利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

473 条记录 (耗时 0.046 秒)

    OLIGONUCLEOTIDES COMPRISING A LIGAND TETHERED TO A MODIFIED OR NON-NATURAL NUCLEOBASE
    76.
    发明公开
    OLIGONUCLEOTIDES COMPRISING A LIGAND TETHERED TO A MODIFIED OR NON-NATURAL NUCLEOBASE 有权
    WITH A寡核苷酸修改为或非天然的碱基拉尾配体

    公开(公告)号：EP1913011A2

    公开(公告)日：2008-04-23

    申请号：EP05857806.3

    申请日：2005-08-04

    申请人： Alnylam Pharmaceuticals Inc.

    发明人： MANOHARAN, Muthiah ,  RAJEEV, Kallanthottathil, G. ,  XIA, Jie

    IPC分类号： C07H21/00

    CPC分类号： C07H21/00 ,  A61K31/7115 ,  C07F9/6561 ,  C07H21/02 ,  C12Q1/6883 ,  Y02A50/385 ,  Y02A50/387 ,  Y02A50/393 ,  Y02A50/395 ,  Y02A50/411 ,  Y02A50/463 ,  Y02A50/465 ,  Y02A50/467

    摘要： One aspect of the present invention relates to a double-stranded oligonucleotide comprising at least one ligand tethered to an altered or non-natural nucleobase. In certain embodiments, the non-natural nucleobase is difluorotolyl, nitropyrrolyl, or nitroimidazolyl. In certain embodiments, the ligand is a steroid or aromatic compound. In certain embodiments, only one of the two oligonucleotide strands comprising the double-stranded oligonucleotide contains a ligand tethered to an altered or non-natural nucleobase. In certain embodiments, both of the oligonucleotide strands comprising the double-stranded oligonucleotide independently contain a ligand tethered to an altered or non-natural nucleobase. In certain embodiments, the oligonucleotide strands comprise at least one modified sugar moiety. Another aspect of the present invention relates to a single-stranded oligonucleotide comprising at least one ligand tethered to an altered or non-natural nucleobase. In certain embodiments, the non-natural nucleobase is difluorotolyl, nitropyrrolyl, or nitroimidazolyl. In certain embodiments, the ligand is a steroid or aromatic compound. In certain embodiments, the ribose sugar moiety that occurs naturally in nucleosides is replaced with a hexose sugar, polycyclic heteroalkyl ring, or cyclohexenyl group. In certain embodiments, at least one phosphate linkage in the oligonucleotide has been replaced with a phosphorothioate linkage.

    OLIGONUCLEOTIDES COMPRISING A MODIFIED OR NON-NATURAL NUCLEOBASE
    78.
    发明公开
    OLIGONUCLEOTIDES COMPRISING A MODIFIED OR NON-NATURAL NUCLEOBASE 审中-公开
    与修改或不自然的核酸OLIGONUCLEOTIDES

    公开(公告)号：EP1828215A2

    公开(公告)日：2007-09-05

    申请号：EP05857544.0

    申请日：2005-07-21

    申请人： Alnylam Pharmaceuticals Inc.

    发明人： MANOHARAN, Muthiah ,  XIA Jie ,  RAJEEV, Kallanthottathil, G.

    IPC分类号： C07H20060101

    CPC分类号： C07H21/00 ,  A61K31/7115 ,  C07F9/65515 ,  C07F9/65586 ,  C07F9/6561 ,  C07H21/02 ,  Y02A50/385 ,  Y02A50/387 ,  Y02A50/393 ,  Y02A50/395 ,  Y02A50/411 ,  Y02A50/463 ,  Y02A50/465 ,  Y02A50/467

    摘要： One aspect of the present invention relates to a double-stranded oligonucleotide comprising at least one non-natural nucleobase. In certain embodiments, the non-natural nucleobase is difluorotolyl, nitroindolyl, nitropyrrolyl, or nitroimidazolyl. In a preferred embodiment, the non-natural nucleobase is difluorotolyl. In certain embodiments, only one of the two oligonucleotide strands comprising the double-stranded oligonucleotide contains a non-natural nucleobase. In certain embodiments, both of the oligonucleotide strands comprising the double-stranded oligonucleotide independently contain a non-natural nucleobase. In certain embodiments, the oligonucleotide strands comprise at least one modified sugar moiety. Another aspect of the present invention relates to a single-stranded oligonucleotide comprising at least one non-natural nucleobase. In a preferred embodiment, the non-natural nucleobase is difluorotolyl. In certain embodiments, the ribose sugar moiety that occurs naturally in nucleosides is replaced with a hexose sugar, polycyclic heteroalkyl ring, or cyclohexenyl group. In certain embodiments, at least one phosphate linkage in the oligonucleotide has been replaced with a phosphorothioate linkage.