摘要:
The present invention relates to novel 4-substituted-quinoline compounds of formula (I), libraries containing such compounds, and to the generation of such combinatorial libraries composed of such compounds, wherein R?1, R2, R3, R4, R5, R6, R7, R9¿, and Y, have the meanings provided.
摘要:
The present invention provides anthraquinonyl and anthronyl dyes and dichroic light polarizers based on the dyes. The dichroic light polarizer includes two separate embodiments. In the first embodiment, the dye molecules are aggregated into particles oriented in a predetermined direction on the surface of a substrate to enable the dye to polarize light transmitted through the dye. In the other embodiment, the dye molecules are molecularly oriented in a non-periodic arrangement of different polarizing elements on the surface of a substrate. Each of the polarizing elements has a differing orientation of the polarization vector in the substrate plane and/or a different color. The dichroic light polarizer may contain one or more additional dye layers and may have a transparent layer intermediate between the dye layers.
摘要:
This invention relates to a key intermediate in the synthesis of an endothelin antagonist, the synthesis of this key intermediate and the synthesis of an endothelin antagonist using this intermediate in a stereoselective deoxygenation reaction.
摘要:
Compounds of formula: and stereoisomers thereof, wherein W is an unsubstituted pyridyl or unsubstituted pyrimidinyl group linked to A by any one of its ring carbon atoms; A is either an oxygen atom or S(O) n , wherein n is 0, 1 or 2; X; Y and Z, which are the same or different, are hydrogen or halogen atoms, or hydroxy, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted alkoxy, optionally substituted aryl, optionally substituted aryloxy, optionally substituted aralkyl, optionally substituted arylalkoxy, optionally substituted acyloxy, optionally substituted amino, optionally substituted acylamino, nitro, cyano, - C0 2 R 3 , -CONR 4 R 5 , -COR 6 or-S(O) n R 7 (wherein n is 0, 1 or 2) groups, or any two of the groups X, Y and Z, when they are in adjacent positions on the phenyl ring, join to form a fused ring, either aromatic or aliphatic, optionally containing one or more heteroatoms, provided that when A is oxygen, X is hydrogen, and R 1 and R 2 are both methyl, Y and Z are not both hydrogen, Y is not F, CI, methyl, nitro, 5-CF 3 , 5-SCH 3 or 4-(CH 3 ) 2 N if Z is hydrogen and Y and Z together are not 3-nitro-5-chloro, 3,5-dinitro, 4,5-dimethoxy or 4,5-methylenedioxy; R 1 and R 2 , which are the same or different, are optionally substituted alkyl groups; and R 3 , R 4 , R 5 , R6 and R 7 which are the same or different, are hydrogen atoms or optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, or optionally substituted aralkyl groups; and metal complexes thereof. The compounds are useful as fungicides.
摘要:
The present invention is directed to compositions comprising an extrudate or solid solution of a compound, or a salt thereof, of Formula I (API): Formula I, wherein "R a " is independently H or -F, in a water-soluble polymer matrix which further comprises a disintegration system allowing a tablet made therefrom to rapidly disintegrate in the environment in which the API is to be released.