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公开(公告)号：EP1165590A4
公开(公告)日：2003-02-26
申请号：EP00916354
申请日：2000-03-16
IPC分类号： G01N33/53 , A61K35/36 , A61K38/00 , A61K48/00 , A61P17/02 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P29/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12Q1/02 , C12Q1/68 , G01N33/566 , G01N33/68 , C07H21/04 , C07K14/00 , C07K16/00 , C12N15/00 , C12N15/63 , C12N15/85 , C12N15/86
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公开(公告)号：EP1282644A1
公开(公告)日：2003-02-12
申请号：EP01923180.2
申请日：2001-04-05
发明人： SHI, Yanggu , RUBEN, Steven, M.
IPC分类号： C07K14/705 , A01K67/027 , C12N15/12
CPC分类号： C07K14/705 , A61K38/00 , A61K48/00
摘要： The present invention relates to novel human TM4SF polypeptides and isolated nucleic acids containing the coding regions of the genes encoding such polypeptides. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human TM4SF polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human TM4SF polypeptides.
摘要翻译： 本发明涉及新的人TM4SF多肽和含有编码这些多肽的基因的编码区的分离的核酸。 还提供了用于生产人TM4SF多肽的载体，宿主细胞，抗体和重组方法。 本发明进一步涉及用于诊断和治疗与这些新型人TM4SF多肽有关的病症的诊断和治疗方法。
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公开(公告)号：EP1276756A1
公开(公告)日：2003-01-22
申请号：EP01944114.6
申请日：2001-04-12
IPC分类号： C07H21/04
CPC分类号： A61K38/4846 , A01K2217/05 , A61K9/0019 , A61K38/21 , A61K38/212 , A61K38/38 , A61K47/42 , A61K47/65 , A61K48/00 , A61K2039/54 , C07K14/56 , C07K14/61 , C07K14/62 , C07K14/65 , C07K14/705 , C07K14/7151 , C07K14/76 , C07K14/765 , C07K2319/00 , C07K2319/21 , C07K2319/31 , C07K2319/50 , C07K2319/75 , C12N9/96 , C12N15/62 , Y02A50/386 , Y02A50/401 , Y02A50/412
摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.
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公开(公告)号：EP1165587A4
公开(公告)日：2003-01-15
申请号：EP00913810
申请日：2000-03-09
IPC分类号： G01N33/53 , A61K31/7088 , A61K38/00 , A61K48/00 , A61P9/00 , A61P17/00 , A61P25/00 , A61P31/00 , A61P35/00 , A61P43/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12Q1/02 , C12Q1/68 , G01N33/566 , C12N15/12 , A61K38/17 , A61K39/395
CPC分类号： C07K14/47
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公开(公告)号：EP1159286A4
公开(公告)日：2003-01-15
申请号：EP00916071
申请日：2000-03-03
发明人： GENTZ REINER L , NI JIAN , EBNER REINHARD , YU GUO-LIANG , RUBEN STEVEN M , FENG PING
IPC分类号： C12N15/09 , A61K35/76 , A61K38/00 , A61K39/395 , A61K48/00 , A61P1/00 , A61P1/04 , A61P1/16 , A61P3/10 , A61P5/14 , A61P7/06 , A61P9/00 , A61P9/02 , A61P9/04 , A61P9/06 , A61P9/08 , A61P9/10 , A61P9/12 , A61P9/14 , A61P13/12 , A61P19/08 , A61P19/10 , A61P25/00 , A61P25/16 , A61P25/28 , A61P27/02 , A61P29/00 , A61P31/04 , A61P31/12 , A61P31/18 , A61P35/00 , A61P35/02 , A61P37/02 , A61P37/06 , A61P43/00 , C07K14/715 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02 , C12R1/91 , C07K14/00 , C12N5/00 , C12N5/06 , C12N15/63 , C12P21/00 , C12Q1/68
CPC分类号： C07K14/7151 , A61K38/00
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公开(公告)号：EP1261742A2
公开(公告)日：2002-12-04
申请号：EP01916069.6
申请日：2001-01-17
摘要： The present invention relates to novel immune/hematopoietic-related polynucleotides and the polypeptides encoded by these polynucleotides herein collectively known as 'immune/hematopoietic antigens', and the use of such immune/hematopoietic antigens for detecting immune/hematopoietic-related diseases and/or disorders, particularly the presence of cancer and cancer metastases of cells of hematopoietic origin. More specifically, isolated immune/hematopoietic associated nucleic acid molecules are provided encoding novel immune/hematopoietic associated polypeptides. Novel immune/hematopoietic polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human immune/hematopoietic associated polynucleotides and/or polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to the immune system or cells and tissues associated with hematopoiesis, including cancers of cells of hematopoietic origin, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting the production and function of the polypeptides of the present invention.
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公开(公告)号：EP1261703A1
公开(公告)日：2002-12-04
申请号：EP01912655.6
申请日：2001-01-17
CPC分类号： Y02A50/475
摘要： The present invention relates to novel musculoskeletal system related polynucleotides and the polypeptides encoded by these polynucleotides herein collectively known as ' musculoskeletal system antigens', and the use of such musculoskeletal system antigens for detecting disorders of the musculoskeletal system, particularly the presence of cancer and cancer metastases. More specifically, isolated musculoskeletal system associated nucleic acid molecules are provided encoding novel musculoskeletal system associated polypeptides. Novel musculoskeletal system polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human musculoskeletal system associated polynucleotides and/or polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to the musculoskeletal system, including cancer of musculoskeletal tissues, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting the production and function of the polypeptides of the present invention.
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公开(公告)号：EP1261618A2
公开(公告)日：2002-12-04
申请号：EP01912657.2
申请日：2001-01-17
CPC分类号： Y02A50/475
摘要： The present invention relates to novel kidney related polynucleotides and the polypeptides encoded by these polynucleotides herein collectively known as 'kikdney antigens', and the use of such kidney antigens for detecting disorders of the kidney, particularly the presence of kidney cancer and kidney cancer metastases. More specifically, isolated kidney associated nucleic acid molecules are provided encoding novel kidney associated polypeptides. Novel kidney polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human kidney associated polynucleotides and/or polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to the kidney, including kidney cancer, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting the production and function of the polypeptides of the present invention.
摘要翻译： 本发明涉及新的肾相关多核苷酸和由本文统称为“kikdney抗原”的这些多核苷酸编码的多肽，以及此类肾抗原用于检测肾病，特别是肾癌和肾癌转移的存在的用途。 更具体而言，提供了编码新型肾相关多肽的分离的肾相关核酸分子。 提供了新的肾多肽和结合这些多肽的抗体。 还提供了载体，宿主细胞以及用于产生人肾相关多核苷酸和/或多肽的重组和合成方法。 本发明进一步涉及用于诊断，治疗，预防和/或预测与肾相关的病症（包括肾癌）的诊断和治疗方法，以及用于治疗此类病症的治疗方法。 本发明进一步涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。 本发明还涉及用于抑制本发明多肽的产生和功能的方法和/或组合物。
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公开(公告)号：EP1261380A1
公开(公告)日：2002-12-04
申请号：EP01912649.9
申请日：2001-01-17
CPC分类号： Y02A50/475
摘要： The present invention relates to novel proteins. More specifically, isolated nucleic acid molecules are provided encoding novel polypeptides. Novel polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human polynucleotides and/or polypeptides and antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to these novel polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
摘要翻译： 本发明涉及新蛋白质。 更具体而言，提供了编码新多肽的分离的核酸分子。 提供了与这些多肽结合的新多肽和抗体。 还提供了载体，宿主细胞以及用于生产人多核苷酸和/或多肽和抗体的重组和合成方法。 本发明进一步涉及用于诊断，治疗，预防和/或预测与这些新多肽有关的病症的诊断和治疗方法。 本发明进一步涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。 本发明进一步涉及用于抑制或增强本发明多肽的产生和功能的方法和/或组合物。
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