-
81.发明授权PYROGLUTAMATE SALTS AND THEIR USE IN THE OPTICAL RESOLUTION OF INTERMEDIATES FOR THE SYNTHESIS OF DEXTROCETIRIZINE AND LEVOCETIRIZINE 有权PYROGLUTAMATSALZE和它们在中间体的光学分离FOR DEXTROCETIRIZIN和左西替利的合成
公开(公告)号：EP1858866B1
公开(公告)日：2009-06-10
申请号：EP06707220.7
申请日：2006-02-23
申请人： UCB FARCHIM, S.A.
发明人： PALACIO, Magali , ATES, Célal
IPC分类号： C07D295/088 , C07D207/28
CPC分类号： C07D295/088 , C07D207/28
摘要： The present invention relates to (S)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]- ethoxyacetamide - (S)-pyrrolidone-5-carboxylic acid salt; (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide - (S)-pyrrolidone-5-carboxylic acid salt; (S)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide - (R)-pyrrolidone-5-carboxylic acid salt; or (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxycetamide - (R)-pyrrolidone-5-carboxylic salt. The present invention relates also to a process for preparing (S)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide (I) and (R)-2-[4-(4-chlorobenzhydryl) piperazin-1-yl]-ethoxyacetamide (II) by chemical resolution of a mixture. These compounds are respectively intermediates for the synthesis of dextrocetirizine and levocetirizine.
-
82.发明授权OXOPYRROLIDINE COMPOUNDS, PREPARATION OF SAID COMPOUNDS AND THEIR USE IN THE MANUFACTURING OF LEVETIRACETAM AND ANALOGUES 有权氧吡咯烷化合物的方法，生产这些化合物及其用途用于生产左乙拉西坦和模拟
公开(公告)号：EP1419144B1
公开(公告)日：2008-10-08
申请号：EP02764832.8
申请日：2002-08-05
申请人： UCB Pharma S.A.
IPC分类号： C07D207/26
CPC分类号： C07D207/27 , C07D207/26
摘要： The present invention relates to an improved process for the preparation of (S)-(-)-α-ethyl-2-oxo-1-pyrrolidine acetamide and analogues thereof. The invention also relates to compounds of the general formula (6) wherein R1 is methyl or ethyl ; and R2 is C2'-C4191 alkyl, C2191-C4191 alkenyl or C2191-C41 91 alkynyl, optionally substituted by one or more halogen, and their preparation processes.
-
83.发明授权Methods for the identification of agents for the treatment of seizures, neurological diseases, endocrinopathies and hormonal diseases 有权标识剂的癫痫发作，神经系统疾病，内分泌病和激素的疾病的治疗方法
公开(公告)号：EP1426768B1
公开(公告)日：2008-09-17
申请号：EP03027613.3
申请日：2003-12-02
申请人： UCB Pharma S.A.
发明人： Lynch, Berkley , Nocka, Karl , Fuks, Bruno
CPC分类号： G01N33/6896 , G01N2500/02
-
84.发明授权DIARYLMETHYLPIPERAZINES AS PROPHYLACTIC OR THERAPEUTIC AGENTS FOR VIRAL MYOCARDITIS 有权DIARYLMETHYLPIPERAZINES THAN或预防性治疗剂对病毒性心肌炎
公开(公告)号：EP1521581B1
公开(公告)日：2008-02-20
申请号：EP03762520.9
申请日：2003-06-26
申请人： UCB FARCHIM S.A.
发明人： MATSUMORI, Akira , KOUZAN, Serge
IPC分类号： A61K31/495 , A61P31/12
CPC分类号： A61K31/495 , Y02A50/463 , Y02A50/465
摘要： To provide a therapeutic agent for viral myocarditis and viral myocarditis-related viral diseases by treating the occurrence of cell damage in various organs regardless of the type of virus. A therapeutic agent for viral myocarditis and viral myocarditis-related viral diseases is provided that has as an active ingredient 2-[4-(dipehnylmethyl)-1-piperazinyl]-acetic acid, amide derivative, individual optical isomer or pharmaceutically acceptable salt thereof.
-
85.发明授权2,6-QUINOLINYL AND 2,6-NAPHTHYL DERIVATIVES AND THEIR USE IN THE TREATMENT OF VLA-4 DEPENDENT DISEASES 有权2,6-喹啉基和2,6-萘衍生物及其用途FOR VLA-4相关的疾病治疗
公开(公告)号：EP1501801B1
公开(公告)日：2008-01-23
申请号：EP03747411.1
申请日：2003-04-15
申请人： UCB Pharma, S.A.
发明人： LASSOIE, Marie-Agnes , KNERR, Laurent , DEMAUDE, Thierry , DE LAVELEYE-DEFAIS, Françoise , KOGEJ, Thierry , ROUTIER, Sylvain , GUILLAUMET, Gerald , QUERE, Luc
IPC分类号： C07D215/14 , A61K31/47 , C07D215/22 , C07D401/06 , C07D401/12 , C07D215/36 , C07C233/87 , A61P37/08 , A61P19/02 , A61P29/00 , C07C205/49 , C07C237/36 , C07C43/205 , C07C309/65 , C07C229/40
CPC分类号： C07C309/65 , C07D215/227
摘要： The present invention concerns 2,6-quinolinyl and 2,6-naphthyl derivatives of formula (I), processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals for the treatment of VLA-4 dependent inflammatory diseases such as for example asthma, allergic rhinitis, sinusitis, conjunctivitis, food allergy, psoriasis, urticaria, pruritus, eczema, rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis and atherosclerosis. Formula (I): wherein X is N or CH.
-
86.发明公开Methods for the identification of agents for the treatment of seizures, neurological diseases, endocrinopathies and hormonal diseases 有权标识剂的癫痫发作，神经系统疾病，内分泌病和激素的疾病的治疗方法
公开(公告)号：EP1426768A3
公开(公告)日：2006-08-30
申请号：EP03027613.3
申请日：2003-12-02
申请人： UCB S.A.
发明人： Lynch, Berkley , Nocka, Karl , Fuks, Bruno
CPC分类号： G01N33/6896 , G01N2500/02
摘要： The present invention is drawn to methods of characterization of the properties and functions of SV2 proteins. The invention further includes methods of identifying compounds or agents which modulate the activity of SV2 proteins. Included in these methods is the identification of compounds or agents which modulate the binding of levetiracetam SV2 proteins, including SV2A.
-
公开(公告)号：EP1667967A1
公开(公告)日：2006-06-14
申请号：EP04765134.4
申请日：2004-09-13
申请人： UCB, S.A.
IPC分类号： C07D207/26
CPC分类号： C07D207/277 , C07D207/267
摘要： The present invention relates to a new process for preparing 2-oxo- I -pyrrolidine derivatives of general formula (I) wherein the substituents are as defined in the specification.
-
">
公开(公告)号：EP1447399B1
公开(公告)日：2006-05-03
申请号：EP04007733.1
申请日：2001-02-21
申请人： UCB, S.A.
发明人： Differding, Edmond , Kenda, Benoît , Lallemand, Bénédicte , Matagne, Alain , Michel, Philippe , Pasau, Patrick , Talaga, Patrice
IPC分类号： C07D207/27 , A61K31/4015 , A61P25/08
CPC分类号： C07D207/26 , A61K31/4015 , C07C237/12 , C07D207/27 , C07D207/273 , C07D207/277 , C07D307/33 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/12 , C07D409/04 , C07D413/04 , C07D417/04 , C07D495/04
-
89.发明公开INDOLONE-ACETAMIDE DERIVATIVES, PROCESSES FOR PREPARING THEM AND THEIR USES 有权INDOLONACETAMIDDERIVATE，方法及其及其用途
公开(公告)号：EP1620399A1
公开(公告)日：2006-02-01
申请号：EP04720863.2
申请日：2004-03-16
申请人： UCB, S.A.
IPC分类号： C07D209/34 , A61K31/405 , C07D209/54 , C07D209/08 , A61P25/08
CPC分类号： C07D495/10 , C07D209/08 , C07D209/34
摘要： The present invention relates to indolone-acetamide derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as for the treatment of epilepsy, epileptogenesis, seizure disorders and convulsion.
-
90.发明公开A pyrrolidineacetamide derivative alone or in combination for treatment of CNS disorders 审中-公开吡咯烷基乙酰胺衍生物，等位基因组合，zur Behandlung von ZNS-Störungen
公开(公告)号：EP1600169A2
公开(公告)日：2005-11-30
申请号：EP05019212.9
申请日：2000-11-27
申请人： UCB, S.A.
IPC分类号： A61K45/06 , A61K31/4015 , A61K31/19 , A61P25/06
CPC分类号： A61K45/06 , A61K31/19 , A61K31/40 , A61K31/4015 , A61K31/515 , A61K31/55 , A61K31/56 , Y10S514/922 , A61K2300/00
摘要： A use of (S)-(-)-α-ethyl-2-oxo-l-pyrrolidineacetamide for the manufacture of a medicament for treatment of particular diseases and new pharmaceutical compositions comprising (S)-(-]-α-ethyl-2-oxo-1-pyrrolidineacetamide.
摘要翻译： （S） - （ - ） - - - - - 乙基-2-氧代-1-吡咯烷乙酰胺用于制备用于治疗特定疾病的药物的用途和包含（S） - （ - ） - 2-氧代-1-吡咯烷乙酰胺。
-
-
-
-
-
-
-
-
-
搜索结果
148 条记录 (耗时 0.019 秒)
