公开(公告)号：EP4223319A2

公开(公告)日：2023-08-09

申请号：EP23166601.7

申请日：2018-05-25

申请人： MedImmune, LLC ,  The Regents of the University of California

发明人： CHRISTIE, Ronald James ,  GAO, Changshou ,  ST. AMANT, Andre Henri ,  DE ALANIZ, Javier Read

IPC分类号： A61K47/68 ,  C07D249/12 ,  C07K1/13 ,  C07K1/107 ,  C07C233/52 ,  C07C247/10 ,  C07C247/12 ,  C07C271/22 ,  C07D307/58 ,  A61P35/00 ,  A61K47/69 ,  A61P29/00 ,  C07C233/48

摘要： The present invention provides a bioconjugation method and compounds for use therein. The bioconjugation method comprises the step of conjugating a biological molecule containing a first unsaturated functional group with a payload comprising a second unsaturated functional group, wherein the first and second unsaturated functional groups are complementary to each other such that conjugation is a reaction of said functional groups via a Diels-Alder reaction which forms a cyclohexene ring.

公开(公告)号：EP3052471B1

公开(公告)日：2023-06-21

申请号：EP14848810.9

申请日：2014-09-30

发明人： BECKER, Matthew ,  LIN, Fei

IPC分类号： C07C229/00 ,  C08G63/91 ,  C08G75/02 ,  C08G77/04 ,  C09D175/02 ,  C08G71/02 ,  C07C227/18 ,  C07C225/16 ,  C07C229/34 ,  C07C247/04 ,  A61L27/00 ,  A61L31/00 ,  C07C275/16

公开(公告)号：EP3990023A1

公开(公告)日：2022-05-04

申请号：EP20735317.8

申请日：2020-06-25

申请人： The University Of Bath

发明人： WATTS, Andrew ,  ALKHAWAJA, Bayan

IPC分类号： A61K47/00 ,  C07K16/00 ,  C07C233/00 ,  C07C247/04

公开(公告)号：EP3584255B1

公开(公告)日：2022-02-16

申请号：EP19168498.4

申请日：2013-08-30

发明人： STAFFORD, Ryan ,  YANG, Wenjin ,  THANOS, Christopher D.

IPC分类号： C07K14/535 ,  C07C247/00 ,  C07K14/00

公开(公告)号：EP3923974A1

公开(公告)日：2021-12-22

申请号：EP20752515.5

申请日：2020-02-05

申请人： Synthorx, Inc.

发明人： PTACIN, Jerod ,  CAFFARO, Carolina E. ,  MILLA, Marcos

IPC分类号： A61K38/20 ,  C07K14/55 ,  C07C247/04

公开(公告)号：EP3814304A1

公开(公告)日：2021-05-05

申请号：EP19733070.7

申请日：2019-06-28

申请人： Rheinische Friedrich-Wilhelms-Universität Bonn

发明人： THIELE, Christoph

IPC分类号： C07B59/00 ,  C07D249/04 ,  C07D487/04 ,  C07C247/04 ,  G01N33/68

公开(公告)号：EP2722322B8

公开(公告)日：2020-03-11

申请号：EP12799827.6

申请日：2012-06-18

申请人： Korea Research Institute of Chemical Technology ,  Katholieke Universiteit Leuven K.U. Leuven R&D

发明人： JUNG, Young Sik ,  LEE, Chong Kgo ,  CHOI, Ihl Young ,  KIM, Hae Soo ,  KIM, Pil Ho ,  HAN, Soo Bong ,  NEYTS, Johan ,  THIBAUT, Hendrik Jan

IPC分类号： C07C69/16 ,  A61P31/12 ,  C07C69/54 ,  C07C271/24 ,  C07C205/45 ,  C07D213/65 ,  C07C225/20 ,  C07C233/32 ,  C07C247/14 ,  C07C49/747 ,  A61K31/04 ,  A61K31/47

公开(公告)号：EP3611158A1

公开(公告)日：2020-02-19

申请号：EP19179546.7

申请日：2012-06-18

申请人： Korea Research Institute of Chemical Technology ,  Katholieke Universiteit Leuven

发明人： JUNG, Young Sik ,  LEE, Chong Kgo ,  CHOI, Ihl Young ,  KIM, Hae Soo ,  KIM, Pil Ho ,  HAN, Soo Bong ,  NEYTS, Johan ,  THIBAUT, Hendrik Jan

IPC分类号： C07C69/16 ,  C07C69/54 ,  C07C271/24 ,  C07C205/45 ,  C07D213/65 ,  C07C225/20 ,  C07C233/32 ,  C07C247/14 ,  C07C49/747 ,  A61P31/12 ,  A61K31/04 ,  A61K31/47

摘要： Disclosed are 1,3-Dioxoindene derivatives of Formula 1, pharmaceutically acceptable salts thereof or enantiomers, a preparation method thereof, and a pharmaceutical composition for the prevention or treatment of viral diseases, comprising the same as an active ingredient. The 1,3-Dioxoindene derivatives have excellent inhibitory activity against picornaviruses including coxsackie-, entero-, echo-, Polio-, and rhinoviruses, as well as exhibiting low cytotoxicity, so that they can be useful as an active ingredient of a pharmaceutical composition for the prevention or treatment of viral diseases including poliomyelitis, paralysis, acute hemorrhagic conjunctivitis, viral meningitis, hand-foot-and-mouth disease, vesicular disease, hepatitis A, myositis, myocarditis, pancreatitis, diabetes, epidemic myalgia, encephalitis, flu, herpangina, foot-and-mouth disease, asthma, chronic obstructive pulmonary disease, pneumonia, sinusitis or otitis media.

公开(公告)号：EP3559982A1

公开(公告)日：2019-10-30

申请号：EP17883386.9

申请日：2017-12-20

申请人： Illumina, Inc. ,  Illumina Cambridge Limited

发明人： TSAY, James ,  PRABHU, Anmiv ,  HEINER, David ,  LI, Edwin ,  RICHEZ, Alexandre ,  BEIERLE, John M. ,  SAMIEE, Kevan ,  MUNOZ, Kristina ,  MALEVANCHIK, Leonid ,  VINCENT, Ludovic ,  ZHAN, Naiqian ,  SHIEH, Peyton ,  YANG, Robert ,  SCHMITT, Samantha ,  PARK, Sang ,  BAILEY, Scott ,  RAMIREZ, Sean M. ,  AHN, Sunmin ,  UZZELL, Valerie ,  WEI, Wei ,  HUANG, Yuxiang ,  DILL, Tyler Jamison

IPC分类号： H01L21/3213 ,  H01L21/3105 ,  H01L21/56 ,  C12Q1/68 ,  C07C247/12

公开(公告)号：EP3357908A1

公开(公告)日：2018-08-08

申请号：EP16851632.6

申请日：2016-09-28

申请人： Fujifilm Finechemicals Co., Ltd.

发明人： KEMMOKU, Akira ,  HAGA, Yayoi ,  KAWAMOTO, Fumio

IPC分类号： C07D211/22 ,  C07B41/06 ,  C07B61/00 ,  C07C247/10 ,  C07H17/08

CPC分类号： C07B41/06 ,  B01J19/0093 ,  B01J2219/0086 ,  C07B61/00 ,  C07C247/10 ,  C07D211/22 ,  C07H17/08 ,  Y02P20/55

摘要： A production method for producing an aldehyde compound or a ketone compound by oxidizing a primary or secondary alcohol compound, wherein the alcohol compound has, in the molecule thereof, a group selected from an amino group, an azide group, a hydroxy group and a hydroxy group protected by a protecting group. The method comprises carrying out the reactions of a first step and a second step in succession, wherein the first step comprises collisionally mixing an alcohol compound, a dialkyl sulfoxide having 2 to 8 carbon atoms and an acid anhydride having 4 to 10 carbon atoms with one another in a continuous-flow-type flow reactor to react these components with one another, and the second step comprises collisionally mixing the liquid mixture that has been mixed in the first step with a trialkylamine having 3 to 10 carbon atoms in a continuous-flow-type flow reactor to react these components with each other.