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    MONITORING OF INTRACELLULAR MITOCHONDRIAL LOCALIZATION
    71.
    发明公开
    MONITORING OF INTRACELLULAR MITOCHONDRIAL LOCALIZATION 审中-公开
    ÜBERWACHUNGINTRAZELLULÄRERMITOCHONDRIALER LOKALISIERUNG

    公开(公告)号：EP1961824A1

    公开(公告)日：2008-08-27

    申请号：EP06834714.5

    申请日：2006-12-14

    申请人： Kyushu University, National University Corporation

    发明人： ONA, Toshihiro, c/o Kyushu University ,  KOSAIHIRA, Atsushi, c/o Kyushu University

    IPC分类号： C12Q1/02 ,  G01N21/27 ,  G01N21/64 ,  G01N33/15 ,  G01N33/50 ,  G01N33/543

    CPC分类号： G01N33/5035 ,  G01N21/553 ,  G01N21/64

    摘要： An object is a method of detecting changes in mitochondrial polarized state in a living cell.
    Changes in surface plasmon resonance angle resulting from changes in mitochondrial polarized state of the living cells are detected by use of a surface plasmon resonance device. Alternatively, one or plural agents are administered to the living cells, and changes in surface plasmon resonance angle resulting from changes in mitochondrial polarized state are detected. The step of detecting changes in surface plasmon resonance angle resulting from changes in mitochondrial polarized state can be realized by the step of detecting changes in surface plasmon resonance angle during a period in which the changes only result from changes in mitochondrial polarized state, and it is preferable that the changes be detected during a period that comes after a lapse of 20 minutes or longer after the agent(s) was administered, preferably after a lapse of 30 minutes or longer, more preferably after a lapse of 35 minutes or longer.

    摘要翻译： 目的是检测活细胞线粒体极化状态的变化。 通过使用表面等离子体共振装置检测由活细胞的线粒体极化状态的变化引起的表面等离子体共振角的变化。 或者，将一种或多种药剂施用于活细胞，并检测由线粒体极化状态的变化引起的表面等离子体共振角的变化。 检测由线粒体极化状态变化引起的表面等离子体共振角变化的步骤可以通过在线粒体极化状态发生变化的时期内检测表面等离子体共振角的变化的步骤来实现， 优选在给药剂20分钟以上，优选经过30分钟以上，更优选经过35分钟以上之后的期间内检测到变化。

    SUBSTRATE FOR ANALYSIS FOR USE IN RAMAN SPECTROSCOPIC ANALYSIS AND SUBSTRATE ASSEMBLY FOR ANALYSIS
    72.
    发明公开
    SUBSTRATE FOR ANALYSIS FOR USE IN RAMAN SPECTROSCOPIC ANALYSIS AND SUBSTRATE ASSEMBLY FOR ANALYSIS 审中-公开
    ANALYSESUBSTRAT ZUR VERWENDUNG BEI DER RAMAN-SPEKTROSKOPIE-ANALYZE SOWIE ANALYSESUBSTRATKONSTRUKTION

    公开(公告)号：EP1950556A1

    公开(公告)日：2008-07-30

    申请号：EP06821905.4

    申请日：2006-10-18

    申请人： Kyushu University, National University Corporation

    发明人： ONA, Toshihiro ,  MURAKAMI, Shuichi

    IPC分类号： G01N21/65

    CPC分类号： G01N21/658

    摘要： To provide a substrate and a substrate assembly for Raman spectroscopic analysis that are capable of analyzing even a substance of a low concentration with high sensitivity.
    A substrate 1 for Raman spectroscopic analysis comprises a predetermined transparent substrate 3 and metal particles 5 unevenly applied to a surface of the transparent substrate 3.

    摘要翻译： 提供能够分析甚至具有高灵敏度的低浓度物质的用于拉曼光谱分析的衬底和衬底组件。 用于拉曼光谱分析的基板1包括预定的透明基板3和不均匀地施加到透明基板3的表面的金属颗粒5。

    PROCESS FOR PRODUCTION OF POLYMER USING IRON COMPLEX AS CATALYST
    73.
    发明公开
    PROCESS FOR PRODUCTION OF POLYMER USING IRON COMPLEX AS CATALYST 有权
    VERFAHREN ZUR HERSTELLUNG EINES POLYMERS UNTER VERWENDUNG EINES EISENKOMPLEXES ALS KATALYSATOR

    公开(公告)号：EP1944325A1

    公开(公告)日：2008-07-16

    申请号：EP06797875.9

    申请日：2006-09-12

    申请人： Kyushu University, National University Corporation ,  DIC Corporation

    发明人： NAGASHIMA, Hideo ,  NIIBAYASHI, Shota ,  JIN, Ren-Hua, c/o Dainippon Ink and Chemicals, Inc. ,  HAYAKAWA, Hitoshi, c/o Dainippon Ink and Chemicals, Inc.

    IPC分类号： C08F4/40

    CPC分类号： C08F4/40 ,  C08F6/02 ,  C08F20/18 ,  C08F293/005 ,  C08F2438/01

    摘要： The object of the present invention is to provide a method of producing a polymer wherein radical-polymerizable monomers can be polymerized in a quantitative manner in a relatively short time, and a polymer or a block copolymer having at its termini a functional group that can be chemically converted while the polymer or the block copolymer has a high molecular weight can be produced. Furthermore, the object of the present invention is to provide a method of producing a polymer wherein the polymer is re-precipitated in a general solvent by an easy method, and the used iron complexes are recovered in the solvent, thereby recycling the iron complexes.

    摘要翻译： 本发明的目的是提供一种生产聚合物的方法，其中可自由基聚合的单体可以在相当短的时间内以定量方式聚合，并且聚合物或嵌段共聚物在其末端具有官能团，其可以是 可以在聚合物或嵌段共聚物具有高分子量的情况下进行化学转化。 此外，本发明的目的是提供一种聚合物的制造方法，其中通过简单的方法将聚合物在一般溶剂中再沉淀，并将所用的铁络合物回收到溶剂中，从而再循环铁络合物。

    SENSOR PART AND BIOLOGICAL SENSOR
    75.
    发明公开
    SENSOR PART AND BIOLOGICAL SENSOR 有权
    传感器生物学家传感器

    公开(公告)号：EP1810613A1

    公开(公告)日：2007-07-25

    申请号：EP05805475.0

    申请日：2005-11-01

    申请人： Kyushu University, National University Corporation ,  The University of Tokyo

    发明人： SAWADA, Renshi, Kyushu University ,  HIGURASHI, Eiji, The University of Tokyo

    IPC分类号： A61B5/026 ,  A61B5/0245 ,  G01N21/49 ,  H01L31/12

    CPC分类号： A61B5/0261 ,  G01N21/49

    摘要： A highly miniaturized biosensor and a sensor unit, which can meet a demand for further miniaturization. With this invention, miniaturization is possible, and the number of production steps including those for assembling individual parts can be reduced. Accordingly, mass production will be possible, and cost reduction and high reliability will be achieved. A light emitting unit (21) and a light receiving unit (22) are disposed in a same recess (24) formed on a surface of a semiconductor substrate (23), and a light shielding cover substrate (27) having a first light guide section (25) and a second light guide section (26) is disposed on an upper side of the semiconductor substrate (23). Since the light receiving unit (22) is formed with arrayed light receiving elements (28), the same number of the second light guide sections (26) as the light receiving elements (28) are provided on the light shielding cover substrate (27), and the light receiving surfaces of the light receiving elements (28) are connected to one end of each of the second light guiding sections (26) so as to conform to each other without any gap.

    摘要翻译： 高度小型化的生物传感器和传感器单元，可满足进一步小型化的需求。 利用本发明，可以实现小型化，并且可以减少包括用于组装各个部件的生产步骤的数量。 因此，可以进行批量生产，并且将实现成本降低和高可靠性。 发光单元（21）和光接收单元（22）设置在形成在半导体衬底（23）的表面上的同一凹部（24）中，并且具有第一导光体 部分（25）和第二导光部分（26）设置在半导体衬底（23）的上侧。 由于光接收单元（22）形成有排列的光接收元件（28），所以在遮光盖基板（27）上设置与光接收元件（28）相同数量的第二导光部（26） ，并且光接收元件（28）的光接收表面连接到每个第二导光部分（26）的一端，以便彼此一致而没有任何间隙。