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71.发明公开
公开(公告)号：EP2386856A2
公开(公告)日：2011-11-16
申请号：EP11154010.0
申请日：2005-06-21
申请人： Galapagos N.V.
发明人： Vandeghinste, Nick , Tomme, Peter Herwig Maria , Michiels, Frits , Ma, Libin , Mille-Baker, Blandine , van Es, Helmuth H.G.
IPC分类号： G01N33/50
CPC分类号： C07H21/04 , A61K38/1709 , A61K48/00 , C12N15/111 , C12N2310/14 , C12N2320/12 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/5008 , G01N33/6887 , G01N33/6893 , G01N2800/105 , Y10T436/143333
摘要： The present invention relates to in vivo and in vitro methods, agents and compound screening assays for inducing anabolic stimulation of chondrocytes, including cartilage formation enhancing pharmaceutical compositions, and the use thereof in treating and/or preventing a disease involving a systemic or local decrease in mean cartilage thickness in a subject.
摘要翻译： 本发明涉及体内和体外方法，用于诱导软骨细胞的合成代谢刺激的化合物筛选试验，包括软骨形成增强药物组合物，及其用于治疗和/或预防涉及全身或局部减少的疾病 平均软骨厚度在受试者。
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72.发明公开METHOD FOR IDENTIFYING COMPOUNDS USEFUL FOR INCREASING THE FUNCTIONAL ACTIVITY AND CELL SURFACE EXPRESSION OF CF-ASSOCIATED MUTANT CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR 有权方法化合物用于增加CF ASSOZIERTEM突变囊性纤维化跨膜传导调节剂的活性鉴定（CFTR）
公开(公告)号：EP2352828A1
公开(公告)日：2011-08-10
申请号：EP09782853.7
申请日：2009-09-10
申请人： Galapagos N.V.
发明人： FISCHER, David Frederik , JANSSEN, Richard Antonius Jozef , ROSEBOOM, Marjet , SCAFFIDI, Amelia Katie , TESSARI, Michela
CPC分类号： G01N33/5041 , C12N15/111 , C12N15/1138 , C12N2310/14 , C12N2310/531 , C12N2320/12 , C12N2330/31 , C12N2330/51 , C12Q1/6883 , G01N33/6872 , G01N33/6893 , G01N2500/00 , G01N2800/382
摘要： The present invention relates to agents, and methods for identifying compounds, which agents and compounds result in the modulation of cellular trafficking of proteins in particular that of CF- associated mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR). In addition, the invention relates to compositions and methods for the use thereof in treating conditions that are characterized by an ER-associated protein misfolding and abnormal cellular trafficking of disease-associated proteins, including cystic fibrosis (CF).
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73.发明公开Methods, compositions and compound assays for inhibiting amyloid-beta protein production 审中-公开方法，组合物和测试化合物抑制β-淀粉样蛋白生产
公开(公告)号：EP2267458A3
公开(公告)日：2011-04-06
申请号：EP10174532.1
申请日：2005-04-20
申请人： Galapagos N.V.
IPC分类号： G01N33/68 , G01N33/566
CPC分类号： C12Q1/37 , G01N33/566 , G01N33/6896 , G01N2333/4709 , G01N2333/726 , G01N2500/00 , G01N2800/2821
摘要： A method for identifying compounds that inhibit amyloid-beta precursor protein processing in cells, comprising contacting a test compound with a GPCR polypeptide (GPR12), or fragment thereof, and measuring a compound-GPCR property related to the production of amyloid-beta peptide. Cellular assays of the method measure indicators including second messenger and/or amyloid beta peptide levels. Therapeutic methods, and pharmaceutical compositions including effective amyloid-beta precursor processing-inhibiting amounts of GPCR expression inhibitors, are useful for treating conditions involving cognitive impairment such as Alzheimers Disease.
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74.发明授权TRIAZOLOPYRIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES 有权三唑并吡啶化合物用于治疗退化性和炎性疾病
公开(公告)号：EP2086540B8
公开(公告)日：2011-03-02
申请号：EP07857236.9
申请日：2007-11-30
申请人： Galapagos N.V.
发明人： BURRITT, Andrew , EDWARDS, Paul John , SCHMIDT, Wolfgang , BIRAULT, Veronique , KROLL, Friedrich Erich Karl , TAO, Xueliang , ANDREWS, Martin James Inglis , MARTINA, Sébastien Laurent Xavier
IPC分类号： A61K31/437 , C07D471/04 , A61P29/00
CPC分类号： C07D471/04
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75.发明公开Methods for identification, and compounds useful for the treatment of degenerative and inflammatory diseases 审中-公开的退行性疾病和炎性疾病的治疗方法和化合物的识别
公开(公告)号：EP2256198A1
公开(公告)日：2010-12-01
申请号：EP10174544.6
申请日：2005-06-14
申请人： Galapagos N.V.
IPC分类号： C12N15/11
CPC分类号： C12Q1/37 , C12N9/6491 , C12N15/111 , C12N2310/14 , C12N2320/12 , G01N33/6887 , G01N2333/96486 , G01N2500/04 , G01N2800/102
摘要： The present invention relates to in vivo and in vitro methods, agents and compound screening assays for inhibiting extra-cellular matrix degradation, including joint degenerative inhibiting and/or anti-inflammatory pharmaceutical compositions, and the use thereof in treating and/or preventing a disease involving extra-cellular matrix degradation in a subject.
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76.发明公开IMIDAZOLOPYRIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES 审中-公开炎症性疾病及适宜IMIDAZOLOPYRIDINVERBINDUNGEN退行性的治疗
公开(公告)号：EP2099798A1
公开(公告)日：2009-09-16
申请号：EP07847622.3
申请日：2007-11-30
申请人： Galapagos N.V.
发明人： EDWARDS, Paul John , MARTINA, Sébastien Laurent Xavier , ANDREWS, Martin James Inglis , BAR, Grégory Louis Joseph , ALLART, Brigitte , BURRITT, Andrew , TAO, Xueliang , KROLL, Friedrich Erich Karl
IPC分类号： C07D471/04 , A61K31/437 , A61P29/00 , A61P19/02
CPC分类号： C07D471/04
摘要： Novel imidazolopyridine compounds are disclosed that have a formula represented by Formula (I). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, ECM degradation, joint degradation and/or inflammation, and others.
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77.发明公开METHODS, COMPOSITIONS AND COMPOUND ASSAYS FOR INHIBITING AMYLOID-BETA PROTEIN PRODUCTION 有权方法，组成和复合测定为了抑制淀粉样-β蛋白生产
公开(公告)号：EP1745295A2
公开(公告)日：2007-01-24
申请号：EP05744241.0
申请日：2005-04-20
申请人： Galapagos N.V.
IPC分类号： G01N33/68 , G01N33/566
CPC分类号： C12Q1/37 , G01N33/566 , G01N33/6896 , G01N2333/4709 , G01N2333/726 , G01N2500/00 , G01N2800/2821
摘要： A method for identifying compounds that inhibit amyloid-beta precursor protein processing in cells, comprising contacting a test compound with a GPCR polypeptide, (eg. GPR3, GPR6, GPR12) or fragment thereof, and measuring a compound-GPCR property related to the production of amyloid-beta peptide. Cellular assays of the method measure indicators including second messenger and/or amyloid beta peptide levels. Therapeutic methods, and pharmaceutical compositions including effective amyloid-beta precursor processing-inhibiting amounts of GPCR expression inhibitors, are useful for treating conditions involving cognitive impairment such as Alzheimers Disease.
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78.发明授权
公开(公告)号：EP3947378B1
公开(公告)日：2024-11-13
申请号：EP20715295.0
申请日：2020-03-24
发明人： MAMMOLITI, Oscar , JARY, Hélène, Marie , ORSULIC, Mislav , VRBAN, Denana , KOMAC, Marijana , BRYS, Reginald, Christophe, Xavier , AKKARI, Rhalid
IPC分类号： C07D471/04 , A61P31/18 , A61K31/662
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79.发明授权
公开(公告)号：EP3958863B1
公开(公告)日：2024-07-03
申请号：EP20721493.3
申请日：2020-04-21
IPC分类号： A61K31/4545 , A61K31/155 , A61K31/55 , A61P13/12 , A61K45/06
CPC分类号： A61P13/12 , A61K31/55 , A61K31/155 , A61K45/06 , A61K31/4545
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公开(公告)号：EP3378862B1
公开(公告)日：2022-03-16
申请号：EP17184834.4
申请日：2012-12-20
发明人： LABÉGUÈRE, Frédéric Gilbert , NEWSOME, Gregory John Robert , ALVEY, Luke Jonathan , SANIÈRE, Laurent Raymond Maurice , FLETCHER, Stephen Robert
IPC分类号： C07D471/04 , A61K31/529 , A61P9/10
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