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公开(公告)号：EP1594628B1
公开(公告)日：2013-06-26
申请号：EP04703983.9
申请日：2004-01-21
IPC分类号： C08J3/215
CPC分类号： C08J3/212 , C08J3/215 , C08J3/22 , C08J2325/08
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公开(公告)号：EP1969373A4
公开(公告)日：2010-05-26
申请号：EP07716339
申请日：2007-01-04
发明人： BANERJEE SUKANTA
CPC分类号： G01N33/80 , Y10T436/106664 , Y10T436/13 , Y10T436/2525
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3.发明公开A TRANSFUSION REGISTRY AND EXCHANGE NETWORK 审中-公开TRANSFUSIONS-REGISTRIERUNGS- UND AUSTAUSCHNETZWERK
公开(公告)号：EP2013801A4
公开(公告)日：2009-05-27
申请号：EP07761283
申请日：2007-04-25
发明人： ZHANG YI , SEUL MICHAEL
CPC分类号： G06F19/327 , G06Q30/02 , G06Q30/0202 , G06Q50/22 , G06Q50/24 , G16H40/20
摘要： Disclosed is a registry for candidate transfusion donors, which invokes an inventory management policy to create and actively manage lists of candidate donors in order to minimize imbalances between demand and supply across multiple regions and across multiple categories of donors and recipients. Together with a genotyping laboratory, the registry does targeted recruitment of prospective donors who are typed for a set of genetic markers relating to clinically relevant antigens including mutations of Human Erythrocyte Antigens (HEA), genetic variants of Rh, and possibly additional antigens such as HLA and HPA. The registry monitors incoming demand for transfusion antigen genotypes, preferably stratify the demand into a set of categories representing stable subpopulations, and will apply strategies, disclosed herein, to tune the composition of candidate donor lists to match the demand, thereby avoiding excess, and unnecessary, typing of candidate donors.
摘要翻译： 公开了候选输血捐献者的登记处，该登记处引用库存管理政策来创建并积极管理候选捐献者名单，以便最小化跨多个地区和多个类别的捐赠者和接受者的需求与供应之间的不平衡。 登记处与基因分型实验室一起，确实有针对性地招募预期捐赠者，这些捐赠者被输入一系列与临床相关抗原相关的遗传标记，包括人类红细胞抗原（HEA）的突变，Rh的遗传变体，以及可能的额外抗原如HLA 和HPA。 注册表监测输入抗原基因型的输入需求，优选将需求分层为表示稳定亚群的一组类别，并且将应用本文公开的策略来调整候选供体列表的组成以匹配需求，从而避免过量且不必要的 ，输入候选捐助者。
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4.发明公开GENOTYPING OF MULTIPLE LOCI WITH PCR FOR DIFFERENT LOCI AMPLIFICATION AT DIFFERENT TEMPERATURES 审中-公开基因分型多个位点的手段，进行PCR扩增不同基因座在不同的温度
公开(公告)号：EP1756312A4
公开(公告)日：2008-11-05
申请号：EP05750553
申请日：2005-05-17
发明人： YANG JIACHENG
CPC分类号： C12Q1/6881 , C07H21/04 , C12Q1/686 , C12Q2600/16 , C12Q2527/15 , C12Q2537/143 , C12Q2527/101
摘要： Disclosed is a method of performing simulltaneous PCR amplification of several designated different loci in a sample each including a different target subsequence, using a set of pairs of forward and reverse primers, wherein the pairs are complementary to target subsequences, where different primer pairs are in different reaction chambers and the sample is also present in the reaction chambers, and wherein different primer pairs have different sequences. Different reaction chambers are provided different annealing temperatures, preferably at the same time, such that the annealing temperatures selected enhance annealing conditions for the primer pairs and the target subsequences within the reaction chambers. The method allows PCR to proceed more quickly, which is important to increase throughput in a multiplexed assay, and can be particularly important for HLA-typing in a transplantation setting.
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5.发明公开
公开(公告)号：EP1692298A4
公开(公告)日：2008-08-13
申请号：EP04817449
申请日：2004-10-26
发明人： SEUL MICHAEL , BANERJEE SUKANTA , YANG JIACHENG , VENER TATIANA
IPC分类号： C12Q1/68 , C12Q20060101
CPC分类号： C12Q1/6832 , B01J2219/00459 , B01J2219/00576 , B01J2219/00608 , B01J2219/00648 , B01J2219/00722 , C12Q1/6809 , C12Q1/6834 , C12Q1/6837 , C12Q2537/143 , C12Q2565/501 , C12Q2565/507 , C12Q2533/101 , C12Q2565/514 , C12Q2565/519
摘要： Disclosed are methods of multiplexed analysis of oligonucleotides in a sample, including: methods of probe and target “engineering”, as well as methods of assay signal analysis relating to the modulation of the probe-target affinity constant, K by a variety of factors including the elastic properties of target strands and layers of immobilized (“grafted”) probes; and assay methodologies relating to: the tuning of assay signal intensities including dynamic range compression and on-chip signal amplification; the combination of hybridization-mediated and elongation-mediated detection for the quantitative determination of abundance of messages displaying a high degree of sequence similarity, including, for example, the simultaneous determination of the relative expression levels, and identification of the specific class of, untranslated AU-rich subsequences located near the 3′ terminus of mRNA; and a new method of subtractive differential gene expression analysis which requires only a single color label.
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6.发明公开A METHOD OF NUCLEIC ACID TYPING FOR SELECTING REGISTERED DONORS FOR CROSS-MATCHING TO TRANSFUSION RECIPIENTS 有权对于核酸分型方法的选择登记捐助者CROSS样本输血RECEIVERS
公开(公告)号：EP1805326A4
公开(公告)日：2008-07-09
申请号：EP05816073
申请日：2005-10-24
发明人： SEUL MICHAEL , HASHMI GHAZALA , PIERCE MICHAEL
CPC分类号： C12Q1/6881 , C12Q2600/156 , C12Q2600/16
摘要： Disclosed are a method and an algorithm for genetic cross-matching based on the comparison of recipient and donor genotypes - and the underlying combinations of alleles and haplotypes. The method of the invention, rather than focusing on phenotype prediction, instead relies on a comparison of genetic variants identified in the recipient and available donors, whose information preferably will be compiled in a widely available donor registry, to maximize molecular compatibility. The genotypes can be matched based on the weighted clinical significance of a genotypic difference between donor and recipient, such that certain mismatches are more acceptable than others.
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公开(公告)号：EP1543163A4
公开(公告)日：2008-05-21
申请号：EP03794568
申请日：2003-09-04
发明人： HASHMI GHAZALA , SEUL MICHAEL , MESSING JOACHIM
CPC分类号： C12Q1/6827 , B82Y5/00 , B82Y10/00 , B82Y20/00 , C12Q1/6837 , C12Q2565/102 , C12Q2563/149 , C12Q2537/143
摘要： This invention provides compositions and methods for genetic testing of an organism and for correlating the results of the genetic testing with a unique marker that unambiguously identifies the organism. The marders may be internal markers, such as for example single nucleotide polymorphisms (SNPs), short tandem repeats (STRs), or other sites within a genomic locus. Alternatively, the markers may be external, such that they are separately added to the genetic sample before testing.
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8.发明公开MULTIPLEXED NUCLEIC ACID ANALYSIS BY FRAGMENTATION OF DOUBLE-STRANDED DNA 有权MULTIPLEX-NUKLEINSÄUREANALYSEMITTELS FRAGMENTIERUNGDOPPELSTRÄNGIGERDNA
公开(公告)号：EP1694859A4
公开(公告)日：2007-08-08
申请号：EP04796412
申请日：2004-10-26
发明人： YANG JIACHENG
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6827 , C12Q2565/519 , C12Q2523/107
摘要： A method of fragmentation of double stranded DNA is disclosed for use in nucleic acid analysis, notably in the multiplexed analysis of polymorphisms and mutations. The method produces a multiplicity of labeled sense and anti-sense fragments which are not complementary, and thus do not significantly re-anneal under conditions suitable for hybridization analysis (or capture-mediated elongation analysis) of the polymorphisms and/or mutations. The fragments display a desired or predicted length distribution. Cleavage sites can be selected such that the fragments are short, yet long enough to allow discrimination among fragments in an assay, and as a matter of statistical probability, such that the majority of fragments contain at least one labeled nucleotide to facilitate detection.
摘要翻译： 公开了用于核酸分析的双链DNA片段化方法，特别是在多态性和突变的多重分析中。 该方法产生多个标记的有义和反义片段，它们不互补，因此在适合于多态性和/或突变的杂交分析（或捕获介导的延伸分析）的条件下不显着再退火。 该片段显示期望的或预测的长度分布。 可以选择切割位点，使得片段短而足够长以允许在测定中片段之间的区分，并且作为统计概率的问题，使得大多数片段含有至少一个标记的核苷酸以便于检测。
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9.发明公开A METHOD OF NUCLEIC ACID TYPING FOR SELECTING REGISTERED DONORS FOR CROSS-MATCHING TO TRANSFUSION RECIPIENTS 有权对于核酸分型方法的选择登记捐助者CROSS样本输血RECEIVERS
公开(公告)号：EP1805326A2
公开(公告)日：2007-07-11
申请号：EP05816073.0
申请日：2005-10-24
发明人： SEUL, Michael , HASHMI, Ghazala , PIERCE, Michael
CPC分类号： C12Q1/6881 , C12Q2600/156 , C12Q2600/16
摘要： Disclosed are a method and an algorithm for genetic cross-matching based on the comparison of recipient and donor genotypes-and the underlying combinations of alleles and haplotypes. The method of the invention, rather than focusing on phenotype prediction, instead relies on a comparison of genetic variants identified in the recipient and available donors, whose information preferably will be compiled in a widely available donor registry, to maximize molecular compatibility. The genotypes can be matched based on the weighted clinical significance of a genotypic difference between donor and recipient, such that certain mismatches are more acceptable than others.
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10.发明授权MULTIANALYTE MOLECULAR ANALYSIS USING APPLICATION-SPECIFIC RANDOM PARTICLE ARRAYS 有权多分析分子分析使用应用程序特定的随机粒子阵列
公开(公告)号：EP1311839B1
公开(公告)日：2006-03-01
申请号：EP01952210.1
申请日：2001-06-21
IPC分类号： G01N33/543 , C12Q1/68 , G01N33/533 , B05D5/12 , B05D5/06 , G01N27/447
CPC分类号： C12Q1/6813 , B01J19/0046 , B01J2219/00286 , B01J2219/00315 , B01J2219/00497 , B01J2219/005 , B01J2219/00527 , B01J2219/00545 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00644 , B01J2219/00648 , B01J2219/00653 , B01J2219/00722 , B01J2219/00725 , C12Q1/6837 , C12Q1/6876 , G01N27/745 , G01N33/5434 , G01N33/54346 , G01N33/587 , G01N2035/00564 , G01N2035/00762 , G01N2446/20 , G01N2446/64 , Y10T436/11 , C12Q2565/513 , C12Q2563/143 , C12Q2563/107 , C12Q2563/155
摘要： The present invention provides methods and apparatus for the application of a particle array in bioassay format to perform qualitative and/or quantitative molecular interaction analysis between two classes of molecules (an analyte and a binding agent). The methods and apparatus disclosed herein permit the determination of the presence or absence of association, the strength of association, and/or the rate of association and dissociation governing the binding interactions between the binding agents and the analyte molecules. The present invention is especially useful for performing multiplexed (parallel) assays for qualitative and/or quantitative analysis of binding interactions of a number of analyte molecules in a sample.
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