公开(公告)号：EP1587826A2

公开(公告)日：2005-10-26

申请号：EP04705707.0

申请日：2004-01-27

申请人： Wyeth Holdings Corporation

发明人： LIU, Dai-Fang ,  MCMICHAEL, John, Calhoun ,  BAKER, Steven, Morris ,  FLETCHER, Leah, Diane

IPC分类号： C07K14/21 ,  A61K39/385 ,  A61K39/02

CPC分类号： A61K39/1045 ,  A01K2217/05 ,  A61K2039/55505 ,  A61K2039/55572 ,  A61K2039/6037 ,  C07K14/47 ,  C07K14/4727 ,  C07K2319/00

摘要： The present invention broadly relates to immunogenic compositions for administering to a host susceptible to Moraxella catarrhalis infection. More particularly, the invention is directed to the identification of cross-reactive epitope sequences of the CopB protein of Moraxella catarrhalis.

公开(公告)号：EP0876150B1

公开(公告)日：2005-10-26

申请号：EP96942080.1

申请日：1996-11-27

申请人： UNIVERSITY OF IOWA RESEARCH FOUNDATION ,  The Regents of the University of California ,  Wyeth Holdings Corporation

发明人： APICELLA, Michael, A. ,  SUNSHINE, Melvin, G. ,  LEE, Na-Gyong ,  ARUMUGHAM, Rasappa ,  GIBSON, Bradford, W.

IPC分类号： A61K39/02

CPC分类号： A61K39/0275 ,  A61K39/0283 ,  A61K39/095 ,  A61K39/102 ,  A61K39/104 ,  A61K39/1045 ,  A61K39/105 ,  A61K2039/522 ,  A61K2039/55577 ,  A61K2039/70 ,  C12N9/1025 ,  C12N15/01 ,  C12R1/01 ,  Y02A50/47 ,  Y02A50/476 ,  Y02A50/482 ,  Y10S424/831

摘要： A method is provided for identifying, isolating, and producing htrB mutants of gram-negative bacterial pathogens. The method comprises mutating the htrB gene of a gram-negative bacterial pathogen so that there is a lack of a functional htrB protein, resulting in a mutant that lacks one or more secondary acyl chains contained in the wild type gram-negative bacterial pathogen, and displays substantially reduced toxicity as compared to the wild type strain. Also, the present invention provides methods for using a vaccine formulation containing the htrB mutant, the endotoxin isolated therefrom, or the endotoxin isolated therefrom which is then conjugated to a carrier protein, to immunize an individual against infections caused by gram-negative bacterial pathogens by administering a prophylactically effective amount of the vaccine formulation.

公开(公告)号：EP0876150A4

公开(公告)日：2002-01-30

申请号：EP96942080

申请日：1996-11-27

申请人： UNIV IOWA RES FOUND ,  UNIV CALIFORNIA ,  AMERICAN CYANAMID CO

发明人： APICELLA MICHAEL A ,  SUNSHINE MELVIN G ,  LEE NA-GYONG ,  ARUMUGHAM RASAPPA ,  GIBSON BRADFORD W

IPC分类号： C12N15/09 ,  A61K39/00 ,  A61K39/02 ,  A61K39/09 ,  A61K39/095 ,  A61K39/102 ,  A61K39/104 ,  A61K39/106 ,  A61K39/112 ,  A61K39/116 ,  A61P31/04 ,  C12N1/21 ,  C12N9/10 ,  C12N15/01 ,  C12R1/01

CPC分类号： A61K39/0275 ,  A61K39/0283 ,  A61K39/095 ,  A61K39/102 ,  A61K39/104 ,  A61K39/1045 ,  A61K39/105 ,  A61K2039/522 ,  A61K2039/55577 ,  A61K2039/70 ,  C12N9/1025 ,  C12N15/01 ,  C12R1/01 ,  Y10S424/831

摘要： A method is provided for identifying, isolating, and producing htrB mutants of gram-negative bacterial pathogens. The method comprises mutating the htrB gene of a gram-negative bacterial pathogen so that there is a lack of a functional htrB protein, resulting in a mutant that lacks one or more secondary acyl chains contained in the wild type gram-negative bacterial pathogen, and displays substantially reduced toxicity as compared to the wild type strain. Also, the present invention provides methods for using a vaccine formulation containing the htrB mutant, the endotoxin isolated therefrom, or the endotoxin isolated therefrom which is then conjugated to a carrier protein, to immunize an individual against infections caused by gram-negative bacterial pathogens by administering a prophylactically effective amount of the vaccine formulation.

公开(公告)号：EP0367757A1

公开(公告)日：1990-05-16

申请号：EP87903666.0

申请日：1987-05-22

申请人： Oread Pharmaceutical, Inc.

发明人： NELSON, Ralph ,  SCHLINK, Gerald

IPC分类号： A61K39

CPC分类号： A61K39/1045 ,  A61K39/0258 ,  A61K39/0275 ,  A61K39/102 ,  A61K39/39 ,  A61K2039/521 ,  A61K2039/55583 ,  A61K2039/55594 ,  A61K2039/70 ,  Y02A50/474 ,  Y02A50/482

摘要： A composition for co-injection of an animal against a gram-negative pathogen which comprises an effective dose of a gram-negative type lipopolysaccharide devoid of O-carbohydrate side-chains and a vaccine derived from said pathogen. Methods of co-injection of an animal to protect the animal against gram-negative pathogens.

公开(公告)号：EP4324526A3

公开(公告)日：2024-05-22

申请号：EP23205355.3

申请日：2011-07-26

申请人： Qu Biologics Inc.

发明人： Gunn,, Harold David ,  Dhanji,, Salim

IPC分类号： A61P43/00

CPC分类号： A61K39/0008 ,  A61K39/0258 ,  A61K39/0266 ,  A61K39/0275 ,  A61K39/085 ,  A61K39/092 ,  A61K2039/52120130101 ,  A61K2039/525220130101 ,  A61K2039/5820130101 ,  A61K2039/58520130101 ,  G01N33/569 ,  A61K39/05 ,  A61K39/095 ,  A61K39/102 ,  A61K2039/54220130101 ,  A61K2039/54520130101 ,  A61K2039/7020130101 ,  A61K39/1045 ,  A61P1/00 ,  A61P1/02 ,  A61P1/04 ,  A61P19/02 ,  A61P29/00 ,  A61P35/00 ,  A61P37/04 ,  A61P43/00 ,  Y02A50/30 ,  A61K39/464838 ,  A61K2239/4920230501 ,  A61K2239/5420230501 ,  A61K39/4615 ,  A61K39/4622 ,  A61K2239/5820230501 ,  A61P37/06 ,  A61K2039/5420130101 ,  A61K2039/57720130101

摘要： The invention provides methods of formulating an anti-inflammatory composition for treating inflammatory conditions in a specific organ or tissue. The method involves selecting at least one pathogen that is pathogenic in the specific organ or tissue; producing an antigenic composition comprising antigenic determinants that together are specific for the pathogen; and formulating the antigenic composition for administration as an anti-inflammatory composition capable of eliciting an anti-inflammatory response in the specific organ or tissue, wherein the condition characterized by inflammation is not a cancer. In embodiments of the invention, a cancer is situated in the specific organ or tissue.

公开(公告)号：EP3077512A4

公开(公告)日：2017-09-06

申请号：EP14866832

申请日：2014-12-01

申请人： SCHRYVERS ANTHONY B ,  MORAES TREVOR F ,  GRAY-OWEN SCOTT

发明人： SCHRYVERS ANTHONY B ,  MORAES TREVOR F ,  GRAY-OWEN SCOTT

IPC分类号： C12N15/31 ,  A61K39/02 ,  A61K39/095 ,  A61K39/102 ,  A61P31/04 ,  A61P37/04 ,  C07K14/195 ,  C07K14/22 ,  C07K14/285 ,  C12N15/63

CPC分类号： A61K39/1045 ,  A61K39/095 ,  A61K39/102 ,  A61K2039/523 ,  A61K2039/70 ,  C07K14/195 ,  C07K14/22 ,  C07K14/285

摘要： The disclosure provides immunogenic compositions comprising a polypeptide comprising a C-lobe domain or an N-lobe domain of a HIBP surface receptor protein obtainable from or obtained from a Gram-negative bacterial species. The HIBP surface receptor proteins have been modified in such a manner that they are unable to bind host iron binding protein. Methods of making and using these immunogenic positions to prepare animal and human vaccines are also provided.

摘要翻译： 本公开内容提供了包含多肽的免疫原性组合物，所述多肽包含可得自或获自革兰氏阴性细菌物种的HIBP表面受体蛋白的C-叶结构域或N-叶结构域。 HIBP表面受体蛋白已经以不能结合宿主铁结合蛋白的方式被修饰。 还提供了制备和使用这些免疫原性位置来制备动物和人类疫苗的方法。

公开(公告)号：EP2548884B1

公开(公告)日：2017-08-02

申请号：EP12189014.9

申请日：2006-08-08

申请人： Arne Forsgren AB

发明人： Forsgren, Arne ,  Riesbeck, Kristian

IPC分类号： C07K14/21 ,  A61K39/104 ,  A61P31/04

CPC分类号： A61K39/1045 ,  A61K39/02 ,  A61K39/104 ,  C07K14/195 ,  C07K14/212 ,  C07K14/78 ,  C07K19/00 ,  C12N15/09 ,  C12N15/101 ,  G01N30/02

公开(公告)号：EP3110438A1

公开(公告)日：2017-01-04

申请号：EP15708341.1

申请日：2015-02-20

申请人： GlaxoSmithKline Biologicals SA

发明人： BLAIS, Normand ,  CASTADO, Cindy ,  CHOMEZ, Patrick ,  DEWERCHIN, Marianne

IPC分类号： A61K39/00 ,  C07K16/12 ,  C07K14/21

CPC分类号： C07K14/212 ,  A61K39/102 ,  A61K39/1045 ,  A61K2039/55505 ,  A61K2039/55566 ,  A61K2039/55572 ,  A61K2039/55577 ,  A61K2039/70 ,  C07K16/1217

摘要： The present invention relates to compositions comprising Moraxella catarrhalis (M. catarrhalis) Ubiquitous surface protein A2 (UspA2). More particularly, the present application relates to UspA2 protein constructs and immunogenic compositions comprising the constructs, vaccines comprising such immunogenic compositions and therapeutic uses of the same. The invention further relates to compositions comprising UspA2 in combination with at least one antigen from Haemophilus influenzae, immunogenic compositions comprising the antigens, vaccines comprising such immunogenic compositions and therapeutic uses of the same.

摘要翻译： 本发明涉及包含卡他莫拉菌（卡他莫拉菌）泛素表面蛋白A2（UspA2）的组合物。 更具体地说，本申请涉及包含构建体的UspA2蛋白质构建体和免疫原性组合物，包含这种免疫原性组合物的疫苗及其治疗用途。 本发明还涉及包含UspA2与流感嗜血杆菌的至少一种抗原组合的组合物，包含抗原的免疫原性组合物，包含这种免疫原性组合物的疫苗及其治疗用途。

公开(公告)号：EP1913019B1

公开(公告)日：2014-12-31

申请号：EP06769599.9

申请日：2006-08-08

申请人： Arne Forsgren AB

发明人： FORSGREN, Arne ,  RIESBECK, Kristian

IPC分类号： C07K14/21 ,  A61K39/104 ,  A61P31/04

CPC分类号： A61K39/1045 ,  A61K39/02 ,  A61K39/104 ,  C07K14/195 ,  C07K14/212 ,  C07K14/78 ,  C07K19/00 ,  C12N15/09 ,  C12N15/101 ,  G01N30/02

公开(公告)号：EP2286832B1

公开(公告)日：2014-07-23

申请号：EP10075497.7

申请日：2005-05-30

申请人： Qu Biologics Inc

发明人： Gunn Harold D.

IPC分类号： A61K39/02 ,  A61P35/00 ,  A61K35/74 ,  A61P37/04

CPC分类号： A61K35/744 ,  A61K35/74 ,  A61K35/742 ,  A61K39/02 ,  A61K39/0258 ,  A61K39/0266 ,  A61K39/05 ,  A61K39/085 ,  A61K39/092 ,  A61K39/095 ,  A61K39/102 ,  A61K39/1045 ,  A61K2039/521 ,  A61K2039/585 ,  A61K2039/70 ,  Y02A50/474 ,  Y02A50/478 ,  Y02A50/48

摘要： A preparation of an antigen of one or more pathogenic bacterial species for use in treating a cancer in a specific organ, tissue or cell in a subject, wherein the pathogenic bacterial species is pathogenic in the corresponding specific organ, tissue or cell in a healthy subject. Suitably, the preparation comprises one or more attenuated bacteria.