利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

1105 条记录 (耗时 0.026 秒)

    METHODS FOR SELECTIVELY TREATING COX-2 MEDIATED DISORDERS BY ADMINISTERING GAMMA-TOCOPHEROL
    75.
    发明公开
    METHODS FOR SELECTIVELY TREATING COX-2 MEDIATED DISORDERS BY ADMINISTERING GAMMA-TOCOPHEROL 审中-公开
    PROCESS FOR通过给予γ-生育酚COX-2介导的病症选择性治疗

    公开(公告)号：EP1912654A2

    公开(公告)日：2008-04-23

    申请号：EP06735623.8

    申请日：2006-02-22

    申请人： Merial Limited

    发明人： HANSON, Peter

    IPC分类号： A61K31/60

    CPC分类号： A61K31/355 ,  A61K31/335 ,  A61K31/4745 ,  A61K31/7008 ,  A61K31/726 ,  A61K31/727 ,  A61K31/737 ,  A61K2300/00

    摘要： The present invention is based upon the novel observation of the COX-II-specific inhibitory activity of gamma-tocopherol and that by combining gamma-tocopherol with precursors of connective tissue constituents, injured or degenerated connective tissue, especially of articulated joints of animal patients, may be repaired. The method of the invention for treating a inflammatory disorder of a joint comprises administering to the mammal a pharmaceutical composition comprising an amount of gamma-tocopherol effective in selectively inhibiting cyclooxygenase-2 and at least one compound that elevates the production of a component of connective tissue in an amount effective for the promotion of connective tissue formation. The invention also provides pharmaceutical or veterinary compositions comprising a tocopherol preparation having at least 50% w/w gamma- tocopherol or a derivative thereof and in an amount effective for selectively inhibiting cyclooxygenase-2 in the recipient mammal and at least one compound that elevates the production of a component of connective tissue.

    ORGANIC NITRIC OXIDE ENHANCING SALTS OF NONSTEROIDAL ANTIINFLAMMATORY COMPOUNDS, COMPOSITIONS AND METHODS OF USE
    76.
    发明公开
    ORGANIC NITRIC OXIDE ENHANCING SALTS OF NONSTEROIDAL ANTIINFLAMMATORY COMPOUNDS, COMPOSITIONS AND METHODS OF USE 审中-公开
    有机氮氧化物增强从非甾体抗炎化合物和组合物及其使用方法盐类

    公开(公告)号：EP1883614A2

    公开(公告)日：2008-02-06

    申请号：EP06770830.5

    申请日：2006-05-23

    申请人： Nitromed, Inc.

    发明人： GARVEY, David, S.

    IPC分类号： C07C7/10 ,  B32B15/00 ,  A61K31/60

    CPC分类号： C07C229/42 ,  C07C57/58 ,  C07C59/64 ,  C07C59/68 ,  C07C59/84 ,  C07C59/86 ,  C07C59/88 ,  C07C313/36 ,  C07D209/12 ,  C07D263/32 ,  C07D277/24 ,  C07D279/12 ,  C07D333/22 ,  C07D471/04 ,  C07D498/04

    摘要： The invention describes novel organic nitric oxide enhancing salts of nonsteroidal antiinflammatory drugs (NSAIDs) and novel compositions comprising at least one organic nitric oxide enhancing salt of an NSAID, and, optionally, at least one nitric oxide enhancing compound and/or at least one therapeutic agent. The invention also provides novel compositions and kits comprising at least one organic nitric oxide enhancing salt of an NSAID, and, optionally, at least one nitric oxide enhancing compound and/or at least one therapeutic agent. The invention also provides methods for (a) treating inflammation, pain and fever; (b) treating gastrointestinal disorders; (c) facilitating wound healing; (d) treating gastrointestinal, renal and/or respiratory toxicities resulting from the use of nonsteroidal antiinflammatory compounds; (e) treating inflammatory disease states and/or disorders; (f) treating ophthalmic disorders; (h) treating peripheral vascular diseases; (i) treating diseases resulting from oxidative stress; (j) treating endothelial dysfunctions; and (k) treating diseases caused by endothelial dysfunctions. The organic nitric oxide enhancing compounds that form salts with the NSAIDs are organic nitrates, organic nitrites, nitrosothiols, thionitrites, thionitrates, NONOates, heterocyclic nitric oxide donors and/or nitroxides. The heterocyclic nitric oxide donors are furoxans, sydnonimines, oxatriazole-5-ones and/or oxatriazole-5- imines.