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242 条记录 (耗时 0.015 秒)

    ANOMERIC DERIVATIVES OF MONOSACCHARIDES
    64.
    发明公开
    ANOMERIC DERIVATIVES OF MONOSACCHARIDES 审中-公开
    单糖异头

    公开(公告)号：EP1487812A1

    公开(公告)日：2004-12-22

    申请号：EP03745223.2

    申请日：2003-03-28

    申请人： Alchemia Limited

    发明人： MEUTERMANS, Wim ,  WEST, Michael, Leo ,  THANH LE, Giang ,  ADAMSON, George ,  SCHAFER, Karl ,  ABBENANTE, Giovani

    IPC分类号： C07D307/20 ,  C07D307/22 ,  C07D307/24 ,  C07D309/08 ,  C07D309/10 ,  C07D309/14 ,  C07H5/04 ,  C07H7/02 ,  C07H7/04

    CPC分类号： C07D405/12 ,  C07D309/14 ,  C07F7/1856 ,  C07H15/12

    摘要： A compound of formula (I), wherein, n is 0 or 1; R6 and R7 are h ydrogen, or together form a carbonyl oxygen; R1 is selected from the group consisting of hydrogen; -N(Z)Y and -C(Z)Y wherein; When R1 is -N(Z)Y, then: Y is selected from hydrogen, or the following, where G denotes the point of connection to the nitrogen atom in N(Y)Z (i-v); Z is selected from hydrogen or X1; Q is selected from hydrogen or W; The groups W are independently selected from the group consisting of alkyl, alkenyl, alkynyl, heteroalkyl, aryl, heteroaryl, arylalkyl and heteroarylalkyl of 1 to 20 atoms , The groups X1 are independently selected from the group consisting of alkyl, alkenyl, alkynyl, heteroalkyl, acyl, arylacyl, heteroarylacyl, aryl, heteroaryl, arylalkyl and heteroarylalkyl of 1 to 20 atoms , When R1 is -C(Z)Y, then: Y is selected from the group consisting of two hydrogen atoms, a double bonded oxygen (=O) to form a carbonyl, and a triple bonded nitrogen to form a nitrile, Z is absent, or is selected from hydrogen or U, Wherein U is selected from the group consisting of alkyl, alkenyl, alkynyl, heteroalkyl, aminoalkyl, aminoaryl, aryloxy, alkoxy, heteroaryloxy, aminoaryl, aminoheteroaryl, thioalkyl, thioaryl or thioheteroaryl, acyl, arylacyl, heteroarylacyl, aryl, heteroaryl, arylalkyl and heteroarylalkyl of 1 to 20 atoms, . When R1 is H, at least two of the groups R2, R3, R4 and R5 are selected from the group consisting of -OX2 or -N(T)Y, and the others are independently selected from hydrogen, -OH, -OX2, -N(T)Y, wherein Y is as defined above, T is selected from hydrogen or X2; and X2 is independently selected from alkyl, alkenyl, alkynyl, heteroalkyl, aryl, heteroaryl, arylalkyl or heteroarylalkyl of 1 to 20 atoms, When R1 is N(Z)Y or C(Z)Y, at least one of the groups R2, R3, R4 and R5 are selected from the group consisting of -OX2 or -N(T)Y, and the others are independently selected from hydrogen, -OH, -OX2, -N(T)Y, wherein Y is as defined above, T is selected from hydrogen or X2; and X2 is independently selected from alkyl, alkenyl, alkynyl, heteroalkyl, aryl, heteroaryl, arylalkyl or heteroarylalkyl of 1 to 20 atoms.

    METHOD FOR PURIFICATION OF ACARBOSE
    65.
    发明公开
    METHOD FOR PURIFICATION OF ACARBOSE 审中-公开
    程序对清洁ACARBOSE

    公开(公告)号：EP1309601A1

    公开(公告)日：2003-05-14

    申请号：EP01963821.2

    申请日：2001-08-07

    申请人： BIOGAL GYOGYSZERGYAR RT.

    发明人： KERI, Vilmos ,  DEAK, Lajos ,  SZABO, Csaba

    IPC分类号： C07H1/06 ,  C07H5/04 ,  C07H15/22 ,  C07H15/232

    CPC分类号： C07H17/08 ,  C07H1/08

    摘要： The present invention relates to a novel process for the preparation of acarbose. Said process comprises the steps of: 1) acidifying a fermentation broth containing an acarbose; 2) removing particulates from the fermentation broth; 3) adsorbing the acarbose on a cation-exchanger in the presence of an anion of a weak acid; 4) eluting the acarbose from the cation-exchanger with at least one of hydrochloric acid and the weak acid; 5) precipitating the acarbose with a solvent; and 6) separating the acarbose.

    Process for the preparation of organic azides
    68.
    发明公开
    Process for the preparation of organic azides 有权
    一种用于生产的有机叠氮化物处理

    公开(公告)号：EP1029867A3

    公开(公告)日：2001-03-14

    申请号：EP00200466.1

    申请日：2000-02-14

    申请人： Akzo Nobel N.V. ,  SANOFI-SYNTHELABO

    发明人： Claassen, Henricus Cornelis Jozephus

    IPC分类号： C07H15/04 ,  C07H5/04

    CPC分类号： C07H5/04

    摘要： A process for the addition of an azide function to an organic compound in which process a mixture is prepared by adding an epoxide-derivative of the organic compound and an alkali metal azide salt to a solvent is described. The mixture is heated to a reaction temperature at which the epoxide-derivative and the azide can react to form an azide derivative of the organic compound. An amount, near equimolar to the epoxide derivative, of a (1-6C)alkyl-(2-4C)carboxylic acid ester having a boiling point above the reaction temperature is added to the mixture before and/or during the reaction.

    POLYSACCHARIDES HAVING A HIGH IDURONIC ACID CONTENT
    70.
    发明授权
    POLYSACCHARIDES HAVING A HIGH IDURONIC ACID CONTENT 失效
    随着艾杜高百分比多糖

    公开(公告)号：EP0789777B1

    公开(公告)日：2000-08-09

    申请号：EP95937026.3

    申请日：1995-10-30

    申请人： INALCO S.p.A.

    发明人： ZOPPETTI, Giorgio ,  ORESTE, Pasqua ,  CIPOLLETTI, Giovanni

    IPC分类号： C12P19/26 ,  C07H5/04 ,  A61K31/715

    CPC分类号： C12P19/26 ,  C08B37/0075

    摘要： Process for the preparation of polysaccharides having a high iduronic acid content comprising: a) N-deacetylation of the polysaccharide K5 from E. coli or of the heparan sulfate or O-desulfation of heparin or heparan sulfate; b) N-sulfation of the product obtained from the stage a); c) epimerization in presence of the C5 epimerase enzyme; d) sulfation of at least some free hydroxy groups, wherein the stage c) is carried out in a reaction medium constituted by a classical buffer solution formed by HEPES, potassium chloride, EDTA and TRITON X-100 to which a suitable additive is added.