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公开(公告)号:EP0749496A4
公开(公告)日:1999-03-03
申请号:EP95909338
申请日:1995-01-25
发明人: HASELTINE WILLIAM A , RUBEN STEVEN M , WEI YING-FEI , ADAMS MARK D , FLEISCHMANN ROBERT D , FRASER CLAIRE M , FULDNER REBECCA A , KIRKNESS EWEN F , ROSEN CRAIG A
IPC分类号: C12N15/09 , A61K31/7088 , A61K38/00 , A61K48/00 , A61P35/00 , C07K14/435 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02 , C12P21/08 , C12Q1/68 , C12R1/19 , A61K51/00 , C07K1/00 , C12N9/08
CPC分类号: C07K14/47 , Y10T436/143333
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公开(公告)号:EP0832125A4
公开(公告)日:1998-12-30
申请号:EP95922960
申请日:1995-06-05
发明人: SOPPET DANIEL R , LI YI , ROSEN CRAIG A , RUBEN STEVEN M
IPC分类号: C12N15/09 , A61K38/00 , A61K45/00 , A61K48/00 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , C07K14/705 , C07K14/715 , C07K16/28 , C12N5/10 , C12N15/12 , C12P21/02 , G01N33/566
CPC分类号: C07K14/7158 , A61K38/00 , A61K48/00 , C07K14/705 , C12N2799/026
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公开(公告)号:EP1633316A4
公开(公告)日:2008-04-02
申请号:EP04775943
申请日:2004-05-05
IPC分类号: C07K16/28 , A61K20060101 , A61K39/395 , A61P25/28 , A61P35/00 , A61P37/00 , C07K16/30 , C12N5/24
CPC分类号: C07K16/2878 , A61K2039/505 , C07K16/30 , C07K2317/56 , C07K2317/622 , C07K2317/73 , C07K2317/92 , C07K2319/30
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公开(公告)号:EP1325021A4
公开(公告)日:2005-05-04
申请号:EP01910338
申请日:2001-01-17
发明人: ROSEN CRAIG A , KOMATSOULIS GEORGE A , BAKER KEVIN P , BIRSE CHARLES E , SOPPET DANIEL R , OLSEN HENRIK S , MOORE PAUL A , WEI PING , EBNER REINHARD , DUAN D ROXANNE , SHI YANGGU , CHOI GIL H , FISCELLA MICHELE , NI JIAN
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75.HUMAN TUMOR NECROSIS FACTOR RECEPTORS TR21 AND TR22 审中-公开
标题翻译: MENSCHLICHE TUMOR NEKROSIS FAKTOR REZEPTOREN TR21 UND TR22(04.02.02)公开(公告)号:EP1313503A4
公开(公告)日:2005-05-04
申请号:EP01959117
申请日:2001-07-23
发明人: ZENG ZHIZHEN , RUBEN STEVEN M , ROSEN CRAIG A
IPC分类号: A61K38/00 , A61K38/17 , A61P29/00 , C07K14/47 , C07K14/715 , C07K16/28 , A61K39/00 , A61K39/395 , C07K1/00 , C07K16/00 , C12N5/06 , C12N5/10 , C12N5/16 , G01N33/574
CPC分类号: C07K14/7151 , A61K38/00 , A61K2039/505 , C07K16/2878 , C07K2317/622 , C07K2319/30 , G01N2333/70578
摘要: The present invention relates to two novel proteins, TR21 and TR22, which are members of the tumor necrosis factor (TNF) receptor. In particular, isolated nucleic acid molecules are provided encoding the human TR21 and TR22 protein. TR21 and TR22 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to secreening methods for identifying agonists and antagonists of TR21 and TR22 activity; and methods of treating immune disorders by administering TR21 and TR22 polynucleotides, polypeptides, agonists, and antagonists.
摘要翻译: 本发明涉及作为肿瘤坏死因子(TNF)受体成员的两种新型蛋白质TR21和TR22。 特别地,提供编码人TR21和TR22蛋白的分离的核酸分子。 还提供TR21和TR22多肽,载体,宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定TR21和TR22活性的激动剂和拮抗剂的筛选方法; 以及通过施用TR21和TR22多核苷酸,多肽,激动剂和拮抗剂来治疗免疫疾病的方法。
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公开(公告)号:EP1044211A4
公开(公告)日:2005-03-23
申请号:EP99904021
申请日:1999-01-06
发明人: RUBEN STEVEN M , SOPPET DANIEL R , EBNER REINHARD , LAFLEUR DAVID W , NI JIAN , BREWER LAURIE A , OLSEN HENRIK S , DUAN ROXANNE D , ROSEN CRAIG A
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公开(公告)号:EP1385862A4
公开(公告)日:2005-03-02
申请号:EP02721715
申请日:2002-04-12
发明人: ROSEN CRAIG A , ALBERT VIVIAN R , RUBEN STEVEN M , WAGER RUTH E
CPC分类号: C07K14/52
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公开(公告)号:EP1251863A4
公开(公告)日:2005-03-02
申请号:EP01910340
申请日:2001-01-17
发明人: ROSEN CRAIG A , KOMATSOULIS GEORGE A , BAKER KEVIN P , BIRSE CHARLES E , SOPPET DANIEL R , OLSEN HENRIK S , MOORE PAUL A , WEI PING , EBNER REINHARD , DUAN D ROXANNE , SHI YANGGU , CHOI GIL H , FISCELLA MICHELE , NI JIAN , RUBEN STEVEN M , BARASH STEVEN C
IPC分类号: A61K38/00 , A61K48/00 , C07K14/47 , C07K14/705 , A61K31/7088 , A61K31/713 , A61K38/16 , A61K38/43 , A61K39/395 , C12N9/00 , C12N15/12 , C12N15/52 , C12Q1/68 , G01N33/53 , G01N33/68
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公开(公告)号:EP1088071A4
公开(公告)日:2005-03-02
申请号:EP99930252
申请日:1999-06-15
发明人: RUBEN STEVEN M , NI JIAN , ROSEN CRAIG A , WEI YING-FEI , YOUNG PAUL E , FLORENCE KIMBERLY A , SOPPET DANIEL R , BREWER LAURIE A , ENDRESS GREGORY A , CARTER KENNETH C , MUCENSKI MICHAEL , EBNER REINHARD , LAFLEUR DAVID W , OLSEN HENRIK S , SHI YANGGU , MOORE PAUL A , KOMATSOULIS GEORGE
IPC分类号: C12N15/09 , A61K38/00 , A61K39/395 , A61K48/00 , A61P43/00 , C07K7/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12Q1/68 , G01N33/68
CPC分类号: G01N33/6893 , A61K38/00 , C07K14/47 , G01N2500/20
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公开(公告)号:EP1317467A4
公开(公告)日:2004-12-22
申请号:EP01903079
申请日:2001-01-17
发明人: ROSEN CRAIG A , KOMATSOULIS GEORGE A , BAKER KEVIN P , BIRSE CHARLES E , SOPPET DANIEL R , OLSEN HENRIK S , MOORE PAUL A , WEI PING , EBNER REINHARD , DUAN D ROXANNE , SHI YANGGU , CHOI GIL H , FISCELLA MICHELE , NI JIAN
IPC分类号: C07K14/47 , C12N1/21 , C07H21/04 , C07H21/02 , C07K5/00 , C07K14/00 , C12N15/63 , C12N15/85 , C12N15/86 , C12Q1/68
CPC分类号: C07K14/47
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