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101 条记录 (耗时 0.022 秒)

    Design of bioactive peptides based on immunoglobulin structure
    88.
    发明公开
    Design of bioactive peptides based on immunoglobulin structure 失效
    设计von bioaktiven Peptiden auf der Basis von immunglobulin Strukturen

    公开(公告)号：EP1310557A1

    公开(公告)日：2003-05-14

    申请号：EP02080338.3

    申请日：1991-09-13

    申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA ,  THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY ,  COLORADO STATE UNIVERSITY

    发明人： Weiner, David ,  Williams, Robert M. ,  Kieber-Emmons, Thomas ,  Williams, Wiliam ,  Greene, Mark I.

    IPC分类号： C12N15/12 ,  C12N15/13 ,  C07K16/00 ,  C07K14/705

    CPC分类号： C07K16/1063 ,  A61K39/00 ,  C07K14/005 ,  C07K14/7051 ,  C07K14/70514 ,  C07K14/70539 ,  C07K16/10 ,  C12N2720/12022 ,  C12N2740/16122

    摘要： The present invention relates to a method for producing peptides which have biological activity comprising: (i) identifying a region of a protein of interest which is homologous to a member of the immunoglobulin superfamily of molecules; (ii) synthesizing a peptide which comprises amino acid sequence found in the region of homology; and (iii) modifying the synthetic peptide such that it assumes a three-dimensional conformation which is biologically active. The invention is based, in part, on the discovery that a cyclic peptide comprising amino acid sequences of a CDR derived from an antibody directed toward a viral receptor molecule can be used to effectively inhibit the binding of virus to its receptor. The invention is also based in part on the discovery that a cyclic peptide corresponding to a portion of human immunodeficiency virus (HIV) gp120 that is homologous to immunoglobulins may be used to generate an anti-HIV immune response.

    摘要翻译： 本发明涉及具有生物活性的肽的生产方法，包括：（i）鉴定与分子的免疫球蛋白超家族的成员同源的目的蛋白质的区域; （ii）合成包含在同源性区域中发现的氨基酸序列的肽; 和（iii）修饰合成肽，使其呈现生物活性的三维构象。 本发明部分基于以下发现：包含衍生自针对病毒受体分子的抗体的CDR的氨基酸序列的环肽可用于有效抑制病毒与其受体的结合。 本发明也部分地基于以下发现：对应于与免疫球蛋白同源的人免疫缺陷病毒（HIV）gp120的一部分的环肽可用于产生抗HIV免疫应答。

    BIOCIDAL MOLECULES, MACROMOLECULAR TARGETS AND METHODS OF PRODUCTION AND USE
    89.
    发明公开
    BIOCIDAL MOLECULES, MACROMOLECULAR TARGETS AND METHODS OF PRODUCTION AND USE 审中-公开
    BIOZIDMOLEKÜLE，大分子靶和方法生产和使用

    公开(公告)号：EP1252517A2

    公开(公告)日：2002-10-30

    申请号：EP01902126.0

    申请日：2001-01-19

    申请人： THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY ,  CREIGHTON UNIVERSITY

    发明人： OTVOS, Laszio ,  BLASZCZYK-THURIN, Magdalena ,  ROGERS, Mark ,  LOVAS, Sandor

    IPC分类号： G01N33/566

    CPC分类号： C12Q1/18 ,  G01N33/68 ,  G01N2500/04

    摘要： A method for identifying a compound that has a biocidal effect against a selected organism involves screening from among known or unknown peptide or non-peptide molecules, a test molecule that binds selectively to a target sequence of a multi-helical lid of a heat shock protein of the organism. The binding of the test compound inhibits the protein folding activity of the protein. A specific embodiment of such a method is useful for identifying or designing a pharmaceutical or veterinary biocidal or antibiotic compound, preferably a pathogen and/or strain-specific compound. For this purpose, the compound does not bind to a heat shock protein that is homologous to the mammalian subject to be treated with the compound. Screening methods can encompass direct binding or competitive assays. Molecules or compounds identified by these methods are employed as biocides for pharmaceutical, veterinary, pesticide, insecticide and rodenticide uses, among others.