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    METHOD FOR SILICA MONOLITH CLADDING AND SEPARATION MEDIUM
    75.
    发明公开
    METHOD FOR SILICA MONOLITH CLADDING AND SEPARATION MEDIUM 审中-公开
    VERFAHREN ZURUMHÜLLUNGVON硅氧化物在TRENNMEDIUM

    公开(公告)号：EP2246299A1

    公开(公告)日：2010-11-03

    申请号：EP08710958.3

    申请日：2008-02-01

    申请人： GL Sciences Incorporated

    发明人： MIYAZAKI, Shota ,  TERASHIMA, Hiroyuki ,  NYUDO, Masahiko ,  OHIRA, Masayoshi ,  MORISATO, Kei ,  FURUNO, Masahiro

    IPC分类号： C01B33/12 ,  B01D15/08 ,  B01J20/10 ,  B01J20/28 ,  B01J20/32 ,  G01N30/88

    CPC分类号： B01D15/22 ,  B01D15/20 ,  B01J20/103 ,  B01J20/28042 ,  B01J20/283 ,  B01J20/3257 ,  B01J2220/54 ,  B01J2220/82 ,  B01J2220/825 ,  G01N30/50 ,  G01N30/6052 ,  G01N2030/528

    摘要： To use a monolithic silica body in chromatography with a HPLC column or a GC column and to simplify the use thereof as a separation medium, it is intended to provide a method of cladding a main body of a monolithic adsorbent or separating agent with glass so as to protect the outer surface, and to provide a separation medium prepared by the method. To this end, a monolithic silica body alone is formed by molding, and the molding is coated with a glass body; and then the glass body and the monolithic silica body are fused and integrated at the melting temperature of the glass body at an appropriate pressure. The surface of the resulting monolithic silica body clad with glass is strongly protected by the glass, and the homogeneity of the interior of the monolithic silica body is maintained, and thus uniform flow of a sample solution ensures analytical accuracy.

    摘要翻译： 为了在使用HPLC柱或GC色谱柱的色谱法中使用整体式二氧化硅体，并且为了简化其作为分离介质的用途，旨在提供一种用玻璃包覆整体式吸附剂或分离剂的主体的方法，以便 以保护外表面，并提供通过该方法制备的分离介质。 为此，单独的整体式二氧化硅体通过成型而形成，成型用玻璃体涂布; 然后玻璃体和整体式二氧化硅体在玻璃体的熔融温度下以适当的压力熔融并整合。 用玻璃覆盖的所得整体二氧化硅体的表面被玻璃强烈保护，并且保持了整体二氧化硅体内部的均匀性，因此样品溶液的均匀流动确保了分析精度。

    CHROMATOGRAPHIC SEPARATION OF SUBSTANCES CONTAINED IN A LIQUID SAMPLE
    78.
    发明授权
    CHROMATOGRAPHIC SEPARATION OF SUBSTANCES CONTAINED IN A LIQUID SAMPLE 有权
    液体在测试含有化学物质色谱分离

    公开(公告)号：EP1608449B1

    公开(公告)日：2009-02-18

    申请号：EP04725224.2

    申请日：2004-04-01

    申请人： Protista Biotechnology AB

    发明人： MATTIASSON, Bo ,  GALAEV, Igor, Yu ,  HATTI KAUL, Rajni

    IPC分类号： B01D15/08 ,  G01N30/60 ,  B01L3/00

    CPC分类号： B01J20/28047 ,  B01D15/1864 ,  B01J20/28042 ,  B01J20/28054 ,  B01J20/285 ,  B01J20/291 ,  B01L3/5025 ,  G01N30/466 ,  G01N2030/528

    摘要： A method for the chromatographic separation of substances contained in a liquid sample is disclosed which method comprises providing a one piece separation tray having a spaced array of discrete identical upstanding chambers each exhibiting an open upper end and an open lower end and a separation medium placed in at least part of each upstanding chamber; applying a liquid sample to said open upper end of at least one of said upstanding chambers; then applying an eluting liquid to said open upper end of said at least one of said upstanding chambers; and collecting at least one product fraction flowing out from the open lower end of said at least one of said upstanding chambers; wherein a monolith of a compressible macroporous gel having in its liquid-swollen, non-compressed state a cross-sectional area which is 2-15 %, preferably 4-12 % and most preferably 5-10 %, larger than the cross-sectional area of the upstanding chamber in which it is placed is used as said separation medium and is in face-to-face contact with the wall of the respective chamber in its liquid-swollen state. Processes for the preparation of monoliths to be used in such a method and a separation device for use in said method are also disclosed.

    CHROMATOGRAPHY METHOD
    79.
    发明授权
    CHROMATOGRAPHY METHOD 失效
    色谱方法

    公开(公告)号：EP0442977B9

    公开(公告)日：2008-02-27

    申请号：EP90903657.6

    申请日：1990-02-20

    申请人： PERSEPTIVE BIOSYSTEMS, INC.

    发明人： AFEYAN, Noubar, B. ,  REGNIER, Fred, E. ,  DEAN, Robert, C., Jr.

    IPC分类号： B01D15/34 ,  B01J20/282

    CPC分类号： B01J20/282 ,  B01D15/345 ,  B01J20/28095 ,  B01J2220/54 ,  G01N2030/528

    摘要： Disclosed are chromatography methods and matrix geometries which permit high resolution, high productivity separation of mixtures of solutes, particularly biological materials. The method involves passing fluids through specially designed chromatography matrices at high flow rates. The matrices define first and second interconnected sets of pores and a high surface area for solute interaction in fluid communication with the members of the second set of pores (14). The first and second sets of pores are embodied, for example, as the interstices among particles and throughpores (14) within the particles. The pores are dimensioned such that, at achievable high fluid flow rates, convective flow occurs in both pore sets, and the convective flow rate exceeds the rate of solute diffusion in the second pore set. This approach couples convective and diffusive mass transport to and from the active surface and permits increases in fluid velocity without the normally expected bandspreading.