公开(公告)号：EP2660238A1

公开(公告)日：2013-11-06

申请号：EP13175561.3

申请日：2010-01-08

申请人： RESVERLOGIX CORP.

发明人： Hansen, C., Henrik

IPC分类号： C07D239/91 ,  C07D403/04 ,  C07D403/02 ,  A61K31/517 ,  A61K31/519 ,  A61P9/00

CPC分类号： C07D239/91 ,  A61K31/517 ,  C07D401/04 ,  C07D403/04 ,  C07D471/04

摘要： Disclosed are novel compounds that are useful for regulating the expression of apolipoprotein A-I (ApoA-I), and their use for the treatment and prevention of cardiovascular disease and related disease states, including cholesterol- or lipid-related disorders, such as, for example, atherosclerosis. Also disclosed are pharmaceutical compositions comprising the novel compounds.

摘要翻译： 公开了可用于调节载脂蛋白AI（ApoA-I）表达的新型化合物及其用于治疗和预防心血管疾病和相关疾病状态的用途，包括胆固醇或脂质相关疾病，例如 ，动脉粥样硬化。 还公开了包含新化合物的药物组合物。

公开(公告)号：EP1737831B1

公开(公告)日：2013-05-22

申请号：EP05714346.3

申请日：2005-04-01

申请人： Prana Biotechnology Limited

发明人： KOK, Gaik, Beng ,  LEUNG, Brenda, Kwan, Yi

IPC分类号： C07D239/88 ,  C07D239/90 ,  C07D239/91 ,  A61K31/517 ,  A61P25/28 ,  C07D239/92

CPC分类号： C07D471/04 ,  C07C51/367 ,  C07C227/04 ,  C07C229/64 ,  C07D239/90 ,  C07D239/91 ,  C07D239/92 ,  C07D401/04 ,  C07D401/06 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/10 ,  C07D403/12 ,  C07D413/06 ,  C07D417/04 ,  C07D417/06 ,  C07D417/10 ,  C07D417/14 ,  C07C65/03

公开(公告)号：EP2344475A4

公开(公告)日：2012-05-30

申请号：EP09817056

申请日：2009-09-29

申请人： SIRTRIS PHARMACEUTICALS INC

发明人： VU CHI B ,  OALMANN CHRISTOPHER ,  PERNI ROBERT B ,  WHITE BRIAN

IPC分类号： C07D401/12 ,  A61K31/4375 ,  A61K31/439 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/506 ,  A61K31/517 ,  A61K31/5377 ,  A61P3/10 ,  A61P5/50 ,  C07D239/91 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D453/02

CPC分类号： A61K31/5377 ,  A61K31/353 ,  A61K31/4025 ,  A61K31/4155 ,  A61K31/422 ,  A61K31/427 ,  A61K31/4433 ,  A61K31/4439 ,  A61K31/497 ,  A61K31/506 ,  A61K45/06 ,  C07D311/30 ,  C07D405/12 ,  C07D405/14 ,  C07D417/12 ,  C07D417/14 ,  A61K2300/00

摘要： Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

公开(公告)号：EP2266962A4

公开(公告)日：2011-12-07

申请号：EP09719079

申请日：2009-03-05

申请人： GUANGZHOU INST BIOMED & HEALTH

发明人： DING KE ,  WONG CHIWAI ,  KANG ZHANFANG ,  ZHOU XI

IPC分类号： C07D239/88 ,  A61K31/517 ,  A61K31/519 ,  A61P3/00 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P9/00 ,  A61P9/10 ,  C07D239/86 ,  C07D239/90 ,  C07D239/91 ,  C07D471/04 ,  C07D487/04

CPC分类号： C07D239/86 ,  C07D239/90 ,  C07D239/91 ,  C07D471/04 ,  C07D487/04

公开(公告)号：EP2350030A1

公开(公告)日：2011-08-03

申请号：EP09749198.9

申请日：2009-09-08

申请人： Council Of Scientific & Industrial Research

发明人： KAMAL, Ahmed ,  BHARATHI, Earla, Vijaya ,  REDDY, Jonnala, Surendranadha ,  DASTAGIRI, Dudekula ,  VISWANATH, Arutla

IPC分类号： C07D239/91 ,  C07D413/12 ,  A61K31/422 ,  A61K31/517 ,  A61P35/00

CPC分类号： C07D239/91 ,  C07D413/12

摘要： The present invention provides a compound of general formulae 3a-i to 6a-i, 7a-i to 10a- i, 12a-i to 15a-i, 16a-i to 19a-i, 21a-i to 24a-i, 25a-i to 28a-i, 30a-i to 33a-i, 34a-i to37a-i and 39a-i to 42a-i, 43a-i to 46a-i useful as potential antitumour agents against human cancer cell lines and a process for the preparation thereof.

公开(公告)号：EP2118074A4

公开(公告)日：2011-06-15

申请号：EP07710597

申请日：2007-02-01

申请人： RESVERLOGIX CORP

发明人： HANSEN HENRIK

IPC分类号： C07D239/91 ,  A61K31/4375 ,  A61K31/472 ,  A61K31/496 ,  A61K31/517 ,  A61K31/519 ,  A61K31/5377 ,  A61P3/06 ,  A61P9/00 ,  C07D217/24 ,  C07D401/04 ,  C07D401/12 ,  C07D403/10 ,  C07D405/04 ,  C07D413/06 ,  C07D471/04

CPC分类号： A61K31/517 ,  A61K31/4375 ,  A61K31/44 ,  A61K31/47 ,  A61K31/472 ,  A61K31/496 ,  A61K31/497 ,  A61K31/519 ,  A61K31/535 ,  A61K31/5377 ,  A61K31/54 ,  A61K31/695 ,  A61L29/16 ,  A61L31/16 ,  A61L2300/204 ,  A61L2300/606 ,  A61L2420/00 ,  C07D217/24 ,  C07D239/91 ,  C07D279/02 ,  C07D401/04 ,  C07D403/12 ,  C07D405/04 ,  C07D471/04 ,  C07F7/1804

摘要： The present disclosure relates to compounds, which are useful for regulating the expression of apolipoprotein A-I (ApoA-I), and their use for treatment and prevention of cardiovascular disease and related disease states, including cholesterol- or lipid-related disorders, such as, for example, atherosclerosis.

公开(公告)号：EP1682520B1

公开(公告)日：2011-02-23

申请号：EP04768990.6

申请日：2004-10-22

申请人： AstraZeneca AB

发明人： BROWN, Dearg Sutherland ,  NASH, Ian Alun

IPC分类号： C07D239/91 ,  A61K31/513

CPC分类号： C04B35/632 ,  C07D239/91 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  C07D487/08

摘要： The invention concerns a compound of the Formula (I) wherein m is 0-2 and each R1 is a group such as hydroxy, halogeno, trifluoromethyl heterocyclyl and heterocyclyloxy; R2 is halogeno, trifluoromethyl or (1-6C)alkyl; R3 is hydrogen, halogeno or (1-6C)alkyl; and R4 is (3-6C)cycloalkyl;or pharmaceutically-acceptable salts thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or medical condions mediated by cytokines.

公开(公告)号：EP2097391A1

公开(公告)日：2009-09-09

申请号：EP07822642.0

申请日：2007-11-15

申请人： High Point Pharmaceuticals, LLC

发明人： OLESEN, Preben Houlberg ,  PETERSEN, Anders Klarskov ,  NIELSEN, Flemming Elmelund ,  CHRISTIANSEN, Lise Brown ,  HANSEN, Holger Claus

IPC分类号： C07D239/91 ,  A61K31/517 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P9/12

CPC分类号： C07D239/91

摘要： The present invention relates to novel compounds that act as chemical uncouplers. Compounds of the invention are useful, inter alia, in the treatment, including prevention, of obesity, diabetes and a number of diseases or conditions associated therewith.

公开(公告)号：EP1569916B1

公开(公告)日：2009-01-07

申请号：EP03808341.6

申请日：2003-11-14

申请人： CADILA HEALTHCARE LIMITED

发明人： LOHRAY, Braj, Bhushan, Cadila Healthcare Limited ,  LOHRAY, Vidya, Bhushan, Cadila Healthcare Limited ,  JAIN, Mukul, R., Cadila Healthcare Limited ,  BASU, Sujay, Cadila Healthcare Limited ,  PINGALI, Harikishore, Cadila Healthcare Limited ,  RAVAL, Saurin, K., Cadila Healthcare Limited ,  RAVAL, Preeti, S., Cadila Healthcare Limited

IPC分类号： C07D239/91 ,  C07D279/16 ,  C07D413/04 ,  C07D265/38 ,  C07D209/86 ,  C07D215/14 ,  C07D209/08 ,  C07D213/30 ,  C07D207/32 ,  C07D235/06 ,  C07D409/04 ,  C07D261/08 ,  C07D405/04 ,  A61K31/421 ,  A61K31/422

CPC分类号： C07D207/325 ,  C07C43/23 ,  C07D209/08 ,  C07D209/86 ,  C07D213/30 ,  C07D215/14 ,  C07D235/06 ,  C07D239/91 ,  C07D261/08 ,  C07D265/38 ,  C07D279/16 ,  C07D405/04 ,  C07D409/04 ,  C07D413/04

摘要： The present invention relates to novel substituted aralkyl derivatives of the general formula (I) & (IIIa), their derivatives, their analogs, their tautomeric forms, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates, pharmaceutical compositions containing them, use of these compounds in medicine and the intermediates involved in their preparation.

公开(公告)号：EP1699767A4

公开(公告)日：2008-12-03

申请号：EP04816043

申请日：2004-12-31

申请人： SCIOS INC

发明人： CHAKRAVARTY SARVAJIT ,  DUGAR SUNDEEP ,  TESTER RICHLAND ,  CONTE AURELIA

IPC分类号： C07D239/90 ,  C07D239/91 ,  C07D471/04 ,  C07D487/02

CPC分类号： C07D239/91 ,  C07D471/04

摘要： The present invention is directed to a rpocess for making 2-substituted pyridopyrimidones. In particular, 2-substituted pyridopyrimidones are made through the single step reaction of suitable acid derivatives with desired derivatives of amidines.

摘要翻译： 本发明涉及制备2-取代的吡啶并嘧啶酮的方法。 具体地说，2-取代的吡啶并嘧啶酮是通过合适的酸衍生物与期望的脒衍生物的单步反应制备的。