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    INCREASING CONFIDENCE OF ALLELE CALLS WITH MOLECULAR COUNTING
    71.
    发明公开
    INCREASING CONFIDENCE OF ALLELE CALLS WITH MOLECULAR COUNTING 无效
    ERHÖHUNGDERVERLÄSSLICHKEITVON ALLEL-AUFRUFEN MITMOLEKÜLZÄHLUNG

    公开(公告)号：EP2619327A2

    公开(公告)日：2013-07-31

    申请号：EP11810645.9

    申请日：2011-09-20

    申请人： Population Genetics Technologies LTD.

    发明人： CASBON, James ,  BRENNER, Sydney ,  OSBORNE, Robert ,  LICHTENSTEIN, Conrad ,  CLAAS, Andreas

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6855 ,  C12N15/1065 ,  C12Q1/6869 ,  C12Q1/6886 ,  C12Q1/70 ,  G06F19/18 ,  C12Q2525/179 ,  C12Q2525/191 ,  C12Q2545/101

    摘要： Aspects of the present invention include methods and compositions for determining the number of individual polynucleotide molecules originating from the same genomic region of the same original sample that have been sequenced in a particular sequence analysis configuration or process. In these aspects of the invention, a degenerate base region (DBR) is attached to the starting polynucleotide molecules that are subsequently sequenced (e.g., after certain process steps are performed, e.g., amplification and/or enrichment). The number of different DBR sequences present in a sequencing run can be used to determine/estimate the number of different starting polynucleotides that have been sequenced. DBRs can be used to enhance numerous different nucleic acid sequence analysis applications, including allowing higher confidence allele call determinations in genotyping applications.

    摘要翻译： 本发明的方面包括用于确定源自在特定序列分析配置或过程中测序的相同原始样品的相同基因组区域的单个多核苷酸分子数目的方法和组合物。 在本发明的这些方面，将简并碱基区（DBR）连接到随后测序的起始多核苷酸分子（例如，在进行某些工艺步骤之后，例如扩增和/或富集）。 存在于测序运行中的不同DBR序列的数目可用于确定/估计已测序的不同起始多核苷酸的数目。 DBR可用于增强许多不同的核酸序列分析应用，包括在基因分型应用中允许更高置信等位基因调用测定。

    Balloon-expandable/self-expanding prosthesis
    72.
    发明公开
    Balloon-expandable/self-expanding prosthesis 有权
    球囊扩张/自扩张假体

    公开(公告)号：EP2614795A2

    公开(公告)日：2013-07-17

    申请号：EP12275210.8

    申请日：2012-12-18

    申请人： Cook Medical Technologies LLC

    发明人： Vad, Siddharth

    IPC分类号： A61F2/86

    CPC分类号： A61F2/94 ,  A61F2/86 ,  A61F2/89 ,  A61F2/958 ,  A61F2002/821 ,  A61F2002/825 ,  A61F2220/0075 ,  A61F2250/0018 ,  A61F2250/0048 ,  C22F1/10

    摘要： A hybrid prosthesis (100) for deployment in a body vessel includes a tubular stent body (110) comprising a wire (105) comprising a shape memory alloy, where the tubular stent body (110) has a self-expanding portion (110a) comprising a distal portion (115) of the wire (105) and a balloon-expandable portion (110b) comprising a proximal portion (120) of the wire (105). The shape memory alloy comprises an A f of less than 37°C in the self-expanding portion (110a) and an A s of greater than 37°C in the balloon-expandable portion (110b).

    摘要翻译： 一种用于部署在身体血管中的混合假体（100），包括：管状支架主体（110），其包括包含形状记忆合金的丝（105），其中所述管状支架主体（110）具有自膨胀部分（110a） 所述丝（105）的远侧部分（115）和包括所述丝（105）的近侧部分（120）的球囊可扩张部分（110b）。 形状记忆合金包括在自膨胀部分（110a）中小于37℃的Af和在球囊可膨胀部分（110b）中大于37℃的As。

    ROTATIONAL CONTROLLED DEPLOYMENT DEVICE
    77.
    发明公开
    ROTATIONAL CONTROLLED DEPLOYMENT DEVICE 审中-公开
    旋转延伸扩展

    公开(公告)号：EP2490629A1

    公开(公告)日：2012-08-29

    申请号：EP10774047.4

    申请日：2010-10-14

    申请人： William A. Cook Australia Pty. Ltd. ,  Cook Medical Technologies LLC

    发明人： HARTLEY, David, Ernest ,  DUCKE, Werner, Dieter

    IPC分类号： A61F2/84

    CPC分类号： A61F2/966 ,  A61F2/95 ,  A61F2002/9517 ,  A61F2002/9665

    摘要： A stent graft deployment device assembly (10) has a cylindrical fixed handle (6) to be gripped and held by a user and an tubular release handle (30) extending through the fixed handle. The release handle can be moved through the fixed handle. The deployment device assembly has a pusher assembly and a sheath (18) to cover a stent graft on the pusher assembly. The pusher assembly is connected to the fixed handle and the sheath is connected to the release handle so that retraction of the release handle through the fixed handle causes the sheath to be retracted from the stent graft on the pusher assembly. The fixed handle has a rotator component (36) with internal first and second screw threads. The tubular release handle has an external screw thread (31) which engages with the first screw thread. The external screw thread (31) can extend along part, all or in segments along the release handle. A release clamp (48) on the pusher has pins which engage with the second screw thread. Movement of the rotator component with respect to the fixed handle first moves the tubular release handle with respect to the fixed handle and subsequently moves the release clamp on the pusher and thereby pulls the trigger wires.

    Drive assembly for facilitating deployment of an implantable medical device
    78.
    发明公开
    Drive assembly for facilitating deployment of an implantable medical device 有权
    驱动组件，以促进可植入医疗设备的插入

    公开(公告)号：EP2486896A1

    公开(公告)日：2012-08-15

    申请号：EP12154962.0

    申请日：2012-02-10

    申请人： Cook Medical Technologies LLC

    发明人： Nielsen, Arne Moelgaard

    IPC分类号： A61F2/84

    CPC分类号： A61F2/966 ,  A61F2002/9517 ,  A61F2250/0073

    摘要： A drive assembly (50, 100) for an introducer assembly (10) for the deployment of an implantable medical device (16) includes a sprung element (52) coupled to a yoke (56). The yoke (56) is coupled to a gripper element (58). The yoke (56) is coupled to a first handle unit (30) of the introducer (10). The sprung element (52) is coupled to a proximal handle unit (32). A brake element (66, 102) acts to prevent operation of the sprung element (52) when no manual force is being applied to retract a sheath (24) and the assembly (10). When manual retraction force is applied to the gripper element (58), the brake element (66, 102) releases the sprung element (52) so that the latter can apply a force assistance to assist in the retraction of the sheath (24) and thereby to assist in the deployment of a medical device.

    摘要翻译： 在引导器组件（10），用于可植入医疗装置（16）的部署的驱动组件（50，100）包括耦合到磁轭（56）的尖锐元件（52）。 磁轭（56）被耦合到一个夹持件（58）。 所述轭架（56）联接到所述导引器（10）的第一手柄部（30）。 尖锐元件（52）被耦合到近侧手柄部（32）。 的制动元件（66，102）的作用是防止当没有手动的力被施加到缩回的护套（24）和所述组件（10）的尖锐元件（52）的手术。 当手动回缩力施加到夹持元件（58），制动元件（66，102）释放跳跃元件（52）象后者可以施加力协助，以帮助在所述护套（24）的缩回和 从而，以协助医疗装置的部署。