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公开(公告)号：EP3097078A4
公开(公告)日：2017-11-29
申请号：EP15739774
申请日：2015-01-23
申请人： PURDUE PHARMA LP
发明人： LYNCH STEPHEN M
IPC分类号： C07D211/10 , A61K31/44 , A61K31/551 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/04 , C07D405/14 , C07D413/04 , C07D413/14
CPC分类号： C07D413/14 , C07B59/002 , C07B2200/05 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/04 , C07D405/14 , C07D413/04
摘要： The present disclosure provides pyridines and pyrimidines of Formula I and pharmaceutically acceptable salts and solvates thereof: wherein A, G, W1, W2, W3, and R5 are defined as set forth in the specification. The present disclosure also provides uses of the compounds of Formula I and pharmaceutically acceptable salts and solvates thereof. In certain embodiments, Compounds of the present disclosure are useful for treating pain. In another embodiment, Compounds of the present disclosure are useful for treating a disorder responsive to blockade of sodium channels, or alleviating symptoms of the disorder.
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公开(公告)号：EP2967067B1
公开(公告)日：2017-11-29
申请号：EP14767374.3
申请日：2014-03-14
IPC分类号： A01N43/82 , C07D413/06
CPC分类号： C07D413/04 , A01N43/82
摘要： Provided herein are new 3,5-disubstituted-1,3,4-oxadiazol-2(3H)-ones and derivatives thereof that exhibit nematicidal activity and are useful, for example, in methods for the control of unwanted nematodes.
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公开(公告)号：EP2786994B1
公开(公告)日：2017-11-22
申请号：EP14167108.1
申请日：2008-08-13
发明人： Williams, Deryck J. , Dimmic, Matt W. , Haakenson, William P., Jr. , Wideman, Al , Shortt, Barry J. , Cheeseright, Tim , Crawford, Michael J.
IPC分类号： C07D413/04 , C07D417/04 , A01N43/76 , A01N43/82 , A01P5/00
CPC分类号： A01N43/22 , A01N43/56 , A01N43/76 , A01N43/78 , A01N43/82 , A01N47/12 , A01N57/28 , A01N57/30 , A01N57/32 , C07D405/04 , C07D413/04 , C07D413/14 , C07D417/04
摘要： Compositions and processes for controlling nematodes are described herein, e.g., nematodes that infest plants or animals. The compounds 1,2,4-thiadiazole derivatives.
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公开(公告)号：EP2786993B1
公开(公告)日：2017-11-15
申请号：EP14167106.5
申请日：2008-08-13
发明人： Williams, Deryck J. , Dimmic, Matt W. , Haakenson, William P., Jr. , Wideman, Al , Short, Barry J. , Cheeseright, Tim , Crawford, Michael J.
IPC分类号： C07D413/04 , C07D417/04 , A01N43/76 , A01N43/82 , A01P5/00
CPC分类号： A01N43/22 , A01N43/56 , A01N43/76 , A01N43/78 , A01N43/82 , A01N47/12 , A01N57/28 , A01N57/30 , A01N57/32 , C07D405/04 , C07D413/04 , C07D413/14 , C07D417/04
摘要： Compositions and processes for controlling nematodes are described herein, e.g., nematodes that infest plants or animals. The compounds 1,2,4-thiadiazole derivatives.
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75.发明授权NEW MACROCYCLIC AMIDINOUREA DERIVATIVES, METHODS OF PREPARATION AND USES THEREOF AS CHITINASE INHIBITORS 有权新型大环酰氨基脲衍生物，其制备方法及其用作CHITINASE抑制剂的用途
公开(公告)号：EP3010896B1
公开(公告)日：2017-11-01
申请号：EP14731625.1
申请日：2014-06-18
发明人： SANFILIPPO, Stefania , POSTERARO, Brunella , SANGUINETTI, Maurizio , BOTTA, Maurizio , MACCARI, Giorgio , DE LUCA, Filomena , DOCQUIER, Jean-Denis , DEODATO, Davide
IPC分类号： C07D273/00 , C07D413/04 , A61K31/395 , A61P31/10 , A61P11/06 , C07C271/20 , C07C279/24
CPC分类号： C07D273/00 , A61K31/395 , A61K31/4192 , A61K45/06 , C07C271/20 , C07C279/24 , C07D413/04
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76.发明授权IL17 AND IFN-GAMMA INHIBITION FOR THE TREATMENT OF AUTOIMMUNE INFLAMMATION 有权IL17和IFN-γ抑制剂治疗自身免疫性炎症
公开(公告)号：EP2668183B1
公开(公告)日：2017-11-01
申请号：EP12703014.6
申请日：2012-01-27
申请人： 4SC Discovery GmbH
发明人： LEBAN, Johann , TASLER, Stefan , SAEB, Wael , CHEVRIER, Carine
IPC分类号： C07D413/04 , C07D413/14 , C07D417/14 , A61K31/4155 , A61P19/00 , A61P29/00
CPC分类号： C07D413/04 , C07D413/14 , C07D417/14
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公开(公告)号：EP3235818A2
公开(公告)日：2017-10-25
申请号：EP17171615.2
申请日：2011-04-01
IPC分类号： C07D471/04 , A61K31/506 , A61K31/519 , A61P31/18 , C07D239/36 , C07D413/04 , C07D239/40 , C07D239/42
CPC分类号： C07D471/04 , C07D239/36 , C07D239/40 , C07D239/42 , C07D239/47 , C07D239/557 , C07D239/56 , C07D413/04 , C07D487/04
摘要： The invention relates to a compound of Formula II:
a pharmaceutically-acceptable salt, hydrate, solvate, tautomer, optical isomer, E-isomer, Z-isomer, or combination thereof; X is selected from Se, N-OH, NH, NO 2 , CN, N-CN, N=O, O or S, and the remaining substituents are described herein; and a composition thereof. The invention also relates to a method of administration thereof; and use thereof to treat HIV.-
78.发明公开3-(PIPERIDIN-4-YL)-ISOXAZOL-3(2H)-ONES FOR TREATMENT OF DERMATOLOGIC DISORDERS 审中-公开3-（哌啶-4-基） - 恶唑-3（2H） - 酮用于治疗皮肤病
公开(公告)号：EP3233189A1
公开(公告)日：2017-10-25
申请号：EP15832756.9
申请日：2015-12-18
申请人： Emeriti Pharma AB
发明人： FEX, Tomas , GUSTAFSSON, Nils David
CPC分类号： A61K31/454 , A61K9/0014 , A61K9/06 , A61K45/06 , A61K47/06 , A61K2300/00 , A61Q1/02 , C07D413/04
摘要： Described are a group of isoxazol-3(2H)-one analogues and their use in topical formulations for the treatment and prophylaxis of dermatological disorders.
摘要翻译： 描述了一组异恶唑-3（2H） - 酮类似物及其在用于治疗和预防皮肤疾病的局部制剂中的用途。
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公开(公告)号：EP3230277A1
公开(公告)日：2017-10-18
申请号：EP15866917.6
申请日：2015-12-11
IPC分类号： C07D403/14 , A61K31/4196 , A61K31/4439 , A61K31/4985 , C07D401/14 , C07D403/04 , C07D413/14
CPC分类号： A61K31/4184 , A61K31/4196 , A61K31/42 , A61K31/437 , A61K31/4439 , A61K31/4545 , A61K31/496 , A61K31/498 , A61K31/4985 , A61K31/517 , A61K31/52 , A61K31/5377 , A61K45/06 , A61K2300/00 , A61P35/00 , A61P37/00 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/04 , C07D413/14 , C07D471/04 , C07D473/34 , Y02A50/467
摘要： The present application relates to substituted heterocycles compound of Formula I and pharmaceutical compositions thereof useful for the inhibition of BET protein function by binding to bromodomains (Formula I).
摘要翻译： 本申请涉及式I的取代杂环化合物及其药物组合物，其可用于通过结合溴结构域（式I）来抑制BET蛋白功能。
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公开(公告)号：EP2230913B1
公开(公告)日：2017-10-18
申请号：EP08861788.1
申请日：2008-12-18
IPC分类号： C07D413/12 , A01N43/80 , A01N47/20 , C07D413/04 , C07D417/12 , C07D261/08
CPC分类号： A01N43/80 , A01N47/20 , C07D261/08 , C07D413/04 , C07D413/12 , C07D417/12
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