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    SELECTION OF GENOTYPED TRANSFUSION DONORS BY CROSS-MATCHING TO GENOTYPED RECIPIENTS
    4.
    发明公开
    SELECTION OF GENOTYPED TRANSFUSION DONORS BY CROSS-MATCHING TO GENOTYPED RECIPIENTS 审中-公开
    基因分型，输血献血者用CROSS基因型RECEIVERS比较选择

    公开(公告)号：EP1941414A4

    公开(公告)日：2010-03-17

    申请号：EP06826464

    申请日：2006-10-23

    申请人： BIOARRAY SOLUTIONS LTD

    发明人： ZHANG YI ,  SEUL MICHAEL

    IPC分类号： G06F19/00 ,  G06F19/18 ,  G06F19/20 ,  G06F19/24

    CPC分类号： G06F19/3456 ,  G06F19/18 ,  G06F19/20 ,  G06F19/22 ,  G06F19/24 ,  G06F19/3481 ,  G16H10/60 ,  G16H50/70

    摘要： Disclosed are methods for establishing the compatibility between two bloodtypes on the basis of cross-matching (under a designated rule of stringency) the minor blood group genotypes of recipient and prospective donors. To determine compatibility, the blood group genotypes are mapped to corresponding phenotypes according to the expression states associated with a set of underlying haplotypes, and compatibility is established by establishing the compatibility of bloodtypes constructed as a combination of constituent phenotypes. The bit strings are matched, preferably using an algorithm expression. Where ambiguity in mapping genotypes to haplotypes exists, it can be reduced based on frequency of occurrence of the haplotypes in the sample population, or resolved by gametic phasing. Such reduction or resolution of ambiguity is particularly desirable where mismatches in the antigens expressed by the constituent haplotypes have greater clinical significance.

    AUTOMATED ANALYSIS OF MULTIPLEXED PROBE-TRAGET INTERACTION PATTERNS: PATTERN MATCHING AND ALLELE IDENTIFICATION
    5.
    发明公开
    AUTOMATED ANALYSIS OF MULTIPLEXED PROBE-TRAGET INTERACTION PATTERNS: PATTERN MATCHING AND ALLELE IDENTIFICATION 有权
    AUTOMATED交互模式分析复用器样品取样目标和比较ALLELIDENTIFIKATION

    公开(公告)号：EP1774323A4

    公开(公告)日：2008-09-03

    申请号：EP05789862

    申请日：2005-08-02

    申请人： BIOARRAY SOLUTIONS LTD

    发明人： XIONGWU XIA ,  SEUL MICHAEL

    IPC分类号： C12Q1/68 ,  G01N33/48

    CPC分类号： C12Q1/6827 ,  G06F19/18 ,  G06F19/22

    摘要： Disclosed are methods and algorithms (and their implementation) supporting the automated analysis and interactive review and refinement ("redaction") of the analysis within an integrated software environment, for automated allele assignments. The implementation, preferably with a software system and a program referred to as the Automated Allele Assignment ("AAA") program, provides a multiplicity of functionalities including: data management by way of an integrated interface to a portal a database to permit visualizing, importing, exporting and creating customizable summery reports; system configuration ("Set-up") including user authorization, training set analysis and probe masking; Pattern Analysis including string matching and probe flipping; and Interactive Redaction combining real-time database computations and "cut-and­paste" editing, generating "warning" statements and supporting annotation. It also includes a thresholding function, a method of setting thresholds, a method of refining thresholds by matching an experimental binary string ("reaction pattern") setting for that probe, probe masking of signals produced by probes which do not contribute significantly to discriminating among alleles.

    Light-controlled electrokinetic assembly of particles near surfaces
    9.
    发明公开
    Light-controlled electrokinetic assembly of particles near surfaces 失效
    光控电动装配表面附近的粒子

    公开(公告)号：EP1726957A3

    公开(公告)日：2007-07-11

    申请号：EP06018875.2

    申请日：1997-04-24

    申请人： BioArray Solutions Ltd.

    发明人： Seul, Michael

    IPC分类号： G01N33/543 ,  B01J19/00 ,  C12Q1/68

    CPC分类号： G01N33/54313 ,  B01J19/0046 ,  B01J2219/00466 ,  B01J2219/00468 ,  B01J2219/00576 ,  B01J2219/00596 ,  B01J2219/00648 ,  B01J2219/00653 ,  B01J2219/00702 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01L3/502715 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2200/0663 ,  B01L2300/0819 ,  B01L2300/0877 ,  B01L2300/089 ,  B01L2400/0415 ,  B01L2400/0454 ,  G01N33/6845

    摘要： A method of detecting the formation of an analyte-biomolecule complex comprising the following steps: providing a planar array of biomolecules comprising a plurality of beads having biomolecules attached thereto, wherein the plurality of beads comprises different bead types, said bead types being distinguishable by said biomolecules and each bead type being associated with a unique chemical or physical characteristic that identifies the biomolecules attached to said bead type, wherein beads are arranged in a planar array and biomolecules attached to said beads are exposed to a contiguous liquid phase, said biomolecules capable of forming complexes with corresponding analyte compounds, when said analyte compounds are present in said liquid phase; contacting the biomolecules with a sample that may contain one or more analyte compounds such that, if the analytes are present in the sample, said analytes bind to corresponding biomolecules to form analyte-biomolecule complexes; detecting the formation of the analyte-biomolecule complexes; and identifying the biomolecules of the analyte-biomolecule complexes by correlating the location of the analyte-biomolecule complexes with particular bead types, based on the unique chemical or physical characteristics of the beads.

    摘要翻译： 一种检测分析物 - 生物分子复合物形成的方法，包括以下步骤：提供包含多个附着有生物分子的珠子的平面生物分子阵列，其中所述多个珠子包含不同的珠子类型，所述珠子类型可通过所述 生物分子和每种珠类型与识别附着于所述珠类型的生物分子的独特化学或物理特征相关联，其中珠排列成平面阵列并且附着于所述珠的生物分子暴露于连续液相，所述生物分子能够 当所述分析物化合物存在于所述液相中时，与相应的分析物化合物形成复合物; 使生物分子与可含有一种或多种分析物化合物的样品接触，使得如果分析物存在于样品中，则所述分析物结合相应的生物分子以形成分析物 - 生物分子复合物; 检测分析物 - 生物分子复合物的形成; 以及基于珠子的独特化学或物理特性，通过将分析物 - 生物分子复合物与特定珠子类型的位置关联来鉴定分析物 - 生物分子复合物的生物分子。