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    PORTABLE ELECTRONIC SYSTEM FOR THE ANALYSIS OF TIME-VARIABLE GASEOUS FLOWS
    2.
    发明公开
    PORTABLE ELECTRONIC SYSTEM FOR THE ANALYSIS OF TIME-VARIABLE GASEOUS FLOWS 审中-公开
    便携式电子系统用于分析时变气体流动

    公开(公告)号：EP3167270A1

    公开(公告)日：2017-05-17

    申请号：EP15753766.3

    申请日：2015-07-02

    Applicant: Nanotech Analysis S.r.l.s.

    Inventor： MENSA, Gianpiero ,  CORREALE, Raffaele

    IPC: G01N1/22 ,  H01J49/04 ,  B01L3/00 ,  H01J49/00 ,  G01N30/72

    CPC classification number: G01N30/722 ,  G01N30/7206 ,  H01J49/0018 ,  H01J49/0427

    Abstract: A portable system 1 for analyzing gaseous flows that vary over time is described, the system comprising a sampling chamber 18, a gas sampling module 7, an ion filtering module 8 and an ion detecting module 9. The sampling chamber 18 is suitable to be kept at a controlled sampling pressure Pc, and is configured to receive at least one gaseous flow F having a gaseous composition to be analyzed that is variable over time. The gas sampling module 7, arranged in fluidic communication with the sampling chamber 18, is configured to adjust an input gaseous flow Fi of gas particles from the sampling chamber 18, and an output gaseous flow Fo from the sampling module 7, so as to reproduce inside the sampling module 7 a gaseous composition representative of the gaseous composition to be analyzed. The gas sampling module 7 is further configured to ionize said gas particles and to emit the produced ions, so as to generate an ion flow I having an ion composition representative of the gaseous composition to be analyzed. The sampling module 7 is also suitable to maintain inside it a controlled ionization pressure Pi, and it is also configured in such a way that the input gaseous flow Fi comprises a plurality of micro-flows at a molecular or predominantly molecular regime, at the sampling pressure Pc, and the output gaseous flow Fo is a flow at a molecular or predominantly molecular regime, at the ionization pressure Pi. The ion filtering module 8 is operatively connected to the sampling module 7 to receive the ion flow I, and is configured to controllably select at least one type of ion present in the ion flow I and to generate a corresponding at least one homogeneous ion beam I′, having an intensity representative of the concentration of the corresponding gas particle in the gaseous composition to be analyzed. The ion detecting module 9 is operatively connected to the ion filtering module 8 to receive the at least one ion beam I′, and is configured to measure the intensity of the at least one ion beam I′ and to generate a corresponding electric signal S representative of the concentration of the corresponding gas particle in the gaseous composition to be analyzed.

    Abstract translation: 描述了用于分析随时间变化的气流的便携式系统1，该系统包括采样室18，气体采样模块7，离子过滤模块8和离子检测模块9.采样室18适于保持 处于受控采样压力Pc处，并且被配置成接收具有随时间变化的待分析气体组分的至少一个气流F. 布置成与采样室18流体连通的气体采样模块7构造成调节来自采样室18的气体颗粒的输入气体流量Fi和来自采样模块7的输出气体流量Fo，以便再现 在采样模块7内部提供代表待分析气体组合物的气态组合物。 气体采样模块7还被配置为将所述气体粒子离子化并发射产生的离子，以便产生具有代表待分析气体组分的离子组成的离子流I. 采样模块7也适合于在其内部保持受控的电离压力P 1，并且其还被配置为使得输入气体流量F 1在分子或主要分子状态下包括多个微流量 压力Pc，并且输出气体流量Fo是在电离压力Pi下的分子或主要分子状态下的流量。 离子过滤模块8可操作地连接到采样模块7以接收离子流I，并且被配置为可控制地选择存在于离子流I中的至少一种类型的离子并且生成相应的至少一个均匀离子束I '，具有代表待分析气体组合物中相应气体颗粒浓度的强度。 离子检测模块9可操作地连接到离子过滤模块8以接收至少一个离子束I'，并且被配置为测量至少一个离子束I'的强度并且产生相应的电信号S代表 的待分析气体组合物中相应气体颗粒的浓度。

    MICROCHIP AND WEDGE ION FUNNELS AND PLANAR ION BEAM ANALYZERS USING SAME
    6.
    发明公开
    MICROCHIP AND WEDGE ION FUNNELS AND PLANAR ION BEAM ANALYZERS USING SAME 审中-公开
    MICROCHIP和WEDGE离子漏斗和平面离子束分析仪使用相同

    公开(公告)号：EP2697818A1

    公开(公告)日：2014-02-19

    申请号：EP12702352.1

    申请日：2012-01-13

    Applicant: Battelle Memorial Institute

    Inventor： SHVARTSBURG, Alexandre A. ,  ANDERSON, Gordon A. ,  SMITH, Richard D.

    IPC: H01J49/00 ,  H01J49/06

    CPC classification number: H01J49/0018 ,  H01J49/066

    Abstract: Electrodynamic ion funnels confine, guide, or focus ions in gases using the Dehmelt potential of oscillatory electric field. New funnel designs operating at or close to atmospheric gas pressure are described. Effective ion focusing at such pressures is enabled by fields of extreme amplitude and frequency, allowed in microscopic gaps that have much higher electrical breakdown thresholds in any gas than the macroscopic gaps of present funnels. The new microscopic-gap funnels are useful for interfacing atmospheric-pressure ionization sources to mass spectrometry (MS) and ion mobility separation (IMS) stages including differential IMS or FAIMS, as well as IMS and MS stages in various configurations. In particular, "wedge" funnels comprising two planar surfaces positioned at an angle and wedge funnel traps derived therefrom can compress ion beams in one dimension, producing narrow belt-shaped beams and laterally elongated cuboid packets. This beam profile reduces the ion density and thus space-charge effects, mitigating the adverse impact thereof on the resolving power, measurement accuracy, and dynamic range of MS and IMS analyzers, while a greater overlap with coplanar light or particle beams can benefit spectroscopic methods.

    Abstract translation: 电动离子漏斗利用振荡电场的Dehmelt电势来限制，引导或集中离子在气体中。 描述了以大气压力或接近大气压力运行的新漏斗设计。 在这样的压力下有效的离子聚焦通过极大幅度和频率的场来实现，允许在任何气体中具有比当前漏斗的宏观间隙高得多的电击穿阈值的微观间隙。 新的微观漏斗可用于将大气压电离源连接到质谱（MS）和离子迁移分离（IMS）阶段，包括差异IMS或FAIMS，以及各种配置中的IMS和MS阶段。 具体地说，包括以一定角度定位的两个平面表面和由其衍生的楔形漏斗陷阱的“楔形”漏斗可以在一个维度上压缩离子束，从而产生窄的带形梁和横向伸长的长方体包。 该光束轮廓降低了离子密度和空间电荷效应，减轻了其对MS和IMS分析仪的分辨能力，测量精度和动态范围的不利影响，而与共面光或粒子束更大的重叠可以有利于光谱方法 。

    Micro-réflectron pour spectromètre de masse à temps de vol
    8.
    发明公开
    Micro-réflectron pour spectromètre de masse à temps de vol 有权
    Mikro-ReflektronfürFlugzeit-Massenspektrometer

    公开(公告)号：EP2485243A1

    公开(公告)日：2012-08-08

    申请号：EP12153896.1

    申请日：2012-02-03

    Applicant: Commissariat à l'Énergie Atomique et aux Énergies Alternatives

    Inventor： Danel, Jean-Sébastien ,  Duraffourg, Laurent ,  Progent, Frédéric ,  Tassetti, Charles-Marie

    IPC: H01J49/40 ,  B81B7/02

    CPC classification number: H01J49/405 ,  B05D3/10 ,  B81C1/00119 ,  B81C2201/0133 ,  B81C2203/031 ,  H01J49/0018

    Abstract: L'invention concerne un micro-réflectron pour spectromètre de masse à temps de vol comprenant un substrat (3100, 5400), et, intégrés au volume du substrat, des moyens (5400) d'application d'un gradient de potentiel dans un volume adapté à constituer une zone de vol des ions (3300 ), caractérisé en ce que lesdits moyens d'application comprennent au moins deux électrodes de polarisation et une paroi en au moins un matériau résistif adaptée à être polarisée entre ces électrodes en sorte de générer un gradient continu de potentiel en assurant elle-même la fonction de réflectron, cette zone de vol, ces électrodes et cette paroi étant obtenues par la technologie des systèmes micro-électromécaniques (MEMS) et ce micro-réflectron ayant une épaisseur inférieure à 5 millimètres tandis que ses autres dimension sont inférieures à 10 fois cette épaisseur.

    Abstract translation: 微反射器具有电位梯度施加单元，例如， 电阻层（5400），用于在形成离子飞行区的基底体积中施加电位梯度，例如 管（3300），其中微反射器的厚度小于5mm，其他尺寸小于厚度的10倍。 该单元包括由电阻材料制成的壁，并且在金属极化电极（5210）之间极化，以产生连续的电势梯度，同时提供反射器功能。 通过微机电系统技术获得区域，电极和壁。 还包括以下独立权利要求：（1）质谱仪（2）微反射镜的制造方法。

    MULTIPLE ELECTROSPRAY DEVICE, SYSTEMS AND METHODS
    9.
    发明授权
    MULTIPLE ELECTROSPRAY DEVICE, SYSTEMS AND METHODS 有权
    多电喷涂设备，系统和方法

    公开(公告)号：EP1269518B1

    公开(公告)日：2011-12-21

    申请号：EP00988285.3

    申请日：2000-12-22

    Applicant: Advion BioSystems, Inc.

    Inventor： SCHULTZ, Gary, A. ,  CORSO, Thomas, N. ,  PROSSER, Simon, J.

    IPC: H01J49/16

    CPC classification number: H01J49/167 ,  H01J49/0018 ,  H01J49/04

    Abstract: A microchip-based electrospray device, system, and method of fabrication thereof are disclosed. The electrospray device (250) includes a substrate (200) defining a channel (224) between an entrance orifice on an injection surface and an exit orifice on an ejection surface, a nozzle (232) defined by a portion recessed from the ejection surface surrounding the exit orifice, and an electric field generating source for application of an electric potential to the substrate to optimize and generate an electrospray (262). A method and system are disclosed to generate multiple electrospray plumes from a single fluid stream that provides an ion intensity as measured by a mass spectrometer that is approximately proportional to the number of electrospray plumes formed for analytes contained within the fluid. A plurality of electrospray nozzle devices (232) can be used in the form of an array of miniaturized nozzles for the purpose of generating multiple electrospray plumes (262) from multiple nozzles (232) for the same fluid stream . This invention dramatically increases the sensitivity of microchip electrospray devices (250) compared to prior disclosed systems and methods.

    Microengineered multipole ion guide
    10.
    发明公开
    Microengineered multipole ion guide 有权
    Mikromechanischer mehrpoliger Ionenleiter

    公开(公告)号：EP2372745A2

    公开(公告)日：2011-10-05

    申请号：EP11159009.7

    申请日：2011-03-21

    Applicant: Microsaic Systems PLC

    Inventor： Wright, Steven ,  O'Prey, Shane Martin

    IPC: H01J49/06

    CPC classification number: H01J49/063 ,  H01J49/0018

    Abstract: A microengineered multipole ion guide for use in miniature mass spectrometer systems is described. Exemplary methods of mounting rods in hexapole, octupole, and other multipole geometries are described. The rods forming the ion guide are supported in etched silicon structures defined in at least first and second substrates.

    Abstract translation: 描述了用于微型质谱仪系统的微型工程多极离子导向器。 描述了将杆安装在六极，八极和其他多极几何形状中的示例性方法。 形成离子导向件的杆被支撑在限定在至少第一和第二基板中的蚀刻硅结构中。

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