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    PROCESS FOR PRODUCING HYDROPHOBIC GLYCYRRHIZA EXTRACT WITH HIGH QUALITIES
    61.
    发明公开
    PROCESS FOR PRODUCING HYDROPHOBIC GLYCYRRHIZA EXTRACT WITH HIGH QUALITIES 审中-公开
    VERFAHREN ZUR HERSTELLUNG EINES HYDROPHOBEN GLYCYRRHIZA-EXTRAKTS MIT HOHERQUALITÄT

    公开(公告)号：EP1477177A1

    公开(公告)日：2004-11-17

    申请号：EP03742669.9

    申请日：2003-02-20

    Applicant: KANEKA CORPORATION

    Inventor： YAMASHITA, Koki ,  ONO, Naoki,Sanseiso ,  KITAMURA, Shiro ,  UEDA, Yasuyoshi

    IPC: A61K35/78 ,  A61K9/20 ,  A61K9/48 ,  A61K31/352 ,  A61K31/37 ,  A61K31/56 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P9/10 ,  A61P9/12 ,  A61P43/00 ,  C07D311/18 ,  C07D311/58 ,  C07J63/00

    CPC classification number: C07J63/00 ,  A23K10/30 ,  A23K20/10 ,  A23L27/30 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/352 ,  A61K31/37 ,  A61K31/56 ,  A61K36/484 ,  A23V2250/252

    Abstract: It is an object of the present invention to provide a method for producing a hydrophobic licorice extract which is useful for applications, such as food, food additives, functional nutritive food, food for specified health uses, dietary supplements, drink, feedstuff, drugs, and quasi-drugs, and which has satisfactory powder characteristics.
    This invention relates to a method for producing a hydrophobic licorice extract comprises performing extraction from licorice with a water-soluble organic solvent, the area of the bark of the licorice occupying at least 30% of the total surface area of the licorice. This invention also relates to a method for producing a hydrophobic licorice extract comprises crystallizing an extract extracted from licorice, or an extraction residue of the licorice, with a water-soluble organic solvent in a mixed solvent comprising water and the water-soluble organic solvent, the weight ratio, water/(water-soluble organic solvent + water), being 1/3 or more.

    Abstract translation: 本发明的目的是提供一种制备疏水性甘草提取物的方法，其可用于食品，食品添加剂，功能性营养食品，特定健康用途食品，膳食补充剂，饮料，饲料，药物， 和准药，具有令人满意的粉末特性。 本发明涉及疏水性甘草提取物的制造方法，其包括用水溶性有机溶剂从甘草中提取甘草的皮肤面积占甘草总表面积的至少30％ 。 本发明还涉及一种疏水性甘草提取物的制造方法，其特征在于，将包含水和水溶性有机溶剂的混合溶剂中的从甘草提取的提取物或甘草的提取残渣与水溶性有机溶剂结晶， 重量比，水/（水溶性有机溶剂+水）为1/3以上。

    BIOACTIVE TRITERPENOIDS AND SECO-TRITERPENOIDS
    65.
    发明授权
    BIOACTIVE TRITERPENOIDS AND SECO-TRITERPENOIDS 失效
    生物活性三萜类化合物SEC0，三萜类化合物

    公开(公告)号：EP0651760B1

    公开(公告)日：2001-04-18

    申请号：EP93922096.8

    申请日：1993-10-07

    Applicant: INSTITUTO NACIONAL DE ENGENHARIA E TECNOLOGIA INDUSTRIAL

    Inventor： MOITEIRO, Cristina, Maria, Martins ,  ROSA, Maria Regina Tavares ,  MARCELO CURTO, Maria, JoAo

    IPC: C07J63/00 ,  C07H15/256 ,  A61K31/56

    CPC classification number: C07C62/06 ,  C07H15/256 ,  C07J63/008

    Abstract: The new triterpenoids of general formulae (I), (II), (III) and (IV) where R represents a dialkyl, trialkyl, triphenyl, diphenylalkyl, alkyldiphenyl, dialkylphenyl, haloalkyl, halophenylalkyl, allylalkyl or alkylaminoalkyl group and R represents a carboxyl group, salt or ester, and a process for their preparation which comprises reaction of friedelin with a silylating agent in the presence of a bulky strong base, with kinetic or thermodynamic control, to produce regio-specifically compounds of general formula (I) or (II). Oxidation of (I) or (II) yields the corresponding hydroxy ketones (VII) or (VIII), from which acyl and glycosyl derivatives can be prepared, and further oxidation of the hydroxy ketones (VII) or (VIII) with peracid gives the seco-aldehyde acids (III) or (IV), from which esters or salts can be prepared. Ozonolysis of (I) or (II), followed by reductive treatment, produces the diols of formula (IX) or (X), from which acyl and glycosyl derivatives can be prepared. Oxidation of (I) with a benzoquinone leads to friedel-1-en-2-one (XI) in high yields. Compounds or combinations of compounds (I), (II), (III), (IV), (VI), (VII), (VIII), (IX), (X), (XII), including the acyl and glycosyl derivatives thereof, find application in fungicidal, bactericidal, antitumour and antifeedant compositions.

    TRITERPENE DERIVATIVES AND REMEDY FOR LIVER DISEASES
    66.
    发明公开
    TRITERPENE DERIVATIVES AND REMEDY FOR LIVER DISEASES 失效
    三萜衍生物毒品以及针对肝病

    公开(公告)号：EP0879824A4

    公开(公告)日：2000-11-22

    申请号：EP96922260

    申请日：1996-07-08

    Applicant: MEIJI SEIKA KAISHA

    Inventor： SASAKI KAZUE ,  MINOWA NOBUTO ,  NISHIYAMA SHOJI ,  KUZUHARA HIROYUKI

    IPC: A61K31/56 ,  C07J63/00 ,  C07J71/00 ,  C07H15/256

    CPC classification number: C07J63/008 ,  C07J71/0005

    Abstract: A pharmaceutical composition for treating a hepatic disorder, comprising a triterpene derivative represented by the formula (I) or a pharmaceutically acceptable salt thereof is disclosed: wherein R represents a hydroxyl group, alkoxy, alkylcarbonyloxy, or aralkyloxy; R represents alkyl, - CH2OR , wherein R represents a hydrogen atom, alkyl, aralkyl, or alkylcarbonyl, formyl, -COOR , wherein R represents a hydrogen atom or alkyl, or -CH2N(R )R ; or R and R combine with each other to form -O-CR )-OCH2-, wherein R and R , which may be the same or different, represent a hydrogen atom, alkyl, or aryl; R and R , which may be the same or different, represent a hydrogen atom, a hydroxyl group, alkyl, hydroxyalkyl, formyl, -COOR , wherein R represents a hydrogen atom or alkyl, or -OR , wherein R represents alkyl, aralkyl, C1-6 alkylcarbonyl, arylcarbonyl, alkenyl, alkenylcarbonyl, or arylalkenylcarbonyl which may be optionally substituted; or R and R combine with each other to form a methylene group; and @ represents a single or double bond, provided that, when @ represents a double bond, R is absent.

    9 Alpha-Hydroxy-8 Alpha-estra-1,3,5(10)-triene und Verfahren zu deren Herstellung
    68.
    发明公开
    9 Alpha-Hydroxy-8 Alpha-estra-1,3,5(10)-triene und Verfahren zu deren Herstellung 失效
    9α-羟基-8α-雌-1,3,5（10） - 三烯和Verfahren zu deren Herstellung

    公开(公告)号：EP0882735A1

    公开(公告)日：1998-12-09

    申请号：EP98108657.2

    申请日：1998-05-13

    Applicant: Jenapharm GmbH & Co. KG

    Inventor： Kosemund, Dirk, Dr. ,  Schwarz, Sigfrid, Prof. Dr.

    IPC: C07J1/00 ,  C07J15/00 ,  C07J63/00 ,  C07J53/00

    CPC classification number: C07J53/004 ,  C07J1/0059 ,  C07J1/0062 ,  C07J1/007 ,  C07J1/0077 ,  C07J15/00

    Abstract: Die Erfindung beinhaltet 9α-Hydroxy-8α-estra-1,3,5(10)-triene als neue Steroidzwischenprodukte, die geeignet sind zur Synthese von Steroidverbindungen aus Estra-1,3,5(10),9(11)-tetraenen.
    Es wird weiterhin ein Verfahren zur Herstellung der erfindungsgemäßen 9α-Hydroxy-8α-estra-1,3,5(10)-triene beschrieben, wobei Estra-1,3,5(10),8-tetraene hydroboriert und die gebildeten Organoborane anschließend oxydiert werden.
    Die erfindungsgemäßen Steroidzwischenprodukte realisieren die Verkürzung der Totalsynthese therapeutisch relevanter 11-substituierter Steroidverbindungen, ausgehend von Estra-1,3,5(10),8-tetraen-Derivaten.

    Abstract translation: 式（I）的9α-羟基-8α-去甲-1,3,5（10） - 三烯衍生物是新的。 R1 = H或1-4C烷基; R2 = Me或Et; R3，R4 = H或任选保护的羟基; 或R 3 + R 4 = O（氧代）; R5 =α-或β-H，R6 = H; 或R5 + R6 =α，α-CH2或β，β-CH2（完成稠合的环丙烷环）。

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