摘要:
A heterocyclic compound represented by the general formula (I) (I) {wherein X represents nitrogen or CH; R1 represents CHnF3-n (n is 1 or 2), hydroxylated C1-6 alkyl, or NHR6 [R6 represents hydrogen or COR (R represents hydrogen, C1-6 alkyl, or C1-6 alkoxy)]; R2 represents morpholino (optionally substituted by one to four C1-6 alkyls), thiomorpholino, piperidino, pyrrolidinyl (optionally substituted by hydroxylated C1-6 alkyl), oxazolidinyl (optionally substituted by one or two C1-6 alkyls), or tetrahydro-1, 4-thiazin-1-oxo-4-yl; R3 and R4 each represents hydrogen or C1-6 alkyl; and R5 represents hydrogen, amino, or hydroxy} or a pharmaceutically acceptable salt thereof; and an antitumor agent containing the heterocyclic compound as the active ingredient.
摘要:
The invention relates to pearlescent pigments comprising a metal oxide-containing, lamellar substrate and a protective layer, the metal oxide having a refractive index of more than 1.8. The protective layer is composed of an organic-chemical surface-modified SiO2 layer, the organic-chemical surface modification being applied to the SiO2 layer. The invention further relates to a method for producing said pearlescent pigments and the use thereof.
摘要:
The present invention relates to the diagnosis and treatment of B-cell disorders such as multiple myeloma (MM). In particular, the present invention relates to the treatment of B-cell disorders using ligands which bind to free lambda light chains expressed on the surface of lymphoid cancer cells.
摘要:
The invention relates to a composition comprising isolated, culture-expanded human mesenchymal stem cells and a bioactive factor effective to induce differentiation of such cells into a chondrogenic mesenchymal lineage.
摘要:
The invention relates to electrically conductive pigments having a ferromagnetic core and at least one electrically conductive coating. This electrically conductive coating is or comprises a metal or a metal alloy or is or comprises electrically conductive polymers or plastics that contain electrically conductive polymers. The invention also relates to a method for producing the electrically conductive pigments as well as to the use of these electrically conductive pigments.
摘要:
The present invention discloses a method of broadband access device for controlling a DHCP relay user, which method comprises modifying protocol fields in all of DHCP messages interacted between a DHCP relay and a DHCP client and a DHCP server during initiation phase of the DHCP interaction at Application Layer of TCP/IP protocol so that all of the DHCP messages interacted between the client and the server can pass through the DHCP relay. The present invention can easily control and manage the interaction between the DHCP client and the external DHCP server, vary the network parameters of the DHCP user and detecting the DHCP user online and so on according to the requirements of the user management strategy. Furthermore, the present invention only needs to process Application Layer of TCP/IP protocol to achieve the predetermined purpose of control/ management.
摘要:
The present invention relates to a lip package for accommodating a liquid cosmetic, and more particularly, to a lip package for dispensing a desired amount of a flowable liquid cosmetic such as lip gloss, wherein upon pressing a button formed on the exterior of the container, an actuating member disposed within the container raises a piston to dispense a predetermined amount of the liquid cosmetic contained in the container, thereby improving convenience of use and enabling the use thereof with one hand due to the button type structure.
摘要:
Free-flowing unsaturated fatty acid calcium salts with a fatty acid content consisting essentially of (a) about 40 to about 95 wt% unsaturated C16-C22 fatty acids; (b) about 5 to about 60 wt% saturated C14-C22 fatty acids; and (c) no more than about 6 wt% moisture, insolubles and unsaponifiables; with no more than about 20 wt% in the form of glycerides; wherein about 40 to about 65 wt% of total product weight is of trans fatty acids and one or more fatty acids selected from C18:2 and C18:3 fatty acids and C20-C22 omega-3 and omega-6 fatty acids. Products with about 10 to about 65 wt% of total product weight of CLA's and one or more fatty acids selected from non-conjugated C18:2 and C18:3 fatty acids and C20-C22 omega-3 and omega-6 fatty acids are also disclosed.
摘要:
An antibiotic product is comprised of at least three dosages forms, each of which has a different release profile, with the Cmax for the antibiotic product being reached in less than about twelve hours. In one embodiment, there is an immediate release dosage form, as well as two or more sustained release dosage forms, with each of the dosage forms having a different release profile, wherein each reaches a Cmax at different times.
摘要:
Disclosed are new compounds that increase the absorption of pharmaceutical agents across mucous membranes. These absorption enhancers allow higher bioavailability of administered drugs. The enhancers advantageously have low or no cytotoxicity.