公开(公告)号：EP0989105A1

公开(公告)日：2000-03-29

申请号：EP99913604.7

申请日：1999-04-09

申请人： SUNTORY LIMITED

发明人： NAKAHARA, Koichi ,  FUJII, Takahisa ,  MIKI, Wataru ,  NAGAMI, Kenzo ,  ARAI, Kunio

IPC分类号： C07B63/00

CPC分类号： C07B61/00 ,  C07C45/78 ,  Y02P20/544

摘要： The present invention provides a process for producing aromatic compounds or polymers thereof from a plant material in a short period of time and by a simple procedure. Concretely, the process treats the plant material with supercritical water or subcritical water to liberate aromatic compounds, which are contained in the plant material, and/or aromatic compounds, which have been generated upon decomposition of components of the plant material, to the outside of the plant material, and isolates the liberated aromatic compounds to produce aromatic compounds or polymers thereof.

摘要翻译： 本发明提供了一种在短时间内由植物材料制备芳族化合物或其聚合物的方法，并且通过简单的方法。 具体地，该方法用超临界水或亚临界水处理植物材料，以释放植物材料中所含的芳族化合物和/或在植物材料成分分解时产生的芳族化合物， 植物材料，并分离释放的芳族化合物以产生芳族化合物或其聚合物。

公开(公告)号：EP0970089A2

公开(公告)日：2000-01-12

申请号：EP98961599.2

申请日：1998-12-25

申请人： SUNTORY LIMITED

发明人： MIZUNO, Akira ,  SHIBATA, Makoto ,  KAMEI, Tomoe ,  FUKAMI, Harukazu ,  INOMATA, Norio

IPC分类号： C07D513/04 ,  A61K31/54

CPC分类号： C07D513/04 ,  C07D207/36

摘要： A pyrrolesulfonamide compound having formula (I) wherein the ring P represented by (α) is a pyrrole ring having structure (β) or (γ) wherein A represents alkylene, alkenylene or alkynylene; and Y represents a group (δ) in which W represents CH, C= or N; m stands for 0 or 1 when W is CH or N, or m stands for 1 when W is C=; B represents a specific divalent group; E1 and E2 each independently represents H or lower alkyl; and D represents an aromatic hydrocarbon group or heterocyclic group; $(1,3)$ stands for 0 or 1; the dashed line indicates the presence or absence of a bond; and, when the bond is present, Z2 is not present and Z1 represents H but, when the bond is absent, Z1 represents H and Z2 represents OH or Z1 and Z2 are combined together to represent O or a group NOR5, in which R5 represents H, or alkyl, aralkyl or aryl; and R represents H, alkyl, cycloalkyl, cycloalkyl-alkyl or aralkyl. The compound (1) has been improved in potency, selectivity to receptors other than serotonin-2 receptors, toxicity, side effects and/or the like over medicines reported to date and equipped with α1-blocking action and serotonin-2 receptor antagonistic action in combination.

公开(公告)号：EP0966440A1

公开(公告)日：1999-12-29

申请号：EP98921776.0

申请日：1998-05-22

申请人： SUNTORY LIMITED

发明人： TATSUOKA, Toshio ,  KAMEI, Katsuhide

IPC分类号： C07D213 ,  C07D413

CPC分类号： C07D213/22 ,  C07D413/14

摘要： A method of production of 2,4'-dipyridyl derivatives by a cross coupling reaction of a 2-halopyridine derivative and a 4-halopyridine using a nickel complex catalyst and a method of separation of a 2,4'-dipyridyl derivative from a mixture of dipyridyl isomers containing a 2,2'-dipyridyl derivative, 2,4'-dipyridyl derivative, and 4,4'-dipyridyl by using a dilute aqueous copper sulfate solution to insolubilize and remove the 2,2'-dipyridyl derivative and 4,4'-dipyridyl is disclosed.

公开(公告)号：EP0963338A1

公开(公告)日：1999-12-15

申请号：EP98961545.0

申请日：1998-12-25

申请人： SUNTORY LIMITED ,  FUJI ELECTRIC CO., LTD.

发明人： YAMASHITA, Tomohiro, Fuji Electric Co., Ltd. ,  NISHIKAWA, Kenji, Suntory Limited ,  KUNISAKI, Shinichi, Suntory Limited

IPC分类号： F25D25 ,  B67D1 ,  B67D3 ,  F25D11

CPC分类号： B67D1/07 ,  B67D3/0009 ,  B67D3/0022 ,  B67D2210/00013

摘要： A drinking water dispenser which supplies drinking water from a detachable water container (1). The dispenser is comprised of a hot water tank (3) for heating water supplied from the water container, a chilled water tank (4) for cooling water supplied from the water container, and a supply pipe (2) for connecting the water container and the tanks. A sterilization system (9-11) sterilizes the chilled water tank and the supply pipe by circulating hot water therein.

公开(公告)号：EP0576251B1

公开(公告)日：1999-11-24

申请号：EP93304858.9

申请日：1993-06-22

申请人： SUNTORY LIMITED ,  SHIONOGI & CO., LTD.

发明人： Fukami, Harukazu ,  Hashimoto, Masaki ,  Niwata, Shinjiro ,  Imose, Jun ,  Kawaguchi, Harumoto ,  Takahashi, Toshio

IPC分类号： C07D401/12 ,  A61K31/53 ,  A01N43/707 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12

CPC分类号： C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12

公开(公告)号：EP0825263A3

公开(公告)日：1999-09-15

申请号：EP97306494.2

申请日：1997-08-26

申请人： SUNTORY LIMITED

发明人： Akimoto, Kengo ,  Kawashima, Hiroshi ,  Shimizu, Sakayu

IPC分类号： C12P7/64

CPC分类号： C12P7/6427 ,  C12P7/6472

摘要： The present invention discloses a process for producing lipid containing omega-9 highly unsaturated fatty acid by culturing in a medium a mutant strain obtained by mutation on a microorganism having the ability to produce arachidonic acid belonging to the genus Mortierella and so forth, in which Δ12 desaturation activity is decreased or lost, but at least one of Δ5 desaturation activity, Δ6 desaturation activity and chain length elongation activity is elevated. Moreover, the present invention also discloses a process for producing omega-9 highly unsaturated fatty acid by collecting omega-9 highly unsaturated fatty acid from the culture or lipid described above.

公开(公告)号：EP0825261A3

公开(公告)日：1999-08-04

申请号：EP97306248.2

申请日：1997-08-18

申请人： SUNTORY LIMITED

发明人： Hatanaka, Haruyo ,  Ashikari, Toshihiko, Ashikari ,  Ogawa, Jun ,  Shimizu, Sakayu

IPC分类号： C12N15/56 ,  C12N9/24 ,  C12N1/21 ,  C12C7/00

CPC分类号： C12Y302/02001 ,  C12C5/00 ,  C12C5/004 ,  C12C7/00 ,  C12N9/2497

摘要： Novel purine nucleosidase derived from Ochrobactrum anthropi microorganisms, a gene system coding therefor, uses therefor and particularly its use in the production of beer.

公开(公告)号：EP0745669A3

公开(公告)日：1999-05-26

申请号：EP96303939.1

申请日：1996-05-31

申请人： SUNTORY LIMITED

发明人： Yabuta, Masayuki ,  Ohsuye, Kazuhiro

IPC分类号： C12N9/00

CPC分类号： C07K14/58 ,  C07K2319/00 ,  C12N9/52

摘要： Mutant proteases are obtained with one or more mutation sites in the natural V8 protease protein, and with enzyme activities even in the presence of high urea concentrations. Inactivation of enzyme activity is minimized even in the presence of high concentrations of urea, to thus allow lower amounts of enzyme to be added to urea-containing reaction systems and shorten reaction times. As an additional advantage, the ability to cleave proteins in the presence of high urea concentrations makes it possible to obtain hitherto unobtainable peptide fragments.

公开(公告)号：EP0911034A1

公开(公告)日：1999-04-28

申请号：EP98901522.7

申请日：1998-02-05

申请人： SUNTORY LIMITED

发明人： INOMATA, Norio, Suntory Inst.for Biomedical Res. ,  YAMAKI, Akira, Suntory Inst. for Biomedical Res. ,  FURUYA, Mayumi, Suntory Inst. for Biomedical Res. ,  HIDAKA, Toshinori, Suntory Inst. for Biomedical

IPC分类号： A61K38/22 ,  A61K45/00

CPC分类号： A61K38/2242

摘要： The present invention provides a pharmaceutical composition for treatment of heart disease based on cardiac hypertrophy, a cause of the onset of heart diseases such as ischemic heart disease and arrhythmia. Consequently, the present invention provides a pharmaceutical composition for treatment of heart disease based on cardiac hypertrophy having for its active ingredient a substance that binds to the NP receptor, GC-A, and is able to accelerate the production of cGMP. Specific examples of active ingredients include natriuretic peptides such as atrial natriuretic peptide and brain natriuretic peptide.

摘要翻译： 本发明提供了一种用于治疗心脏肥大的心脏病的药物组合物，心脏病发作的原因，例如缺血性心脏病和心律失常。 因此，本发明提供了一种用于治疗基于心脏肥大的心脏病的药物组合物，其具有其活性成分与NP受体结合的物质GC-A，并且能够加速cGMP的产生。 活性成分的具体实例包括利钠肽，例如心房钠尿肽和脑利钠肽。

公开(公告)号：EP0796609A3

公开(公告)日：1999-03-03

申请号：EP97104606.5

申请日：1997-03-18

申请人： SUNTORY LIMITED

发明人： Matsui, Yokichi ,  Takahata, Kyoya

IPC分类号： A61K7/06

CPC分类号： A61Q7/00 ,  A23F3/163 ,  A23F3/32 ,  A61K8/97

摘要： The present invention provides an antialopecia agent which is a drug for protecting, reducting or preventing alopecia frequently occurring as the side effect of anticancer agents, inflicts neither any pain nor unpleasantness on patients under the treatment with anticancer agents and has a high safety; and foods or beverages containing this antialopecia agent. The antialopecia agent of the present invention is characterized by containing oolong tea extract as the active ingredient.

摘要翻译： 本发明提供作为抗癌剂的副作用而经常发生的脱发的药物的抗真菌药，对抗癌剂治疗的患者既没有任何疼痛也不令人不快，安全性高; 以及含有该抗真菌药物的食品或饮料。 本发明的抗真菌药物的特征在于含有乌龙茶提取物作为活性成分。