公开(公告)号：EP3313427A2

公开(公告)日：2018-05-02

申请号：EP16815459.9

申请日：2016-06-24

申请人： Fred Hutchinson Cancer Research Center

发明人： OLSON, James ,  STRAND, Andrew, David ,  GIRARD, Emily, June ,  STRONG, Roland ,  MEHLIN, Christopher ,  CORRENTI, Colin ,  MHYRE, Andrew, James ,  BRUSNIAK, Mi-youn ,  SOTTERO, Theo

IPC分类号： A61K38/16 ,  A61K49/14 ,  A61K38/03

CPC分类号： C07K14/43522 ,  A61K38/00 ,  C07K14/43518

摘要： Peptides that home, distribute to, target, are directed to, or accumulate in tumors, cancers, or diseased cells are disclosed. Peptides that cross the blood brain barrier and home, distribute to, target, are directed to, or accumulate in the brain and in a specific region of the brain are also disclosed. Pharmaceutical compositions and uses for peptides or peptide-active agent complexes comprisingsuch peptides are additionally disclosed. Such compositions can be formulated for targeted or untargeted delivery of a drug to a target region, tissue, structure or cell. Targeted compositions of thedisclosure can deliver peptide or peptide- active agent complexes to target regions, tissues, structures or cells targeted by the peptide.

公开(公告)号：EP3165533A1

公开(公告)日：2017-05-10

申请号：EP16189999.2

申请日：2011-02-04

申请人： Fred Hutchinson Cancer Research Center

发明人： OLSON, James M.

IPC分类号： C07K14/435 ,  A61K38/17 ,  C07K19/00 ,  A61K47/42 ,  G01N33/574 ,  A61K49/00

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K47/6415 ,  C07K14/43522

摘要： Chlorotoxin variants, chlorotoxin variant conjugates, compositions that include the chlorotoxin variants or conjugates, and methods for using the chlorotoxin variants, conjugates, and compositions. In particular, conjugates comprising a chlorotoxin variant where lysine K15 and/or lysine K23 are substituted by other amino acids, coupled to a fluorescent label.

摘要翻译： 氯毒素变体，氯毒素变体缀合物，包含氯毒素变体或缀合物的组合物，以及使用氯毒素变体，缀合物和组合物的方法。 特别地，包含氯代毒素变体的缀合物，其中赖氨酸K15和/或赖氨酸K23被其他氨基酸取代，与荧光标记偶联。

公开(公告)号：EP2944957A1

公开(公告)日：2015-11-18

申请号：EP15163430.0

申请日：2004-12-15

申请人： Fred Hutchinson Cancer Research Center

发明人： Ostrander, Elaine ,  Kruglyak, Leonid ,  Parker, Heidi G. ,  Kim, Lisa V. ,  Stephens, Matthew ,  Malek, Tiffany B. ,  Sutter, Nathan B. ,  Carlson, Scott

IPC分类号： G01N33/48 ,  G01N33/50 ,  C12Q1/68 ,  G06F19/18

CPC分类号： C12Q1/6888 ,  C12Q2600/156 ,  G06F19/18

摘要： In one aspect, the invention provides methods for determining the contributions of canid populations to a canid genome. The methods comprise the steps of: (a) obtaining the identity of one or both alleles in a test canid genome for each of a set of markers; and (b) determining the contributions of canid populations to the test canid genome by comparing the alleles in the test canid genome to a database comprising canid population profiles, wherein each canid population profile comprises genotype information for the set of markers in the canid populations.

摘要翻译： 一方面，本发明提供了确定犬种群对犬科基因组的贡献的方法。 所述方法包括以下步骤：（a）在一组标记物中获得测试犬基因组中一个或两个等位基因的同一性; 并且（b）通过将测试犬基因组中的等位基因与包含犬种群概况的数据库进行比较来确定犬种群对测试犬基因组的贡献，其中每个犬种群体谱包括在犬种群中的该组标记的基因型信息。

公开(公告)号：EP2928914A1

公开(公告)日：2015-10-14

申请号：EP13814726.9

申请日：2013-12-10

申请人： Fred Hutchinson Cancer Research Center

发明人： OLSON, James ,  MEHLIN, Christopher ,  STROUD, Mark ,  SIMON, Julian ,  CORRENTI, Colin ,  PADDISON, Patrick ,  STRONG, Roland ,  MAY, Damon

IPC分类号： C07K14/435

CPC分类号： G01N33/5008 ,  A61K38/1767 ,  A61K45/06 ,  A61K49/00 ,  C07K14/43522 ,  C07K14/47 ,  C07K16/00 ,  C07K2319/00 ,  C12N9/0083 ,  C12Y114/99003 ,  G01N33/5308 ,  G01N2500/00 ,  G01N2500/10 ,  G01N2500/20

摘要： Methods and systems for discovering drug candidates are disclosed. Methods and systems can include generating libraries of potential drug candidates (e.g., libraries of peptides) that can be screened to identify sub-libraries of potential drug candidates (e.g., sub-libraries of peptides) having selected pharmacological properties. Methods of making and using peptide libraries are also provided. D-amino acid chlorotoxins and D-amino acid chlorotoxin variants are also provided.

摘要翻译： 公开了发现候选药物的方法和系统。 方法和系统可以包括产生潜在药物候选物（例如，肽文库）的文库，其可筛选以鉴定具有所选药理学性质的潜在药物候选物（例如肽的亚文库）的亚文库。 还提供了制备和使用肽文库的方法。 还提供D-氨基酸氯毒素和D-氨基酸氯毒素变体。

公开(公告)号：EP2900674A1

公开(公告)日：2015-08-05

申请号：EP13774891.9

申请日：2013-09-27

申请人： University of Washington through its Center for Commercialization ,  Fred Hutchinson Cancer Research Center

发明人： RUBEL, Edwin ,  SIMON, Julian ,  CHEN, Xinchao ,  CHOWDHURY, Sarwat ,  HERR, R., Jason ,  JIANG, Qin ,  OWENS, Kelly, N. ,  RAIBLE, David ,  JOHNSON, Graham

IPC分类号： C07D495/04 ,  A61K31/407

CPC分类号： C07D495/04 ,  A61K31/4365 ,  A61K31/439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/70 ,  A61K45/06 ,  C07D495/08 ,  C07D495/18

摘要： Disclosed herein are compounds, and pharmaceutical compositions that include such compounds, for preventing, treating, and/or protecting against sensory hair cell death. Methods of using the compounds, alone or in combination with other therapeutic agents, are also disclosed.

公开(公告)号：EP2861738A1

公开(公告)日：2015-04-22

申请号：EP13807865.4

申请日：2013-06-18

申请人： Fred Hutchinson Cancer Research Center ,  Leiden University Medical Center ,  University of Rochester Medical Center ,  University of Washington through its Center for Commercialization

发明人： TAPSCOTT, Stephen ,  MILLER, Daniel, G. ,  VAN DER MAAREL, Silvere ,  TAWIL, Rabi

IPC分类号： C12N15/12 ,  C12Q1/68

CPC分类号： C12Q1/6883 ,  C07K14/47 ,  C07K14/4707 ,  C12N15/113 ,  C12N2310/14 ,  C12N2320/30 ,  C12Q2600/112 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/6887 ,  G01N2333/4712 ,  G01N2800/10 ,  C12N2310/531

摘要： The present invention relates generally to the field of molecular biology and genetics. More particularly, it concerns methods and compositions for detecting, diagnosing, and/or treating facioscapulohumeral dystrophy (FSHD2).

摘要翻译： 本发明一般涉及分子生物学和遗传学领域。 更具体地说，涉及检测，诊断和/或治疗面肩肱型营养不良症（FSHD2）的方法和组合物。

公开(公告)号：EP2820154A1

公开(公告)日：2015-01-07

申请号：EP13710232.3

申请日：2013-03-01

申请人： Fred Hutchinson Cancer Research Center

发明人： NELSON, J., Lee ,  LAMBERT, Nathalie, C. ,  GADI, Vijayakrishna, K. ,  YAN, Zhen

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6881 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158

摘要： The present disclosure provides a panel of nucleic acid molecule primers specific for HLA-specific alleles and other genetic polymorphisms, which are useful for quantitatively amplifying these markers to detect, diagnose, and monitor individuals who have or are at risk of certain disease conditions, such as autoimmune disease, proliferative disease, infectious disease, allograft rejection, or pregnancy-related pathologies.

公开(公告)号：EP2788476A1

公开(公告)日：2014-10-15

申请号：EP12806795.6

申请日：2012-12-07

申请人： Fred Hutchinson Cancer Research Center ,  Novartis Institute For Functional Genomics, Inc. d/b/a The Genomics Institute of the Novartis Research Foundation (GNF)

发明人： BERNSTEIN, Irwin, D. ,  BOITANO, Anthony, E. ,  COOKE, Michael

IPC分类号： C12N5/0789 ,  A61K35/12

CPC分类号： C12N5/0647 ,  A61K35/28 ,  A61K2035/124 ,  C12N2501/125 ,  C12N2501/145 ,  C12N2501/2303 ,  C12N2501/2306 ,  C12N2501/26 ,  C12N2501/38 ,  C12N2501/42 ,  C12N2501/60 ,  C12N2501/999

摘要： The present invention relates to methods, kits and compositions for expansion of hematopoietic stem/progenitor cells and providing hematopoietic function to human patients in need thereof. In one aspect, it relates to kits and compositions comprising a Notch agonist and an aryl hydrocarbon receptor antagonist. Also provided herein are methods for expanding the hematopoietic stem/progenitor cells using kits and compositions comprising a Notch agonist and an aryl hydrocarbon receptor antagonist. The hematopoietic stem/progenitor cells expanded using the disclosed kits, compositions and methods include human umbilical cord blood stem/progenitor cells, placental cord blood stem/progenitor cells and peripheral blood stem cells. The present invention also relates to administering hematopoietic stem/progenitor cells expanded using a combination of a Notch agonist and an aryl hydrocarbon receptor antagonist to a patient for short-term and/or long-term in vivo repopulation benefits.

摘要翻译： 本发明涉及一种方法，试剂盒和组合物的造血干/祖细胞和造血功能提供对人类患者需要其的膨胀。 在一个方面，它涉及试剂盒和组合物，包含一陷波激动剂芳香烃受体拮抗剂和。 所以提供了用于使用试剂盒扩大的造血干/祖细胞和组合物，其包括的Notch激动剂芳香烃受体拮抗剂和方法。 使用盘扩大了的造血干/祖细胞的试剂盒游离缺失，组合物和方法包括人脐血干/祖细胞，胎盘脐带血干细胞/祖细胞和外周血干细胞。 因此，本发明涉及管理使用的Notch激动剂和芳香烃受体拮抗剂的组合，以在体内再增殖好处短期和/或长期的患者扩增的造血干/祖细胞。

公开(公告)号：EP2683398A1

公开(公告)日：2014-01-15

申请号：EP12757360.8

申请日：2012-03-09

申请人： Omni Bio Pharmaceutical, Inc. ,  Fred Hutchinson Cancer Research Center

发明人： CRAPO, James D. ,  MARCONDES, A. Mario Q. ,  DEEG, H. Joachim

IPC分类号： A61K38/55 ,  A61P35/00

CPC分类号： A61K38/57 ,  A61K9/0019 ,  A61K38/00 ,  A61K38/55 ,  C07K14/8125

摘要： Embodiments described herein relate to compositions, methods and uses for alpha-1 antitrypsin (AAT) or derivatives or analogs or peptides or mutants thereof for treating a subject exposed to radiation. In certain embodiments, AAT or derivatives thereof or analogs thereof can be used to modulate adverse effects of radiation therapy on subjects undergoing treatment for cancer. In other embodiments, compositions disclosed herein can be used for treating a subject having been exposed to non-therapeutic or accidental radiation. Some embodiments reported herein concern compositions and methods for enhancing radiotherapy. Certain embodiments relate to methods and compositions for preventing or reducing radiation exposure-induced cellular damage in a subject.

公开(公告)号：EP2363022A3

公开(公告)日：2011-12-21

申请号：EP11157706.0

申请日：2004-10-22

申请人： Fred Hutchinson Cancer Research Center

发明人： Roth, Mark, B. ,  Blackstone, Eric

IPC分类号： A01N1/02

CPC分类号： C12N5/00 ,  A01N1/02 ,  A01N1/0221 ,  C12N2500/02

摘要： There is provided the use of oxygen antagonists for inducing stasis in cells, tissues and/or organs in vivo or in an organism overall. It includes methods and apparatuses for achieving stasis in any of these biological materials, so as to preserve and/or protect them. In specific embodiments, therapeutic methods and apparatuses for organ transplantation, hyperthermia, wound healing, hemorrhagic shock, cardioplegia for bypass surgery, neurodegeneration, hypothermia and cancer is provided.