公开(公告)号：EP2081909A1

公开(公告)日：2009-07-29

申请号：EP07822222.1

申请日：2007-11-05

申请人： BASF SE

发明人： SUKOPP, Martin ,  KUHN, Oliver ,  GRÖNING, Carsten ,  KEIL, Michael ,  LONGLET, Jon J.

IPC分类号： C07D231/44 ,  A01N43/56 ,  A01N43/00 ,  A61K31/415 ,  A61P33/00

CPC分类号： C07D231/44 ,  A01N43/56

摘要： The present invention relates to a process for the sulfinylation of a pyrazole derivative, characterized in that 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-1H-pyrazole-3-carbonitrile (II) is reacted with a sulfinylating agent S in the presence of at least one amine acid complex wherein the amine(s) are selected from cyclic secondary amines and the acid(s) are selected from sulfonic acid derivatives, and with the addition of a halogenating agent, wherein S is [CF3S(O)]2O; or CF3S(O)X wherein X means fluoro, chloro, bromo, iodo, a hydroxy group, or an alkaline or alkaline earth metal salt of the hydroxy group; or mixtures thereof.

摘要翻译： 本发明涉及吡唑衍生物的亚磺酰化方法，其特征在于5-氨基-1- [2,6-二氯-4-（三氟甲基）苯基] -1H-吡唑-3-甲腈（II）为 在至少一种胺酸络合物存在下与亚磺酰化剂S反应，其中胺（一种或多种）选自环状仲胺，并且酸选自磺酸衍生物，并且通过加入卤化剂， 其中S是[CF 3 S（O）] 2 O; 或CF 3 S（O）X，其中X表示氟，氯，溴，碘，羟基或羟基的碱金属或碱土金属盐; 或其混合物。

公开(公告)号：EP0976737B1

公开(公告)日：2009-06-10

申请号：EP98911219.8

申请日：1998-04-06

申请人： NIHON NOHYAKU CO., LTD.

发明人： OKUI, Shuko, Mitsub. Chem. Co. Yokohama Res. Cent ,  KYOMURA, Nobuo, Mitsubishi Chem. Co. ,  FUKUCHI, Toshiki, Mitsubishi Chem. Corp. ,  TANAKA, Ken, Mitsubishi Chem. Corp.

IPC分类号： C07D231/44 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D231/38 ,  A01N43/56

CPC分类号： C07D401/12 ,  A01N43/56 ,  A01N43/78 ,  A01N47/02 ,  C07D231/44 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12

摘要： 1-Aryl-3-cyano-5-(hetero)arylalkylaminopyrazole derivatives represented by general formula (1), a process for preparing the same, intermediates, and a pest control agent containing the same as the active ingredient, wherein R1 represents a C1 to C4 alkyl group or a C1 to C8 haloalkyl group; R2 represents a hydrogen atom or a C1 to C4 alkyl group; R3 represents an aryl or heteroaryl group optionally substituted with a substituent selected from among a hydrogen atom, a hydroxyl group, a C1 to C4 alkyl group, a C1 to C8 haloalkyl group, a C1 to C4 alkoxy group, an optionally substituted phenoxy group, a C1 to C4 haloalkoxy group, a C1 to C4 alkylthio group, a C1 to C4 alkylsulfinyl group, a C1 to C4 alkylsulfonyl group, a halogen atom, a nitro group, and a cyano group; R4 represents a hydrogen atom, a C1 to C4 alkyl group, or a C1 to C4 acyl group; X represents a nitrogen atom, or a carbon atom substituted with a halogen atom; and 1 and n are each independently any one of 0, 1 and 2.

公开(公告)号：EP2051985A2

公开(公告)日：2009-04-29

申请号：EP07823379.8

申请日：2007-07-31

申请人： Sanofi-Aventis

发明人： DOERFLINGER, Gilles ,  CARRY, Jean-Christophe

IPC分类号： C07D513/04 ,  C07D277/38 ,  C07D231/44 ,  A61K31/429 ,  A61K31/4162 ,  A61P35/00

CPC分类号： C07D513/04

摘要： The invention relates to a compound having formula (I), wherein R1, R2, R3 and R4 are as defined in the claims. The claimed compounds can be used as inhibitors of kinase proteins, particularly of the Aurora or Tie2 type, for cancer treatment.

公开(公告)号：EP1928840A1

公开(公告)日：2008-06-11

申请号：EP06725326.0

申请日：2006-03-27

申请人： F. Hoffmann-La Roche AG

发明人： GILLESPIE, Paul ,  GOODNOW JR., Robert Alan ,  ZHANG, Qiang

IPC分类号： C07D231/44 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D405/04 ,  C07D409/04 ,  C07D409/14 ,  A61K31/415 ,  A61K31/4155 ,  A61K31/4439 ,  A61K31/445 ,  A61K31/4709 ,  A61K31/4725 ,  A61P3/00

CPC分类号： C07D401/06 ,  C07D231/14 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/14 ,  C07D409/14

摘要： Provided herein are compounds of the formula (I) as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II dia- betes mellitus and metabolic syndrome.

公开(公告)号：EP1838693A1

公开(公告)日：2007-10-03

申请号：EP06704557.5

申请日：2006-01-17

申请人： Merial Ltd.

发明人： SCHNATTERER, Stefan ,  MAIER, Michael ,  LOCHHAAS, Friederike ,  KNAUF, Werner ,  SEEGER, Karl

IPC分类号： C07D401/04 ,  C07D231/44 ,  A01N43/56 ,  A01N43/00

CPC分类号： A01N47/24 ,  C07D231/44

摘要： Disclosed are compounds of formula (I) or pesticidally acceptable salts thereof wherein, for example, W is =CR8- or =C(NR9R10)-, R8 is halogen, R9 and R10 are independently of one another hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocyclyl, aralkyl or heterocyclylalkyl, R1 is cyano, methyl, tfifluoromethyl or -CS-NH2, R2 is C1-C6-alkyl, C1-C6-haloalkyl, R3 is hydrogen, alkyl or cycloalkyl, R4 and R5 are alkenyl, alkynyl or cycloalkyl, R6 is haloalkyl, haloalkoxy, halogen or - SF5, R7 is halogen or alkyl, and n is 0, 1 or 2.These compounds can be used for controlling pests, especially by treatment of domestic animals.

公开(公告)号：EP1765787A1

公开(公告)日：2007-03-28

申请号：EP05750617.2

申请日：2005-06-14

申请人： Merial Limited

发明人： CHOU, David, Teh-Wei ,  KNAUF, Werner ,  MAIER, Michael ,  LOCHHAAS, Friederike ,  SEEGER, Karl

IPC分类号： C07D231/38 ,  A01N43/56 ,  C07D231/44

CPC分类号： C07D231/44 ,  C07D231/38

摘要： The invention relates to 5-(oximinoalkyl- and hydrazonalkyl-amino)pyrazole derivatives of formula (I) or salts thereof: formula (I), wherein the various symbols are as defined in the description, to processes for their preparation, to compositions thereof, and to their use for the control of pests (including arthropods and helminths).

公开(公告)号：EP1727805A1

公开(公告)日：2006-12-06

申请号：EP05715530.1

申请日：2005-02-25

申请人： Bayer CropScience S.A.

发明人： SCHNATTERER, Stefan ,  CHOU, David, Teh-Wei ,  KNAUF, Werner ,  JANS, Daniela ,  SEEGER, Karl

IPC分类号： C07D231/44 ,  C07D401/04 ,  A01N43/56

CPC分类号： C07D231/44 ,  C07D401/04

摘要： The invention relates to 1-(2,4,6-trisubstituted-phenyl)-5-amino-4-substituted-pyrazole derivatives of formula (I) or salts thereof wherein the various symbols are as defined in the description, to processes for their preparation, to compositions thereof, and to their use for the control of pests (including arthropods and helminths).

公开(公告)号：EP1483245B1

公开(公告)日：2006-08-09

申请号：EP03706583.6

申请日：2003-02-27

申请人： Bayer CropScience S.A.

发明人： CHOU, David, Teh-Wei ,  BASTIAANS, Henricus, Maria, Martinus ,  KUHLMANN, Anke ,  THÖNESSEN, Maria-Theresia ,  SCHNATTERER, Stefan ,  DÖLLER, Uwe ,  HUANG, Jamin ,  SEEGER, Karl ,  SCRIBNER, Andrew ,  PEREZ DE LEON, Adalberto, A.

IPC分类号： C07D231/44 ,  C07D401/04 ,  A01N43/56

CPC分类号： A01N43/56 ,  C07D231/44 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12

摘要： The invention relates to the use for the control of pests, of a compound which is a 5 ­substituted-alkylaminopyrazole derivative of formula (I) or a salt thereof: wherein the various symbols are as defined in the description, to novel 5-substituted-­alkylaminopyrazole derivatives and pesticidal compositions thereof, and to processes for their preparation.

公开(公告)号：EP1682538A1

公开(公告)日：2006-07-26

申请号：EP04775673.9

申请日：2004-10-26

申请人： S*Bio Pte Ltd

发明人： STUNKEL, Walter, Monterey Park Condominium, ,  WANG, Haishan ,  YIN, Zheng

IPC分类号： C07D417/04 ,  C07D407/14 ,  C07D231/44 ,  C07D307/52 ,  C07D333/38 ,  C07D409/12 ,  C07D307/68 ,  A61K31/34 ,  A61K31/381 ,  A61K31/415 ,  A61K31/426 ,  A61K31/427 ,  A61K31/421 ,  A61P35/00

CPC分类号： C07D263/34 ,  A61K31/34 ,  A61K31/381 ,  A61K31/415 ,  A61K31/421 ,  A61K31/426 ,  A61K31/427 ,  C07D231/14 ,  C07D261/18 ,  C07D263/32 ,  C07D277/28 ,  C07D277/40 ,  C07D277/42 ,  C07D277/46 ,  C07D307/54 ,  C07D307/68 ,  C07D333/38 ,  C07D333/70 ,  C07D405/10 ,  C07D405/12 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  Y02A50/409 ,  Y02A50/411

摘要： The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to biaryl containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with enzymes having histone deacetylase activities. Formula (I), where Z is a single bond or C 1 -C 4 hydrocarbon, A is an aromatic ring, B is an aromatic ring.

公开(公告)号：EP1663985A1

公开(公告)日：2006-06-07

申请号：EP04764358.0

申请日：2004-08-21

申请人： Bayer CropScience S.A.

发明人： CHOU, David, Teh-Wei ,  KNAUF, Werner ,  DÖLLER, Uwe ,  SEEGER, Karl

IPC分类号： C07D231/44 ,  C07D401/04 ,  A01N43/56

CPC分类号： C07D401/04 ,  C07D231/44

摘要： The invention relates to 5-substituted-alkylaminopyrazole derivatives of formula (I) or salts thereof wherein the various symbols are as defined in the description, to processes for their preparation, to compositions thereof, and to their use for the control of pests (including arthropods and helminths).