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    A TRANSFUSION REGISTRY AND EXCHANGE NETWORK
    3.
    发明公开
    A TRANSFUSION REGISTRY AND EXCHANGE NETWORK 审中-公开
    TRANSFUSIONS-REGISTRIERUNGS- UND AUSTAUSCHNETZWERK

    公开(公告)号：EP2013801A4

    公开(公告)日：2009-05-27

    申请号：EP07761283

    申请日：2007-04-25

    申请人： BIOARRAY SOLUTIONS LTD

    发明人： ZHANG YI ,  SEUL MICHAEL

    IPC分类号： G06F19/00 ,  G06F17/00

    CPC分类号： G06F19/327 ,  G06Q30/02 ,  G06Q30/0202 ,  G06Q50/22 ,  G06Q50/24 ,  G16H40/20

    摘要： Disclosed is a registry for candidate transfusion donors, which invokes an inventory management policy to create and actively manage lists of candidate donors in order to minimize imbalances between demand and supply across multiple regions and across multiple categories of donors and recipients. Together with a genotyping laboratory, the registry does targeted recruitment of prospective donors who are typed for a set of genetic markers relating to clinically relevant antigens including mutations of Human Erythrocyte Antigens (HEA), genetic variants of Rh, and possibly additional antigens such as HLA and HPA. The registry monitors incoming demand for transfusion antigen genotypes, preferably stratify the demand into a set of categories representing stable subpopulations, and will apply strategies, disclosed herein, to tune the composition of candidate donor lists to match the demand, thereby avoiding excess, and unnecessary, typing of candidate donors.

    摘要翻译： 公开了候选输血捐献者的登记处，该登记处引用库存管理政策来创建并积极管理候选捐献者名单，以便最小化跨多个地区和多个类别的捐赠者和接受者的需求与供应之间的不平衡。 登记处与基因分型实验室一起，确实有针对性地招募预期捐赠者，这些捐赠者被输入一系列与临床相关抗原相关的遗传标记，包括人类红细胞抗原（HEA）的突变，Rh的遗传变体，以及可能的额外抗原如HLA 和HPA。 注册表监测输入抗原基因型的输入需求，优选将需求分层为表示稳定亚群的一组类别，并且将应用本文公开的策略来调整候选供体列表的组成以匹配需求，从而避免过量且不必要的 ，输入候选捐助者。

    SELECTION OF GENOTYPED TRANSFUSION DONORS BY CROSS-MATCHING TO GENOTYPED RECIPIENTS
    8.
    发明公开
    SELECTION OF GENOTYPED TRANSFUSION DONORS BY CROSS-MATCHING TO GENOTYPED RECIPIENTS 审中-公开
    基因分型，输血献血者用CROSS基因型RECEIVERS比较选择

    公开(公告)号：EP1941414A4

    公开(公告)日：2010-03-17

    申请号：EP06826464

    申请日：2006-10-23

    申请人： BIOARRAY SOLUTIONS LTD

    发明人： ZHANG YI ,  SEUL MICHAEL

    IPC分类号： G06F19/00 ,  G06F19/18 ,  G06F19/20 ,  G06F19/24

    CPC分类号： G06F19/3456 ,  G06F19/18 ,  G06F19/20 ,  G06F19/22 ,  G06F19/24 ,  G06F19/3481 ,  G16H10/60 ,  G16H50/70

    摘要： Disclosed are methods for establishing the compatibility between two bloodtypes on the basis of cross-matching (under a designated rule of stringency) the minor blood group genotypes of recipient and prospective donors. To determine compatibility, the blood group genotypes are mapped to corresponding phenotypes according to the expression states associated with a set of underlying haplotypes, and compatibility is established by establishing the compatibility of bloodtypes constructed as a combination of constituent phenotypes. The bit strings are matched, preferably using an algorithm expression. Where ambiguity in mapping genotypes to haplotypes exists, it can be reduced based on frequency of occurrence of the haplotypes in the sample population, or resolved by gametic phasing. Such reduction or resolution of ambiguity is particularly desirable where mismatches in the antigens expressed by the constituent haplotypes have greater clinical significance.

    AUTOMATED ANALYSIS OF MULTIPLEXED PROBE-TRAGET INTERACTION PATTERNS: PATTERN MATCHING AND ALLELE IDENTIFICATION
    9.
    发明公开
    AUTOMATED ANALYSIS OF MULTIPLEXED PROBE-TRAGET INTERACTION PATTERNS: PATTERN MATCHING AND ALLELE IDENTIFICATION 有权
    AUTOMATED交互模式分析复用器样品取样目标和比较ALLELIDENTIFIKATION

    公开(公告)号：EP1774323A4

    公开(公告)日：2008-09-03

    申请号：EP05789862

    申请日：2005-08-02

    申请人： BIOARRAY SOLUTIONS LTD

    发明人： XIONGWU XIA ,  SEUL MICHAEL

    IPC分类号： C12Q1/68 ,  G01N33/48

    CPC分类号： C12Q1/6827 ,  G06F19/18 ,  G06F19/22

    摘要： Disclosed are methods and algorithms (and their implementation) supporting the automated analysis and interactive review and refinement ("redaction") of the analysis within an integrated software environment, for automated allele assignments. The implementation, preferably with a software system and a program referred to as the Automated Allele Assignment ("AAA") program, provides a multiplicity of functionalities including: data management by way of an integrated interface to a portal a database to permit visualizing, importing, exporting and creating customizable summery reports; system configuration ("Set-up") including user authorization, training set analysis and probe masking; Pattern Analysis including string matching and probe flipping; and Interactive Redaction combining real-time database computations and "cut-and­paste" editing, generating "warning" statements and supporting annotation. It also includes a thresholding function, a method of setting thresholds, a method of refining thresholds by matching an experimental binary string ("reaction pattern") setting for that probe, probe masking of signals produced by probes which do not contribute significantly to discriminating among alleles.