公开(公告)号：EP3486253A1

公开(公告)日：2019-05-22

申请号：EP18212473.5

申请日：2011-11-04

申请人： The Board of Trustees of The Leland Stanford Junior University

发明人： DEISSEROTH, Karl ,  YIZHAR, Ofer ,  FENNO, Lief ,  HEGEMANN, Peter ,  PRIGGE, Matthias

IPC分类号： C07K14/405 ,  C12N15/62 ,  C12N5/10 ,  A01K67/027

摘要： Provided herein are compositions comprising light-activated chimeric proteins expressed on plasma membranes and methods of using the same to selectively depolarize excitatory or inhibitory neurons.

公开(公告)号：EP3090041B1

公开(公告)日：2019-04-24

申请号：EP14876326.1

申请日：2014-12-30

申请人： Synthetic Genomics, Inc.

发明人： AJJAWI, Imad ,  AQUI, Moena ,  CHAVEZ-TORRES, Carlos

IPC分类号： C12N1/12 ,  C12N15/82 ,  C12N15/79 ,  C07K14/405 ,  C12P7/64

公开(公告)号：EP3456732A1

公开(公告)日：2019-03-20

申请号：EP18197428.8

申请日：2012-10-02

申请人： Korea University Research and Business Foundation, Sejong Campus

发明人： PACK, Seung Pil ,  KI, Mi Ran

IPC分类号： C07K14/405 ,  C07K19/00 ,  C07K17/14 ,  A61K47/42 ,  A61K49/14

摘要： A peptide for synthesizing silica and use thereof are provided. The peptide for synthesizing silica can polymerize silica from a silica precursor in an aqueous solution having conditions of normal temperature, normal pressure and near-neutral weak base. The peptide for synthesizing silica can form a self-assembled structure during silica synthesis, and thus can be used as various biomaterials such as a silica-based protein immobilizer, a biosensor, and a drug delivery system.

公开(公告)号：EP2762488B1

公开(公告)日：2018-11-21

申请号：EP12835950.2

申请日：2012-10-02

申请人： Korea University Research and Business Foundation, Sejong Campus

发明人： PACK, Seung Pil ,  KI, Mi Ran

IPC分类号： C07K14/405 ,  C07K19/00 ,  C07K17/14 ,  A61K47/42 ,  A61K49/14

CPC分类号： C12N9/1205 ,  A61K38/45 ,  A61K49/00 ,  C07K14/00 ,  C07K14/405 ,  C07K17/14 ,  C07K2319/735 ,  C12Y207/01

摘要： A peptide for synthesizing silica and use thereof are provided. The peptide for synthesizing silica can polymerize silica from a silica precursor in an aqueous solution having conditions of normal temperature, normal pressure and near-neutral weak base. The peptide for synthesizing silica can form a self-assembled structure during silica synthesis, and thus can be used as various biomaterials such as a silica-based protein immobilizer, a biosensor, and a drug delivery system.

公开(公告)号：EP3401388A1

公开(公告)日：2018-11-14

申请号：EP18178313.5

申请日：2013-12-06

申请人： Synthetic Genomics, Inc.

发明人： Bailey, Shaun ,  McCarren, Jay ,  Lieberman, Soyan Leung ,  Meuser, Jonathan E. ,  Romano, Anna E. ,  Yee, Daniel ,  Soriaga, Leah ,  Brown, Robert C. ,  Weissman, Joseph C. ,  Prince, Roger C. ,  Nielsen, Robert D. ,  Schwartz, Ariel S.

IPC分类号： C12N1/12 ,  C12N1/36 ,  C12N15/01 ,  C12N15/11 ,  C12N15/82 ,  C12N15/87 ,  C07K14/415 ,  C07K14/405

CPC分类号： C12N15/825 ,  C07K14/405 ,  C07K14/415 ,  C12N1/12 ,  C12N1/36 ,  C12N15/01 ,  C12N15/8269

摘要： Mutant photosynthetic microorganisms having reduced chlorophyll and increased photosynthetic efficiency are provided. The mutants have a locked in high light-acclimated phenotype, in which many of the photosynthetic parameters characteristic of high light acclimated wild type cells are found in the LIHLA mutants when acclimated to low light, such as reduced chlorophyll, reduced NPQ, higher qP, higher Ek, higher P max per unit chlorophyll with little to no reduction in P max per cell, and higher rates of electron transport through photosystem II over a wide range of light intensities. Provided herein are constructs for attenuating or disrupting genes are provided for generating mutants having the LIHLA phenotype. Also provided are methods of culturing LIHLA mutants for the production of biomass or other products.

公开(公告)号：EP3214094A1

公开(公告)日：2017-09-06

申请号：EP17165633.3

申请日：2012-11-12

申请人： Massachusetts Institute of Technology ,  The Governors of the University of Alberta

发明人： KLAPOETKE, Nathan ,  CHOW, Brian, Yichiun ,  BOYDEN, Edward ,  WONG, Gane, Ka-Shu ,  CHO, Yongku Peter

IPC分类号： C07K14/405 ,  A61K38/16 ,  C12Q1/02 ,  G01N33/68 ,  A61K38/00 ,  A61N5/06 ,  A61K41/00 ,  C12N13/00 ,  G01N33/487 ,  G01N33/50

摘要： The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of light-activated ion channels.

摘要翻译： 本发明在一些方面涉及用于改变细胞活性和功能以及光激活离子通道的引入和使用的组合物和方法。

公开(公告)号：EP3090041A4

公开(公告)日：2017-06-07

申请号：EP14876326

申请日：2014-12-30

申请人： SYNTHETIC GENOMICS INC

发明人： AJJAWI IMAD ,  AQUI MOENA ,  CHAVEZ-TORRES CARLOS

IPC分类号： C12N1/12 ,  C07K14/405 ,  C12N15/79 ,  C12N15/82 ,  C12P7/64

CPC分类号： C07K14/405 ,  C12N15/79 ,  C12N15/8247 ,  C12N15/8261 ,  C12P7/6463 ,  Y02A40/146

摘要： The disclosure generally relates to methods and materials for modulating cell productivity. In particular, the present disclosure provides polynucleotides and polypeptides that when overexpressed in microorganisms result in increased in productivity, such as increased biomass productivity. Also disclosed are methods of using the polynucleotides and polypeptides to modulate or increase productivity of host cells such as, for example, algal or heterokont cells. Genetically engineered host cells, such as algal and heterokont cells having increased biomass productivity and bioproducts derived from such host cells are also disclosed.

摘要翻译： 本公开总体涉及用于调节细胞生产力的方法和材料。 特别地，本公开提供了当在微生物中过表达时导致生产力增加，例如生物量增加的多核苷酸和多肽。 还公开了使用多核苷酸和多肽来调节或增加宿主细胞例如藻类或异形细胞的生产力的方法。 还公开了基因工程宿主细胞，例如具有增加的生物生产力的藻类和异质细胞以及源自这种宿主细胞的生物产品。

公开(公告)号：EP2817409A4

公开(公告)日：2016-05-11

申请号：EP13754200

申请日：2013-02-25

申请人： SAPPHIRE ENERGY INC

发明人： YOHN CHRISTOPHER

IPC分类号： C12N15/29 ,  A01H5/00 ,  C07K14/405 ,  C12N15/82 ,  C12P7/64 ,  C12R1/89

CPC分类号： C12N15/8247 ,  C07K14/405 ,  C12N9/00 ,  C12P7/6463

公开(公告)号：EP2673291A1

公开(公告)日：2013-12-18

申请号：EP12703874.3

申请日：2012-02-10

申请人： University of East Anglia ,  University of Washington through its Center for Commercialization

发明人： MOCK, Thomas ,  HIPKIN, Rachel Elizabeth

IPC分类号： C07K14/405

CPC分类号： C07K14/405 ,  C07K14/415 ,  C12N15/8261 ,  Y02A40/146

摘要： The present invention relates to a polypeptide (BIG1) and variants thereof capable of enhancing the rate of cell-division of a microorganism or plant cell, as well as nucleic acid molecules encoding said polypeptides, vectors comprising said nucleic acid molecules and host cells transformed or transfected with said vectors and expressing said polypeptides. The BIG1 polypeptide which has been identified in the marine centric diatom Thalassiosira pseudonana, variants thereof and nucleic acids encoding these may be used in methods of enhancing the rate of cell-division of microorganisms, plant cells or plants which produce useful sub stances or exhibit useful properties, to increase the yield thereof.

公开(公告)号：EP2412796A4

公开(公告)日：2013-02-27

申请号：EP10755519

申请日：2010-03-18

申请人： PROTEUS SA

发明人： LAGOS GONZALEZ MARCELO SANTIAGO

IPC分类号： C12N1/12 ,  C07K14/405

CPC分类号： C12N1/12