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    BIODEGRADABLE COMPOSITIONS SUITABLE FOR CONTROLLED RELEASE
    86.
    发明公开
    BIODEGRADABLE COMPOSITIONS SUITABLE FOR CONTROLLED RELEASE 审中-公开
    生物学家ABBAUBARE ZUSAMMENSETZUNGEN ZUR KONTROLLIERTEN FREISETZUNG

    公开(公告)号：EP2691078A1

    公开(公告)日：2014-02-05

    申请号：EP12711422.1

    申请日：2012-04-02

    申请人： Ingell Technologies Holding B.V.

    发明人： PETIT, Audrey ,  BRUIN, Peter ,  LEEUW DE, Mike ,  MEIJBOOM, Ronald

    IPC分类号： A61K9/06 ,  A61K47/34 ,  A61K49/04 ,  C08G63/08 ,  C08G63/91 ,  C08L67/04

    CPC分类号： A61K47/34 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/06 ,  A61K47/10 ,  A61K47/30 ,  A61K49/0438 ,  A61K49/0442 ,  A61K49/0457 ,  A61K51/065 ,  C08G63/664 ,  C08L67/04

    摘要： Simple mixing/blending of a special class of drug-depot forming tri-block copolymers polymers, with the opportunity to cost-effectively tailor drug delivery performances of such biodegradable, injectable depots in a clinical and an industrial setting. How to visualize these depots for various imaging related purposes is described. A composition comprising (a) an active ingredient, preferably a pharmaceutically active ingredient (b) a solvent and (c) a mixture of at least two types of tri-block copolymers of formula (1) B-A-B  (1) wherein B stands for a hydrophobic block and wherein A stands for a hydrophilic block, wherein the mixture is prepared by mixing at least two types of tri-block copolymers having a degree of modification of 100% and wherein the at least two types of B-A-B types of tri-block copolymers differ only on the type of end-group or wherein the mixture is prepared by mixing at least two types of tri-block copolymers, wherein one of the at least two tri-block copolymers has a degree of modification of 100% and one of the at least two tri-block copolymers has a degree of modification of 0% and wherein the at least two types of B-A-B types of tri-block copolymers differ only on the degree of modification of the end-groups.

    摘要翻译： 简单混合/混合特殊类型的药物储库形成三嵌段共聚物聚合物，有机会在临床和工业环境中经济高效地定制这种可生物降解的可注射储库的药物递送性能。 描述了如何可视化各种成像相关目的的这些仓库。 一种组合物，其包含（a）活性成分，优选药物活性成分（b）溶剂和（c）至少两种式（1）BAB（1）的三嵌段共聚物的混合物，其中B代表 疏水嵌段，其中A代表亲水嵌段，其中混合物是通过混合至少两种具有100％改性度的三嵌段共聚物并且其中至少两种类型的BAB类型的三嵌段共聚物 仅根据端基的类型而不同，或者其中通过混合至少两种三嵌段共聚物制备混合物，其中所述至少两种三嵌段共聚物之一具有100％的改性度和其中一种 至少两种三嵌段共聚物的修饰度为0％，其中至少两种类型的BAB类型的三嵌段共聚物仅在端基的修饰程度上不同。