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公开(公告)号：EP4461354A2
公开(公告)日：2024-11-13
申请号：EP24193389.4
申请日：2010-11-11
申请人： Astellas Pharma Inc. , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , KOSLOWSKI, Michael , WALTER, Korden , WÖLL, Stefan , KREUZBERG, Maria , HUBNER, Bernd , ERDELJAN, Michael
IPC分类号： A61P1/18
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing Claudin-6 (CLDN6), including tumor-related diseases such as ovarian cancer, lung cancer, gastric cancer, breast cancer, hepatic cancer, pancreatic cancer, skin cancer, malignant melanoma, head and neck cancer, sarcoma, bile duct cancer, cancer of the urinary bladder, kidney cancer, colon cancer, placental choriocarcinoma, cervical cancer, testicular cancer, and uterine cancer.
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公开(公告)号：EP4368702A3
公开(公告)日：2024-08-14
申请号：EP24165309.6
申请日：2018-09-11
申请人： BioNTech SE , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
IPC分类号： C07K14/005 , C12N5/074
CPC分类号： C07K14/005 , C12N5/0696 , C12N2501/0020130101 , C12N2760/1202220130101 , C12N2501/60220130101 , C12N2501/60320130101 , C12N2501/60420130101 , C12N2501/60520130101 , C12N2501/60620130101 , C12N2501/60820130101 , C12N2501/6520130101 , C12N2510/0020130101 , Y02A50/30
摘要： The present invention describes a virus-derived factor which when provided to cells, e.g., by transfecting the cells with RNA encoding the virus-derived factor, enhances expression of RNA encoding a peptide or protein in the cells. In particular, the virus-derived factor enhances survival of cells, in particular when transfected repetitively with RNA, and reduces an IFN response of cells to transfected RNA. Accordingly, the present invention provides methods and means for enhancing expression of RNA in cells. The cells are preferably transfected with the RNA.
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公开(公告)号：EP4285911A3
公开(公告)日：2024-04-10
申请号：EP23200924.1
申请日：2010-02-19
申请人： Astellas Pharma Inc. , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , KOSLOWSKI, Michael , HELFTENBEIN, Gerd , KORDEN, Walter , WÖLL, Stefan , OPREA, Gabriela-Elena
IPC分类号： C12N15/11 , A61K31/7088 , C07K14/47 , C07K16/18 , A61K39/00 , A61P35/00 , A61P35/04 , A61P37/04 , C12N15/113
摘要： The present invention relates to the identification of nucleic acid and amino acid sequences that are characteristic of tumor tissues such as ovarian tumor and lung tumor tissues and which represent targets for therapy or diagnosis of tumor diseases in a subject.
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公开(公告)号：EP4331578A2
公开(公告)日：2024-03-06
申请号：EP23209136.3
申请日：2016-04-13
申请人： Astellas Pharma Inc. , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , WALTER, Korden , KREUZBERG, Maria , MITNACHT-KRAUS, Rita , LE GALL, Fabrice , JACOBS, Stefan
IPC分类号： A61K31/40
摘要： The present invention provides anti-CLDN18.2 antibody-drug conjugates which are effective for treating and/or preventing cancer diseases associated with cells expressing CLDN18.2, including gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder and metastases thereof.
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公开(公告)号：EP4178611A1
公开(公告)日：2023-05-17
申请号：EP21736343.1
申请日：2021-07-06
申请人： BioNTech SE , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , KREITER, Sebastian , DIKEN, Mustafa , VASCOTTO, Fulvia , SALOMON, Nadja , GRUNWITZ, Christian
IPC分类号： A61K39/12 , A61K39/395 , A61P31/20 , C07K16/28
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公开(公告)号：EP4112645A1
公开(公告)日：2023-01-04
申请号：EP22154316.8
申请日：2006-11-24
申请人： Astellas Pharma Inc. , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , USENER, Dirk , FRITZ, Stefan , UHEREK, Christoph , BRANDENBURG, Gunda , GEPPERT, Harald-Gerhard , SCHRÖDER, Anja Kristina , THIEL, Philippe
IPC分类号： C07K16/30 , A61K39/395 , A61P35/00 , C12N5/12 , A61K51/10 , A61K45/06 , C07K16/18 , C07K16/28 , A61K39/00 , A61K47/68 , A61P35/04 , A61P43/00
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD18, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder.
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公开(公告)号：EP4036119A1
公开(公告)日：2022-08-03
申请号：EP22152178.4
申请日：2013-05-06
申请人： Astellas Pharma Inc. , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , MITNACHT-KRAUS, Rita , WÖLL, Stefan
摘要： The invention relates to antibodies directed against an epitope located within the C-terminal portion of CLDN18.2 which are useful, for example, in diagnosing cancer and/or in determining whether cancer cells express CLDN18.2.
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公开(公告)号：EP3981424A1
公开(公告)日：2022-04-13
申请号：EP21191317.3
申请日：2018-04-10
申请人： BioNTech SE , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , KREITER, Sebastian , KRIENKE, Christina , PETSCHENKA, Jutta , KRANZ, Lena Mareen , DIKEN, Mustafa
摘要： The present invention relates to non-immunogenic RNA. This RNA forms the basis for the development of therapeutic agents for inducing tolerance towards an autoantigen and thus, for the treatment of autoimmune diseases.
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公开(公告)号：EP3972632A1
公开(公告)日：2022-03-30
申请号：EP20726162.9
申请日：2020-05-20
申请人： BioNTech SE , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , WEBER, David , WALTER, Carina , BAREA ROLDAN, Diana , KUNER, Ruprecht , WAGNER, Meike , SUCHAN, Martin , GANGI MAURICI, Stefania , HUBICH-RAU, Stefanie , BECKER, René
IPC分类号： A61K39/00
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公开(公告)号：EP3908328A1
公开(公告)日：2021-11-17
申请号：EP20700128.0
申请日：2020-01-09
申请人： BioNTech RNA Pharmaceuticals GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur
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