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公开(公告)号：EP3139745B8
公开(公告)日：2020-08-26
申请号：EP15789628.3
申请日：2015-05-08
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公开(公告)号：EP2076189B1
公开(公告)日：2020-07-22
申请号：EP07811021.0
申请日：2007-07-31
发明人： LOPEZ, Mandi, J. , MONROE, W., Todd
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3.发明公开
公开(公告)号：EP3601207A1
公开(公告)日：2020-02-05
申请号：EP18771629.5
申请日：2018-03-19
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4.发明公开
公开(公告)号：EP3411045A1
公开(公告)日：2018-12-12
申请号：EP17748126.4
申请日：2017-02-02
IPC分类号： A61K31/7048 , A61K31/7028 , A61K31/704
CPC分类号： A61K31/7048 , A61K31/4709 , A61K45/06 , A61K2300/00
摘要： A method of treating an activated fibroblast associated disease or pre-disease condition in a mammal comprising, administering a pharmaceutical composition including a therapeutically effective amount of a first therapeutic, wherein the first therapeutic is one of an intracellular Ca2+ elevator, a YAP / TAZ inhibitor, both a intracellular Ca2+ elevator and a YAP / TAZ inhibitor, or pharmacologically acceptable salts, solvates, esters, amides, clathrates, stereoisomers, enantiomers, prodrugs or analogs thereof, or a combination thereof.
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公开(公告)号：EP2979086B1
公开(公告)日：2017-11-08
申请号：EP14772704.4
申请日：2014-03-28
申请人： Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College , Louisiana Tech University Foundation
CPC分类号： G01N33/0044 , G01N27/40 , G01N31/223 , G01N33/0013 , G01N33/4925
摘要： A hydrogen sulfide (H2S) detecting apparatus for measuring the concentrations of hydrogen sulfide species in a given sample is disclosed. The hydrogen sulfide detecting apparatus can comprise a plurality of reaction chambers separated from a plurality of trapping chambers by a (H2S) permeable membrane, with the reaction chambers and trapping chambers each having buffer component(s) and/or reactive agents that expose the incoming sample to a particular pH and chemical environment in order to allow for the selective liberation and trapping of hydrogen sulfide from the sample.
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公开(公告)号：EP2252627B1
公开(公告)日：2017-04-19
申请号：EP09704677.5
申请日：2009-01-26
申请人： Esperance Pharmaceuticals , BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
发明人： LEUSCHNER, Carola , ALILA, Hector
CPC分类号： C07K14/59 , A61K38/24 , A61K45/06 , C07K7/08 , C07K14/592 , C07K2319/03 , C07K2319/55 , C07K2319/74
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7.发明公开VACCINES AGAINST GENITAL HERPES SIMPLEX INFECTIONS 审中-公开IMPFSTOFFE GEGEN INFEKINGEN MIT GENITAL-HERPES-SIMPLEX
公开(公告)号：EP3139745A1
公开(公告)日：2017-03-15
申请号：EP15789628.3
申请日：2015-05-08
摘要： The present invention provides vaccines for treating or preventing a herpes simplex virus infection and methods of using and making the vaccine. Further provided are recombinant herpes simplex virus genomes, recombinant viruses, and immunogenic compositions.
摘要翻译： 本发明提供用于治疗或预防单纯疱疹病毒感染的疫苗以及使用和制备疫苗的方法。 还提供重组单纯疱疹病毒基因组，重组病毒和免疫原性组合物。
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公开(公告)号：EP1280928B1
公开(公告)日：2016-11-30
申请号：EP01935251.7
申请日：2001-05-09
CPC分类号： C12N15/8274 , A01H5/10 , A01N43/50 , C12N9/1022 , C12N9/88 , C12N15/8278
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9.发明授权Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays 失效使用与可寻址阵列的连接酶检测反应检测核酸序列差异
公开(公告)号：EP2574617B1
公开(公告)日：2016-04-20
申请号：EP12190906.3
申请日：1997-02-05
申请人： CORNELL RESEARCH FOUNDATION, INC. , REGENTS OF THE UNIVERSITY OF MINNESOTA , Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
发明人： Barany, Francis , Barany, George , Hammer, Robert P , Kempe, Maria , Blok, Herman , Zirvi, Monib
CPC分类号： B01J19/0046 , B01J2219/00432 , B01J2219/00527 , B01J2219/00529 , B01J2219/00536 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , B01J2219/00729 , B82Y30/00 , C07B2200/11 , C12Q1/6837 , C12Q1/689 , C40B20/02 , C40B50/14 , Y02A50/58 , C12Q2565/513 , C12Q2561/125
摘要： The present invention describes a method for identifying one or more of a plurality of sequences differing by one or more single base changes, insertions, deletions, or translocations in a plurality of target nucleotide sequences. The method includes a ligation phase, a capture phase, and a detection phase. The ligation phase utilizes a ligation detection reaction between one oligonucleotide probe, which has a target sequence-specific portion and an addressable array-specific portion, and a second oligonucleotide probe, having a target sequence-specific portion and a detectable label. After the ligation phase, the capture phase is carried out by hybridizing the ligated oligonucleotide probes to a solid support with an array of immobilized capture oligonucleotides at least some of which are complementary to the addressable array-specific portion. Following completion of the capture phase, a detection phase is carried out to detect the labels of ligated oligonucleotide probes hybridized to the solid support. The ligation phase can be preceded by an amplification process. The present invention also relates to a kit for practicing this method, a method of forming arrays on solid supports, and the supports themselves.
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10.发明授权SYNTHESIS AND USE OF ANTI-REVERSE PHOSPHOROTHIOATE ANALOGS OF THE MESSENGER RNA CAP 有权合成及mRNA的CAP的防逆转硫代磷酸酯类似物的使用
公开(公告)号：EP2167523B1
公开(公告)日：2014-07-23
申请号：EP08771474.7
申请日：2008-06-19
申请人： Board of Supervisors of Louisiana State University and Agricultural and Mechanical College , Uniwersytet Warszawski
发明人： JEMIELITY, Jacek , GRUDZIEN-NOGALSKA, Ewa, M. , KOWALSKA, Joanna , DARZYNKIEWICZ, Edward , RHOADS, Robert, E.
IPC分类号： C07H19/207
CPC分类号： C07H19/207 , C12P19/34 , C12P21/02
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