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    Altered fibronectin-binding protein of staphylococcus aureus
    75.
    发明公开
    Altered fibronectin-binding protein of staphylococcus aureus 审中-公开
    Stapylococcus黄色葡萄球菌的改性纤连蛋白结合蛋白

    公开(公告)号：EP2301957A3

    公开(公告)日：2011-05-18

    申请号：EP10182756.6

    申请日：2005-05-17

    申请人： Wyeth LLC

    发明人： Matsuka, Yury, Vladimirovich ,  Baker, Steven, Morris ,  Aanderson, Elisabeth, Teremy

    IPC分类号： C07K14/31

    CPC分类号： C07K14/78 ,  A61K39/00 ,  C07K14/31

    摘要： An isolated, altered fibronectin-binding protein (Fnb) of S. aureus having at least one mutation in an amino acid selected from residues corresponding to GIn103, GIn105, Lys157, Lys503, Lys620, Lys702, Lys762, Gln783 and Gln830 of FnbA of S. aureus strain ATCC49525 is described. Replacement of these reactive residues within the fibronectin-binding protein renders this protein less capable than wild-type Fnb of covalently cross-linking with fibronectin and fibrin. The altered fibronectinbinding protein effectively interferes with adhesion of S. aureus to fibronectin and fibrin, and therefore, an immunogenic composition comprising such altered Fnb exhibits improved immunogenic properties and is safer to use.

    Use of Panton-Valentine Leukocidin for treating and preventing staphylococcus infections
    76.
    发明公开
    Use of Panton-Valentine Leukocidin for treating and preventing staphylococcus infections 审中-公开
    使用潘顿 - 瓦伦丁杀白细胞素对葡萄球菌感染的治疗和预防

    公开(公告)号：EP2289938A2

    公开(公告)日：2011-03-02

    申请号：EP10180402.9

    申请日：2006-06-13

    申请人： GlaxoSmithKline Biologicals S.A.

    发明人： Taylor, Kimberly Louise ,  Fattom, Ali Ibrahim

    IPC分类号： C07K16/12 ,  C07K14/31 ,  A61K39/395 ,  A61K39/085 ,  A61P31/04

    CPC分类号： A61K39/085 ,  A61K2039/505 ,  C07K14/31 ,  C07K16/1271 ,  C07K2317/76

    摘要： The present invention relates to compositions and methods for treating Staphylococcus aureus ( S. aureus ) infections. In particular, the present invention provides vaccines comprising a Panton-Valentine Leukocidin (PVL) antigen, antibodies which bind a PVL antigen and compositions containing the same, methods of making such compositions and methods for treating S . aureus infections, including those that are community acquired methicillin-resistant infections. The present invention also provides PVL antibodies, including PVL antibodies specific for a single PVL subunit, and PVL antigens, including conjugated and mutated PVL antigens.

    摘要翻译： 本发明涉及组合物和方法用于治疗金黄色葡萄球菌（金黄色葡萄球菌）感染。 特别地，本发明提供了疫苗，其包括潘顿-Valentine杀白细胞素（PVL）抗原，其结合一个PVL抗原和组合物含有相同，使得搜索组合物和方法用于治疗S的方法的抗体 金黄色葡萄球菌感染，包括thosethat是社区获得性耐甲氧西林感染。 本发明因此提供PVL抗体，包括特异于单个PVL亚基PVL抗体，和PVL抗原，包括共轭和突变PVL抗原。