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    METHOD FOR IMMOBILIZING AND RELEASING MICROORGANISM
    3.
    发明公开
    METHOD FOR IMMOBILIZING AND RELEASING MICROORGANISM 有权
    固定和释放微生物的方法

    公开(公告)号：EP2980211A1

    公开(公告)日：2016-02-03

    申请号：EP14773956.9

    申请日：2014-03-14

    申请人： National University Corporation Nagoya University

    发明人： HORI Katsutoshi

    IPC分类号： C12N11/00 ,  C12N1/21 ,  C12N15/09

    CPC分类号： C12N11/00 ,  C07K14/212 ,  C12N1/20 ,  C12N11/02 ,  C12N11/08 ,  C12N11/14

    摘要： Intended is to provide a more practical technique for immobilizing a microorganism using an adhesive protein AtaA derived from Acinetobacter sp. Tol 5. Provided is a method for attaching and releasing a microorganism, including (1) a step of contacting a microorganism, into which DNA encoding autotransporter adhesin derived from a microorganism belonging to the genus Acinetobacter has been introduced to impart or enhance non-specific adhesiveness, with a carrier under a high ionic strength and thus attaching the microorganism to the carrier; and (2) a step of releasing the microorganism from the carrier by washing under a low ionic strength.

    摘要翻译： 旨在提供一种更实用的技术，用于使用源自不动杆菌的粘附蛋白AtaA固定微生物。 5.提供了一种用于附着和释放微生物的方法，所述方法包括（1）使已经导入来自属于不动杆菌属的微生物的自编码转运蛋白粘附素的DNA的微生物接触以赋予或增强非特异性 与载体在高离子强度下粘附，从而将微生物附着到载体上; 和（2）通过在低离子强度下洗涤从载体释放微生物的步骤。

    MORAXELLA CATARRHALIS ANTIGENS
    6.
    发明公开
    MORAXELLA CATARRHALIS ANTIGENS 审中-公开
    MORAXELLA CATARRHALIS ANTIGENE

    公开(公告)号：EP2435063A2

    公开(公告)日：2012-04-04

    申请号：EP10727371.6

    申请日：2010-05-28

    申请人： Intercell AG

    发明人： VON GABAIN, Alexander ,  NAGY, Eszter ,  MEINKE, Andreas ,  SELAK, Sanja ,  HANNER, Markus ,  SMIDT, Margarita ,  FLOR, Julia ,  NOIGES, Birgit ,  SCHUELER, Wolfgang ,  SCHIRMER, Ulrike ,  SALLETMAYER, Verena ,  NEZHYBA, Mario ,  SEIDEL, Stefan ,  OLEKSIEWICZ, Martin

    IPC分类号： A61K38/04

    CPC分类号： C07K14/212 ,  A61K39/00

    摘要： The present invention relates to isolated nucleic acid molecules which encode an antigen from a Moraxella catarrhalis (Meat) species, a vector which comprises such nucleic acid molecule, and a host cell comprising such vector. Furthermore, the invention provides antigens from a Moraxella catarrhalis species, as well as fragments and variants thereof, a process for producing such antigens, and a process for producing a cell which expresses such antigen. More specifically, such antigens are produced by or associated with bacterial infections caused by Moraxella catarrhalis. Moreover, the present invention provides antibodies binding to such antigen, a hybridoma cell producing such antibodies, methods for producing such antibodies, a pharmaceutical composition comprising such nucleic acid molecule, antigen, vector or antibody, the use of such nucleic acid molecule, antigen, vector or antibody for the preparation of a pharmaceutical composition, methods for identifying an antagonist capable of binding such antigen or of reducing or inhibiting the interaction activity of such antigen, methods for diagnosing an infection with Moraxella catarrhalis and methods for the treatment or prevention of an infection with Moraxella catarrhalis.

    Species-specific, genus-specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial and fungal pathogens and associated antibiotic resistance genes from clinical specimens for diagnosis in microbiology laboratories
    7.
    发明公开
    Species-specific, genus-specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial and fungal pathogens and associated antibiotic resistance genes from clinical specimens for diagnosis in microbiology laboratories 失效
    Enteroccocus属特异性探针和扩增引物对临床标本的快速检测和鉴定

    公开(公告)号：EP2339033A1

    公开(公告)日：2011-06-29

    申请号：EP10181601.5

    申请日：1997-11-04

    申请人： Geneohm Sciences Canada, Inc.

    发明人： Bergeron, Michel G. ,  Picard, Francois ,  Ouellette, Marc ,  Roy, Paul H.

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/689 ,  C07K14/195 ,  C07K14/21 ,  C07K14/212 ,  C07K14/245 ,  C07K14/26 ,  C07K14/285 ,  C07K14/31 ,  C07K14/315 ,  C07K14/3156 ,  C12Q1/6895 ,  C12Q2600/156

    摘要： DNA-based methods employing amplification primers or probes for detecting, identifying, and quantifying in a test sample DNA from (i) any bacterium, (ii) the species Streptococcus agalactiae, Staphylococcus saprophyticus, Enterococcus faecium, Neisseria meningitidis, Listeria monocytogenes and Candida albicans, and (iii) any species of the genera Streptococcus, Staphylococcus, Enterococcus, Neisseria and Candida are disclosed. DNA-based methods employing amplification primers or probes for detecting, identifying, and quantifying in a test sample antibiotic resistance genes selected from the group consisting of bla tem , bla rob , bla shv , bla oxa , blaZ, aadB , aacC1, aacC2, aacC3, aacA4, aac6'-Ila , ermA, ermB, ermC, mecA, vanA, vanB, vanC, satA, aac(6)-aph(2''), aad(6') , vat, vga, msrA, sul and int are also disclosed. The above microbial species, genera and resistance genes arc all clinically relevant and commonly encountered in a variety of clinical specimens. These DNA-based assays are rapid, accurate and can be used in clinical microbiology laboratories for routine diagnosis. These novel diagnostic tools should be useful to improve the speed and accuracy of diagnosis of microbial infections, thereby allowing more effective treatments. Diagnostic kits for (i) the universal detection and quantification of bacteria, and/or (ii) the detection, identification and quantification of the above-mentioned bacterial and fungal species and/or genera, and/or (iii) the detection, identification and quantification of the above-mentioned antibiotic resistance genes arc also claimed.

    摘要翻译： 基于DNA的方法用人扩增引物或探针，用于检测，鉴定，和选自（i）的任何细菌，在一个测试样品DNA定量（ii）所述种类无乳链球菌，腐生葡萄球菌，屎肠球菌，脑膜炎奈瑟氏菌，李斯特菌和白色念珠菌 ，和（iii）各属链球菌，葡萄球菌，肠球菌属，奈瑟氏球菌属和念珠菌的任何种类游离缺失光盘。 基于DNA的方法用人扩增引物或探针，用于检测，鉴定，并在选自BLA TEM中选择的测试样品的抗生素抗性基因定量，血乳酸抢劫，BLA SHV，血乳酸氧杂，blaZ，aadB，aacC1，aacC2，aacC3 ，aacA4，aac6'-IIA，ERMA，ermB，ERMC，mecA基因，VANA，vanB，VANC，SATA AAC（6）-aph（2 ''），AAD（6“），大桶，VGA，MSRA，SUL和 所以INT是游离缺失盘。 以上微生物物种，属和抗性基因弧的所有临床相关并在各种临床标本中经常遇到的。 这些基于DNA的测定是快速，准确，并且可以在临床微生物学实验室进行常规诊断中使用。 这些新颖的诊断工具应该是提高速度和微生物感染的诊断精度，从而允许更有效的治疗是有用的。 为（i）所述通用检测和细菌的定量，和/或（ii）的检测，鉴定和上述细菌和真菌物种和/或属的定量，和/或（iii）检测，鉴定诊断试剂盒 和上述的抗生素抗性基因的定量弧这样声称。

    Species-specific, genus-specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial and fungal pathogens and associated antibiotic resistance genes from clinical specimens for diagnosis in microbiology laboratories
    8.
    发明公开
    Species-specific, genus-specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial and fungal pathogens and associated antibiotic resistance genes from clinical specimens for diagnosis in microbiology laboratories 失效
    李斯特菌特异性DNA探针和扩增引物对临床标本的快速检测和鉴定

    公开(公告)号：EP2336365A1

    公开(公告)日：2011-06-22

    申请号：EP10181604.9

    申请日：1997-11-04

    申请人： Geneohm Sciences Canada, Inc.

    发明人： Bergeron, Michel G. ,  Picard, Francois ,  Ouellette, Marc ,  Roy, Paul H.

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/689 ,  C07K14/195 ,  C07K14/21 ,  C07K14/212 ,  C07K14/245 ,  C07K14/26 ,  C07K14/285 ,  C07K14/31 ,  C07K14/315 ,  C07K14/3156 ,  C12Q1/6895 ,  C12Q2600/156

    摘要： DNA-based methods employing amplification primers or probes for detecting, identifying, and quantifying in a test sample DNA from (i) any bacterium, (ii) the species Streptococcus agalactiae, Staphylococcus saprophyticus, Enterococcus faecium, Neisseria meningitidis, Listeria monocytogenes and Candida albicans, and (iii) any species of the genera Streptococcus, Staphylococcus, Enterococcus, Neisseria and Candida are disclosed. DNA-based methods employing amplification primers or probes for detecting, identifying, and quantifying in a test sample antibiotic resistance genes selected from the group consisting of bla tem , bla rob , bla shv , bla oxa , blaZ, aadB, aacC1, aacC2, aacC3, aacA4, aac6' -//a, ermA, ermB, ermC, mecA, vanA, vanB, vanC, satA, aac(6')-aph(2'), aad(6), vat, vga, msrA, sul and int are also disclosed. The above microbial species, genera and resistance genes arc all clinically relevant and commonly encountered in a variety of clinical specimens. These DNA-based assays are rapid, accurate and can be used in clinical microbiology laboratories for routine diagnosis. These novel diagnostic tools should be useful to improve the speed and accuracy of diagnosis of microbial infections, thereby allowing more effective treatments. Diagnostic kits for (i) the universal detection and quantification of bacteria, and/or (ii) the detection, identification and quantification of the above-mentioned bacterial and fungal species and/or genera, and/or (iii) the detection, identification and quantification of the above-mentioned antibiotic resistance genes arc also claimed.

    摘要翻译： 基于DNA的方法用人扩增引物或探针，用于检测，鉴定，和选自（i）的任何细菌，在一个测试样品DNA定量（ii）所述种类无乳链球菌，腐生葡萄球菌，屎肠球菌，脑膜炎奈瑟氏菌，李斯特菌和白色念珠菌 ，和（iii）各属链球菌，葡萄球菌，肠球菌属，奈瑟氏球菌属和念珠菌的任何种类游离缺失光盘。 基于DNA的方法用人扩增引物或探针，用于检测，鉴定，并在选自BLA TEM中选择的测试样品的抗生素抗性基因定量，血乳酸抢劫，BLA SHV，血乳酸氧杂，blaZ，aadB，aacC1，aacC2，aacC3 ，aacA4，aac6 ' - //一个，ERMA，ermB，ERMC，mecA基因，VANA，vanB，VANC，SATA，AAC（6'） - APH（2“），AAD（6），还原，VGA，MSRA，SUL 所以INT的游离缺失盘。 以上微生物物种，属和抗性基因弧的所有临床相关并在各种临床标本中经常遇到的。 这些基于DNA的测定是快速，准确，并且可以在临床微生物学实验室进行常规诊断中使用。 这些新颖的诊断工具应该是提高速度和微生物感染的诊断精度，从而允许更有效的治疗是有用的。 为（i）所述通用检测和细菌的定量，和/或（ii）的检测，鉴定和上述细菌和真菌物种和/或属的定量，和/或（iii）检测，鉴定诊断试剂盒 和上述的抗生素抗性基因的定量弧这样声称。

    NUCLEIC ACID MOLECULES
    9.
    发明公开
    NUCLEIC ACID MOLECULES 有权
    对于长链正构烷烃降解酶编码Nukleinsäuremolekule

    公开(公告)号：EP2041285A2

    公开(公告)日：2009-04-01

    申请号：EP07733352.4

    申请日：2007-06-25

    申请人： StatoilHydro ASA

    发明人： KOTLAR, Hans, Kristian ,  ELLINGSEN, Trond ,  ZOTCHEV, Sergey ,  WENTZEL, Alexander ,  THRONE-HOLST, Mimmi

    IPC分类号： C12N15/53 ,  C12N9/02 ,  C12N1/21 ,  C10G32/00

    CPC分类号： C07K14/212 ,  C12N9/0071

    摘要： Provided is a nucleic acid molecule comprising the sequence is set forth in SEQ ID NO:1, the corresponding protein sequence as set forth in SEQ ID NO:2, and variants and functional fragments thereof. Corresponding chimeric genes, vectors and microorganisms are also provided. The protein has a role in the degradation of long-chain n-alkanes and can be used to modify the properties of long-chain n- alkane containing substrates. Methods of using the protein of the invention, e.g. to cause degradation of long-chain n-alkanes are also provided, as are methods of identifying enzymes that are required for the metabolism of a substrate.