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    DIAGNOSTIC METHOD FOR DISORDERS USING COPEPTIN
    3.
    发明授权
    DIAGNOSTIC METHOD FOR DISORDERS USING COPEPTIN 有权
    使用丙泊酚诊断疾病的方法

    公开(公告)号：EP1738178B1

    公开(公告)日：2007-10-10

    申请号：EP05782853.5

    申请日：2005-08-19

    申请人： BRAHMS Aktiengesellschaft

    发明人： BERGMANN, Andreas ,  STRUCK, Joachim

    IPC分类号： G01N33/74

    CPC分类号： G01N33/6893 ,  G01N33/74 ,  G01N2333/575 ,  G01N2333/5757 ,  Y10S930/15

    摘要： The use of copeptin as diagnostic marker for the determination of the physiological release of vasopressin, especially in connection with the diagnosis, prognosis and the monitoring of the course of diseases as cardiac diseases, shock, including septic shock, sepsis and various types of cancer and tumours.

    摘要翻译： 和肽素作为诊断标志物用于测定加压素的释放，特别是与神经垂体释放的血管加压素释放的非生理学改变有关的疾病，特别是用于检测和早期检测，诊断和监测心血管疾病过程 ，肾脏和肺部疾病以及休克，包括感染性休克，败血症和中枢神经系统疾病/病症和神经退行性疾病。

    VERFAHREN ZUR DETEKTION VON ANALYTEN
    4.
    发明公开
    VERFAHREN ZUR DETEKTION VON ANALYTEN 有权
    检测方法的分析物

    公开(公告)号：EP2167965A1

    公开(公告)日：2010-03-31

    申请号：EP08761286.7

    申请日：2008-06-20

    申请人： BRAHMS Aktiengesellschaft

    发明人： BERGMANN, Andreas ,  STRUCK, Joachim

    IPC分类号： G01N33/543

    CPC分类号： G01N33/54306

    摘要： The present invention relates to a method for detecting analytes of biological samples, said method comprising the following method steps of: a) providing a reversible binding partner 1 which is immobilized on a solid phase and to which an analyte binder is reversibly bound via a reversible binding partner 2 which is bound to the analyte binder, wherein the analyte binder is immobilized by binding the reversible binding partners 1 and 2, b) adding the biological sample and binding the analyte to the reversibly immobilized analyte binder in the event that the biological sample contains the analyte, c) separating the biological sample, d) adding a stripping buffer which dissolves the bond between the reversible binding partners 1 and 2, wherein the bond between the analyte and the analyte binder optionally remains, and e) detecting the analyte in the stripping buffer in the event that the biological sample contains the analyte or determining the absence of the analyte in the event that the biological sample does not contain the analyte.

    A marker for graft failure and mortality
    6.
    发明公开
    A marker for graft failure and mortality 审中-公开
    MarkerfürTransplantatabstossung und Sterblichkeit

    公开(公告)号：EP2131200A1

    公开(公告)日：2009-12-09

    申请号：EP08157595.3

    申请日：2008-06-04

    申请人： BRAHMS Aktiengesellschaft

    发明人： Struck, Joachim ,  Bakker, S.J.L.

    IPC分类号： G01N33/68 ,  G01N33/74

    CPC分类号： G01N33/6893 ,  G01N33/74 ,  G01N2333/585 ,  G01N2800/245

    摘要： Subject of the present invention is a biomarker for graft failure and/or mortality after organ transplantation. Procalcitonin was found to be a useful marker for the prediction of risk stratification for graft failure and/or mortality of a subject who has received an organ transplant and monitoring and therapy guidance of such subject.

    摘要翻译： 本发明的主题是器官移植后移植物衰竭和/或死亡率的生物标志物。 发现降钙素原是预测接受器官移植的受试者的移植物衰竭和/或死亡率的风险分层和对该受试者的监测和治疗指导的有用标志物。