公开(公告)号：EP3186276B1

公开(公告)日：2019-07-10

申请号：EP15757434.4

申请日：2015-08-26

申请人： Amgen Inc.

发明人： O'NEILL, Jason, C. ,  KETCHEM, Randal, R. ,  LEE, Taeweon ,  CHINTALGATTU, Vishnu ,  STEVENS, Jennitte, LeAnn

IPC分类号： C07K14/81 ,  A61K38/00

公开(公告)号：EP3496744A1

公开(公告)日：2019-06-19

申请号：EP17754559.7

申请日：2017-08-07

申请人： Amgen Inc. ,  Washington University

发明人： OMINSKY, Michael, S. ,  THOMOPOULOS, Stavros

IPC分类号： A61K39/00 ,  A61K39/395 ,  A61P19/02 ,  A61P19/04 ,  C07K16/22

公开(公告)号：EP3478342A1

公开(公告)日：2019-05-08

申请号：EP17726404.1

申请日：2017-05-15

申请人： Amgen Inc.

发明人： FITZGIBBON, Sean ,  JAZAYERI, Julian

IPC分类号： A61M5/20 ,  A61M5/315 ,  A61M5/32

公开(公告)号：EP3465124A1

公开(公告)日：2019-04-10

申请号：EP17723913.4

申请日：2017-05-08

申请人： Amgen Inc.

发明人： JAZAYERI, Julian ,  FITZGIBBON, Sean ,  TAMSKY, Joshua ,  FOLK, Christopher, R.

IPC分类号： G01M7/02 ,  G01M7/08 ,  G01L7/00 ,  G01L1/00 ,  A61M5/20

公开(公告)号：EP3456344A1

公开(公告)日：2019-03-20

申请号：EP18182864.1

申请日：2014-03-12

申请人： Amgen, Inc

发明人： Hsu, Hailing ,  Zhang, Ming ,  Kannan, Gunasekaran ,  Jacobsen, Frederick W. ,  Tsuji, Wayne

IPC分类号： A61K39/00 ,  A61K39/395 ,  A61P19/02 ,  A61P29/00 ,  A61P29/02 ,  A61P37/06 ,  C07K14/00 ,  C07K16/28

摘要： Described herein are bispecific proteins specific for BAFF and B7RP1, nucleic acids encoding such proteins, methods of making such proteins, and uses for such proteins.

公开(公告)号：EP3427751A1

公开(公告)日：2019-01-16

申请号：EP18188983.3

申请日：2014-08-28

申请人： Amgen, Inc

发明人： Beers, Courtney ,  O'Neill, Jason ,  Foltz, Ian ,  Ketchem, Randal R. ,  Piasecki, Julia C.

IPC分类号： A61K39/395 ,  A61K45/06 ,  C07K16/28 ,  A61K39/00

摘要： Antigen binding proteins that activate GITR are provided. Nucleic acids encoding the antigen binding proteins and vectors and cells containing such nucleic acids are also provided. The antigen binding proteins have value in therapeutic methods in which it is useful to stimulate GITR signaling, thereby inducing or enhancing an immune response in a subject. Accordingly, the antigen binding proteins have utility in a variety of immunotherapy treatments, including treatment of various cancers and infections.

公开(公告)号：EP3149480B1

公开(公告)日：2018-12-26

申请号：EP15727072.9

申请日：2015-05-20

申请人： Amgen Research (Munich) GmbH ,  Amgen Inc.

发明人： ZUGMAIER, Gerhard ,  KUFER, Peter ,  ALEKAR, Shilpa

IPC分类号： G01N33/574

CPC分类号： G01N33/57426 ,  A61K35/17 ,  A61K38/1774 ,  A61K2035/124 ,  C07K16/2803 ,  C07K16/2809 ,  C07K2317/31 ,  C07K2317/622 ,  G01N33/5091 ,  G01N2333/70503 ,  G01N2800/50 ,  G01N2800/52 ,  G01N2800/56

摘要： The present invention relates to a method for risk-stratifying subjects suffering from B-precursor acute lymphoblastic leukemia (ALL), wherein said subjects are intended for a therapy comprising administration of a CD3 binding domain. Risk-stratification is based on the determination of the amount blast cells in a bone marrow sample from said subject, and/or on the determination of the number of blast cells per 1 μl in a CSF sample from said subject. According to the category into which subjects are risk-stratified, said subjects can be appropriately treated, while their risk of a potential adverse neurological reaction can be reduced or even excluded.

公开(公告)号：EP3411402A1

公开(公告)日：2018-12-12

申请号：EP17703376.8

申请日：2017-02-02

申请人： Amgen Research (Munich) GmbH ,  Amgen Inc.

发明人： RAUM, Tobias ,  MUENZ, Markus ,  BROZY, Johannes ,  KUFER, Peter ,  HOFFMANN, Patrick ,  FRIEDRICH, Matthias ,  RATTEL, Benno ,  BOGNER, Pamela ,  WOLF, Andreas ,  POMPE, Cornelius

IPC分类号： C07K16/28

CPC分类号： C07K16/2878 ,  A61K2039/505 ,  C07K16/2809 ,  C07K2317/31 ,  C07K2317/52 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/53 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2317/94 ,  C07K2319/00

摘要： The present invention provides bispecific antibody constructs of a specific Fc modality characterized by comprising a first domain binding to BCMA, a second domain binding to an extracellular epitope of the human and/or the Macaca CD3ε chain and a third domain, which is the specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.

公开(公告)号：EP2408814B1

公开(公告)日：2018-11-21

申请号：EP10754210.2

申请日：2010-03-19

申请人： Amgen Inc.

发明人： WALKER, Kenneth, W. ,  LI, Yue-Sheng ,  BOONE, Thomas, C. ,  MIN, HoSung ,  TALVENHEIMO, Jane ,  ARORA, Taruna ,  JACOBSEN, Frederick, W. ,  DOELLGAST, George

IPC分类号： C07K16/00 ,  C12P21/08 ,  C07K16/18 ,  C07K16/44 ,  C07K19/00

CPC分类号： C07K16/44 ,  A61K39/39591 ,  A61K47/6817 ,  A61K47/6843 ,  C07K14/43504 ,  C07K14/575 ,  C07K14/605 ,  C07K14/66 ,  C07K16/00 ,  C07K16/18 ,  C07K16/248 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/00 ,  C07K2319/30 ,  C07K2319/55

摘要： Disclosed is an isolated antigen binding protein, such as but not limited to, an antibody or antibody fragment. Also disclosed are pharmaceutical compositions and medicaments comprising the antigen binding protein, isolated nucleic acid encoding it, vectors, host cells, and hybridomas useful in methods of making it. In some embodiments the antigen binding protein comprises one to twenty-four pharmacologically active chemical moieties conjugated thereto, such as a pharmacologically active polypeptide.

公开(公告)号：EP3395338A1

公开(公告)日：2018-10-31

申请号：EP18175495.3

申请日：2004-09-10

申请人： Amgen Inc.

发明人： ÁLVAREZ, Francisco J. ,  JU, Tzuchi R. ,  LIN, Hung-Ren H. ,  LAWRENCE, Glen Cary

IPC分类号： A61K31/00 ,  A61K31/135 ,  A61K9/28 ,  A61K9/20 ,  A61P5/18

CPC分类号： A61K31/135 ,  A61K9/2077 ,  A61K9/2866 ,  A61K31/00 ,  A61K31/137

摘要： The present invention relates to a pharmaceutical composition comprising a therapeutically effective amount of a calcium receptor-active compound and at least one pharmaceutically acceptable excipient, wherein the composition has a controlled dissolution profile. The present invention further relates to a method of manufacturing the pharmaceutical composition, as well as a method of treating a disease using the pharmaceutical composition.