sample. The wavelength range can include wavelengths in a range from about 0.2μm to about 25μm. Additionally, the sample can include wellbore fluids and the property of the sample is a property of the wellbore fluids.

    Abstract translation: 描述了使用具有横向分布光谱滤波器的集成计算元件来提供光学分析系统的技术。 测量工具包含光学元件,所述光学元件包括基板和多个光谱滤波器,所述多个光谱滤波器由所述基板支撑并且布置在相对于在所述测量工具的操作期间从样品接收的光的路径的不同横向位置处。 每个光谱滤波器被形成为透射或反射波长范围内的不同波长子集。 另外,每个光谱过滤器具有暴露于来自样品的光的相应区域,使得各个区域与样品的性质相关。 波长范围可以包括从约0.2μm至约25μm范围内的波长。 另外,样品可以包括井筒流体,并且样品的性质是井筒流体的性质。

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