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公开(公告)号：EP4440661A1
公开(公告)日：2024-10-09
申请号：EP22831030.6
申请日：2022-11-28
申请人： Amgen Inc.
CPC分类号： A61M2005/313920130101 , A61M5/3129 , A61M2005/3150820130101 , A61M2209/0220130101 , G01M99/008 , G01M99/005
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公开(公告)号：EP4435105A2
公开(公告)日：2024-09-25
申请号：EP24173045.6
申请日：2016-09-28
申请人： Amgen Inc.
发明人： NIOI, Paul , COWARD, Peter , MURAWSKY, Christopher , PIPER, Derek, E. , GARCES, Fernando , ZHANG, Jun , LI, Yang , CHAN, Brian, Mingtung
IPC分类号： C12N15/113
CPC分类号： C07K16/28 , C07K2317/3020130101 , C07K2317/7720130101 , A61P9/10 , A61P9/04 , C07H21/02 , A61K39/3955 , C07K2317/7620130101 , C07K2317/9220130101 , C07K2317/9420130101 , C12N15/1138 , C12N2310/1420130101
摘要： Antigen binding proteins that interact with ASGR, ASGR-1 and/or ASGR-2 are described as well as methods of making and using such antigen binding proteins. Methods of treating and preventing cardiovascular disease by administering a pharmaceutically effective amount of ASGR, ASGR-1 and/or ASGR-2 antigen binding proteins. Methods of treating and preventing cardiovascular disease by administering a pharmaceutically effective amount of interfering RNA compositions that reduce expression of ASGR, ASGR-1 and/or ASGR-2 are described.
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公开(公告)号：EP4427113A1
公开(公告)日：2024-09-11
申请号：EP22821755.0
申请日：2022-11-04
申请人： AMGEN INC.
发明人： QUON, Christopher , ASHANI, Alireza , COLES, Andrew , SEE, Keng-tong , YIN, Desheng , GIORDANO, Sergio , TRABUCCHI, Carlo , SILVANO, Alberto
IPC分类号： G06F1/14
CPC分类号： A61M2205/5020130101 , A61M2205/357620130101 , G06F1/14
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公开(公告)号：EP4416178A1
公开(公告)日：2024-08-21
申请号：EP22801672.1
申请日：2022-10-14
发明人： BOUSTANY, Leila M. , PAIDHUNGAT, Madan M. , FOX, Ellaine Anne Mariano , MITRA, Sayantan , KAVANAUGH, W. Michael , BRIANTE, Raffaella , STEVENS, Jennitte LeAnn
IPC分类号： C07K16/28
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5.发明公开
公开(公告)号：EP4397977A2
公开(公告)日：2024-07-10
申请号：EP24167772.3
申请日：2020-02-14
申请人： Amgen Inc.
发明人： WU, Chao-Hsiang , XUE, Gang , SARICH, Brandon, Zachary , BERKE, Michael, R. , SEBASTIAN, Jacob , CHAN, Pik
IPC分类号： G01N33/68
CPC分类号： G01N2030/844120130101 , G01N2030/883120130101 , G01N2030/843520130101 , G01N2030/02720130101 , B01D15/24 , B01D15/3847 , B01D15/14 , G01N30/08 , G01N2030/08520130101 , G01N2030/20720130101 , G01N33/6848 , C07K1/16
摘要： Systems and methods that facilitate the automatic (or substantially automatic) preparation of a sample of a product containing molecules for analysis and automatic (or substantially automatic) performance of an assay of that sample. Thus, the preparation and analysis can be performed substantially in-real time, or, in other words, much more quickly than presently allowed by conventional systems and methods.
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公开(公告)号：EP3788053B1
公开(公告)日：2024-07-10
申请号：EP19725457.6
申请日：2019-05-03
IPC分类号： C07F9/6561 , A61K31/553 , A61K45/06
CPC分类号： C07F9/6561 , A61K31/553 , A61K45/06
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公开(公告)号：EP4392738A1
公开(公告)日：2024-07-03
申请号：EP22765697.2
申请日：2022-08-22
申请人： Amgen Inc.
发明人： GOODWIN, Al, Patrick , BERNACKI, Joseph, Peter , PEARSON, Thomas, Clark , MILNE, Graham, F. , PARSONS, Jonathan , BISHOP, Corey , DONOHOE, Barry , PEREZ-VARELA, Osvaldo
CPC分类号： G01B11/2522 , B29C65/8253 , G01N21/909
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公开(公告)号：EP4388311A1
公开(公告)日：2024-06-26
申请号：EP22797196.7
申请日：2022-08-19
申请人： Amgen Inc.
发明人： JOUBERT, Marisa , JOH, Nathan, H. , TOKUDA, Joshua, M. , FERBAS, John , XIE, Jiansong , XIANG, Dong
CPC分类号： G01N33/15 , C12N5/0698 , G01N33/5082 , G01N33/5044 , C07K16/00 , C07K2317/9420130101
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公开(公告)号：EP4387951A1
公开(公告)日：2024-06-26
申请号：EP22768536.9
申请日：2022-08-17
申请人： Amgen Inc.
发明人： ORTIZ, Adrian , DOERFLER, Jaika , VAIDA, Karina R.
IPC分类号： C07C201/14 , C07C205/58 , C07C319/14 , C07C319/20 , C07C323/62 , C07C323/63 , C12P13/00
CPC分类号： C07C201/14 , C07C319/14 , C07C323/63 , C07C319/20 , C12P13/001
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公开(公告)号：EP4335510A3
公开(公告)日：2024-06-26
申请号：EP23219258.3
申请日：2008-09-17
申请人： Amgen Inc.
IPC分类号： A61K39/395 , A61P19/08 , C07K16/18 , A61K39/00 , A61P1/02 , A61P1/04 , A61P1/16 , A61P3/00 , A61P3/04 , A61P3/10 , A61P5/00 , A61P7/06 , A61P15/00 , A61P19/00 , A61P19/02 , A61P19/10 , A61P25/00 , A61P25/08 , A61P25/32 , A61P29/00 , A61P31/08
CPC分类号： A61K2039/50520130101 , C07K16/18 , A61P1/02 , A61P1/04 , A61P1/16 , A61P15/00 , A61P19/00 , A61P19/02 , A61P19/08 , A61P19/10 , A61P25/00 , A61P25/08 , A61P25/32 , A61P29/00 , A61P3/00 , A61P3/04 , A61P31/08 , A61P5/00 , A61P7/06 , A61P3/10
摘要： The invention provides an anti-sclerostin antibody or sclerostin-binding fragment thereof for use in a method for treating a bone-related disorder in a human by administering the anti-sclerostin antibody or fragment thereof in an amount from 0.1 mg/kg to 20 mg/kg.
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