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公开(公告)号：EP3169697A2
公开(公告)日：2017-05-24
申请号：EP15822758.7
申请日：2015-07-13
发明人： RAGHUWANSHI, Arjun , SINGH, Shrawan Kumar , THAKER, Nidhiben , SHANKAR, Shagun , KARDILE, Pavan , SINGH, Sanjay
IPC分类号： C07K1/14 , C07K14/535 , C12P21/00
CPC分类号： C07K14/535 , A61K9/0019 , A61K38/00 , A61K38/193 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/26 , A61K47/60 , C07K1/02 , C07K1/14 , C07K1/18 , C07K1/34
摘要： The present invention provides a novel, scalable and industrially viable downstream process for purification of recombinant human G-CSF.
摘要翻译： 本发明提供了用于纯化重组人G-CSF的新颖的，可扩展的和工业上可行的下游方法。
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公开(公告)号：EP2654770B1
公开(公告)日：2018-07-11
申请号：EP11851346.4
申请日：2011-12-16
CPC分类号： A61K38/482 , A61K9/0019 , A61K9/19 , A61K47/02 , A61K47/183 , A61K47/26 , C12Y304/21068
摘要： Pharmaceutical compositions of tenecteplase that are safe and effective in the treatment of acute ischemic stroke compared with the known compositions are disclosed. The compositions of the invention are invented based on a series of testing trials on the different amounts of the TNK and isolating specific amount that is optimally suitable in terms of desired effects of TNK in the treatment of acute ischemic stroke.
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公开(公告)号：EP3169697B1
公开(公告)日：2024-10-23
申请号：EP15822758.7
申请日：2015-07-13
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公开(公告)号：EP4392023A1
公开(公告)日：2024-07-03
申请号：EP22860802.2
申请日：2022-08-24
发明人： KAVIRAJ, Swarnendu , SINGH, Sanjay , RAUT, Sunil , KARDILE, Pavan , SINGH, Ajay
IPC分类号： A61K9/19
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5.发明公开
公开(公告)号：EP3209767A4
公开(公告)日：2018-03-07
申请号：EP15852227
申请日：2015-10-19
IPC分类号： C12N1/14
CPC分类号： C12N9/6408
摘要： The present invention relates to a novel process of isolating and purifying tissue plasminogen activator and its variants more specifically TNK-tPA from CHO cells and describes an industrially applicable, simple, cost effective, robust and highly efficient process of TNK-tPA purification.
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6.发明公开A NOVEL PURIFICATION PROCESS FOR ISOLATION AND COMMERCIAL PRODUCTION OF RECOMBINANT TNK-TPA (TENECTEPLASE) 审中-公开用于分离和商业化生产重组TNK-TPA（TENEPEPLASE）的新型纯化方法
公开(公告)号：EP3209767A2
公开(公告)日：2017-08-30
申请号：EP15852227.6
申请日：2015-10-19
IPC分类号： C12N1/14
摘要： The present invention relates to a novel process of isolating and purifying tissue plasminogen activator and its variants more specifically TNK-tPA from CHO cells and describes an industrially applicable, simple, cost effective, robust and highly efficient process of TNK-tPA purification.
摘要翻译： 本发明涉及一种从CHO细胞中分离和纯化组织纤溶酶原激活物及其变体（更特别是TNK-tPA）的新方法，并且描述了TNK-tPA纯化的工业上适用的，简单的，成本有效的，稳健且高效的方法。
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公开(公告)号：EP4351521A1
公开(公告)日：2024-04-17
申请号：EP22841629.3
申请日：2022-07-08
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公开(公告)号：EP3169697A4
公开(公告)日：2017-11-08
申请号：EP15822758
申请日：2015-07-13
发明人： RAGHUWANSHI ARJUN , SINGH SHRAWAN KUMAR , THAKER NIDHIBEN , SHANKAR SHAGUN , KARDILE PAVAN , SINGH SANJAY
IPC分类号： C07K1/14 , C07K14/535 , C12P21/00
CPC分类号： C07K14/535 , A61K9/0019 , A61K38/00 , A61K38/193 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/26 , A61K47/48215 , A61K47/60 , C07K1/02 , C07K1/14 , C07K1/18 , C07K1/34
摘要： The present invention provides a novel, scalable and industrially viable downstream process for purification of recombinant human G-CSF.
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公开(公告)号：EP2654770A4
公开(公告)日：2014-05-21
申请号：EP11851346
申请日：2011-12-16
CPC分类号： A61K38/482 , A61K9/0019 , A61K9/19 , A61K47/02 , A61K47/183 , A61K47/26 , C12Y304/21068
摘要： Pharmaceutical compositions of tenecteplase that are safe and effective in the treatment of acute ischemic stroke compared with the known compositions are disclosed. The compositions of the invention are invented based on a series of testing trials on the different amounts of the TNK and isolating specific amount that is optimally suitable in terms of desired effects of TNK in the treatment of acute ischemic stroke.
摘要翻译： 公开了与已知组合物相比，治疗急性缺血性卒中安非他酮的替奈普酶的药物组合物。 本发明的组合物是基于对TNK的不同量和分离特异性量的一系列测试试验发明的，所述测定试验在TNK治疗急性缺血性卒中的期望作用方面是最佳的。
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