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93 条记录 (耗时 0.035 秒)

    Glycolipid derivatives, process for production of the same, intermediates for synthesis thereof, and process for production of the intermediates
    9.
    发明公开
    Glycolipid derivatives, process for production of the same, intermediates for synthesis thereof, and process for production of the intermediates 有权
    Glykolipidderivate，其制造方法，中间体，用于中间体的它们的合成和制造方法

    公开(公告)号：EP2343306A1

    公开(公告)日：2011-07-13

    申请号：EP11160814.7

    申请日：2004-02-13

    申请人： Japan as represented by President of National Center of Neurology and Psychiatry Ministry of Health

    发明人： Annoura, Hirokazu ,  Murata, Kenji ,  Yamamura, Takashi

    IPC分类号： C07H15/04 ,  C07H15/26 ,  A61K31/7032 ,  A61P37/02 ,  C07C247/04 ,  C07C247/10 ,  C07D317/28

    CPC分类号： C07D317/28 ,  C07C247/04 ,  C07H15/04 ,  C07H15/26

    摘要： Novel glycolipid derivatives, where the substituent of the sphingosine base part is a short carbon chain alkyl group, substituted or unsubstituted cycloalkyl group, substituted or unsubstituted aryl group or substituted or unsubstituted aralkyl group and efficient synthetic methods for practical mass production of the same and intermediates useful for the synthesis of these compounds.
    Glycolipids having the formula (I):

    where R 3 indicates a substituted or unsubstituted C 1 to C 7 linear alkyl group, substituted or unsubstituted cycloalkyl group, substituted or unsubstituted aryl group, or substituted or unsubstituted aralkyl group and R 8 indicates a substituted or unsubstituted C 1 to C 35 alkyl group, substituted or unsubstituted aryl group or substituted or unsubstituted aralkyl group are chemically synthesized.

    摘要翻译： 新颖糖脂衍生物，其中所述鞘氨醇碱部分的取代基为短碳链的烷基，substituiertem奥德unsubstituiertem环烷基，substituiertem奥德unsubstituiertem芳基或substituiertem奥德unsubstituiertem芳烷基和实际大量生产相同和中间体的高效的合成方法 对于化合物论文的合成是有用的。 糖脂具有式（I）：其中，R 3表示substituiertem奥德unsubstituiertem的C 1至C 7的直链烷基，substituiertem奥德unsubstituiertem环烷基，substituiertem奥德unsubstituiertem芳基，或substituiertem奥德unsubstituiertem芳烷基和R 8表示一个substituiertem奥德 unsubstituiertem的C 1至C 35烷基，substituiertem奥德unsubstituiertem芳基或substituiertem奥德unsubstituiertem芳烷基是化学合成的。

    2-Amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic ester derivative
    10.
    发明公开
    2-Amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic ester derivative 有权
    2-氨基 - 二环[3.1.0]己烷-2,6-二羧酸酯衍生物

    公开(公告)号：EP2287147A2

    公开(公告)日：2011-02-23

    申请号：EP10181930.8

    申请日：2004-06-25

    申请人： Taisho Pharmaceutical Co., Ltd.

    发明人： Yasuhara, Akito ,  Sakagami, Kazunari ,  Ohta, Hiroshi ,  Nakazato, Atsuro

    IPC分类号： C07C229/50 ,  C07C235/06 ,  C07C247/04 ,  C07C323/61 ,  A61K31/365 ,  A61K31/357 ,  C07D307/88 ,  C07D317/34 ,  A61P25/00 ,  A61K31/225 ,  A61K31/5375 ,  A61K31/00

    CPC分类号： C07C229/50 ,  C07D307/88

    摘要： A drug effective for the treatment and prevention of psychiatric disorders such as schizophrenia, anxiety and related ailments thereof, depression, bipolar disorder and epilepsy. The drug antagonizes the action of group II metabotropic glutamate receptors and shows high activity in oral administraiton
    A 2-amino-bicyclo [3.1.0] hexane-2,6-dicarboxylic ester derivative represented by formula [I]

    [wherein R 1 and R 2 are identical or different, and each represents a hydrogen atom, a C 1-10 alkyl group or the like; X represents a hydrogen atom or a fluorine atom; Y represents -OCHR 3 R 4 or the like (wherein R 3 and R 4 are identical or different, and each represents a hydrogen atom, a C 1-10 alkyl group or the like; and n represents integer 1 or 2)], a pharmaceutically acceptable salt thereof or a hydrate thereof.

    摘要翻译： 一种有效治疗和预防精神障碍如精神分裂症，焦虑及其相关疾病，抑郁症，双相性精神障碍和癫痫的药物。 该药物拮抗II类代谢型谷氨酸受体的作用，并在口服给药中显示出高活性，其由式[I]表示的2-氨基 - 二环[3.1.0]己烷-2,6-二羧酸酯衍生物[其中R1和R2为 各自表示氢原子，C1-10烷基等; X代表氢原子或氟原子; Y表示-OCHR 3 R 4等（其中R 3和R 4相同或不同，并且各自表示氢原子，C 1-10烷基等;并且n表示整数1或2）]，其药学上可接受的盐或 其水合物。