摘要:
A method of reconstructing an (n+l)-dimensional image function f representing a region of investigation (1) comprises the step of determining the image function f from n-dimensional or less dimensional Radon data comprising a plurality of projection functions pθ(t) measured corresponding to a plurality of predetermined projection directions (Θ), wherein the image function f is determined as a sum polynomials multiplied with values of the projection functions pθ(t). An imaging method and an imaging device, like e.g. a computer tomography device, using this reconstruction method are described.
摘要:
A method of correcting detector signals, in particular for scatter noise correction with an projection-based imaging device, comprises the steps of irradiating an object (1) with a radiation beam (2) including at least one discrete beam component (3, 3.1, 3.2) bounded by at least one masked angular range (4, 4.1, 4.2), so that the object (1) is partially irradiated with the beam component (3, 3.1, 3.2), detecting radiation transmitted through the object (1) with a detector device (30) comprising a plurality of detector portions (32, 32.1, 32.2, 33.1, 33.2), wherein direct radiation of the at least one beam component (3) is detected by at least one directly irradiated detector portion (32, 32.1, 32.2), detecting indirect radiation occurring in the at least one masked angular range by at least one masked detector portion (33.1, 33.2) adjacent to the at least one directly irradiated detector portion (32, 32.1, 32.2), and correcting detector signals of the at least one directly irradiated detector portion (32, 32.1, 32.2) in dependence on the at least one detector signal of the at least one masked detector portion (33.1, 33.2) for providing corrected detector signals. Furthermore, an imaging device for projection-based imaging is described.
摘要:
The present invention refers to a newly discovered gene named KASPP for Kinase Associated with Parkinsonism with Pleiomorphic Pathology or alternatively named LRRK2 for Leucine-Rich Repeat Kinase 2, its production, biochemical characterization and use for the detection and treatment of neurodegenerative disorders, such as Parkinson disease (PD) including, without limitation, sporadic PD, Alzheimer disease (AD), amyotrophic lateral sclerosis (ALS), and other synucleinopathies and/or tauopathy as well as several polymorphisms and mutations in the KASPP/LRRK2 gene segregated with PD.
摘要:
The present invention is directed to a conditional gene vector system and to a host cell, which has been transfected with such a vector system. The present invention is further directed to a combined preparation comprising the vector system of the invention and an interfering agent. Furthermore, a pharmaceutical composition and its use in the treatment of hemophilia, diabetes, rheumatoid arthritis, genetic immunodeficiency, and graft versus host disease is provided.
摘要:
The invention relates to a method for enhancing somatic hypermutation, gene conversion and/or immunoglobulin class switch recombination in a cell by increasing the level of an E2A encoded protein in the cell. The invention also relates to cells and cell lines with an increased level of said activities.
摘要:
Novel phenothiazine derivatives and their use in the treatment of diabetes mellitus (type I and type II), and as an ovulation inhibitor (contraceptive), cancer chemotherapeutic and/or prophylactic agent, anti-obesity drug (body weight regulator), and immunostimulant.
摘要:
A dosimeter (10) for measuring doses of ionizing radiation, comprises a carrier (11) supporting an electronic chip (12), and a protecting cover layer (13) arranged on the chip (12), wherein the cover layer (13) contains at least one radiation sensitive material, wherein the radiation sensitive material comprises a phosphor substance adapted for thermo-luminescence measurements. Furthermore, a method of measuring doses of ionizing radiation are described.
摘要:
The present invention is directed to a screening method for testing the efficacy of a vaccine, i.e. in order to allow the determination of the protective capacity of a specific antigen. The present invention further pertains to an antigen or a vaccine identified by this screening method.
摘要:
The present invention relates to a novel class of gene trap vector (enhanced gene trap vectors, eGTV) for efficiently identifying silent or weakly expressed target genes in mammalian genomes, methods of their production and methods for identifying and mutating target genes by using the enhanced gene trap vectors. The gene trap vectors of the present invention can also be used for inducing the expression of silent genes and enhancing the expression of weakly expressed genes. The use of the enhanced gene trap vectors for creating transgenic organisms to identify gene function and to validate pharmaceutical compounds prior to clinical applications is a further aspect of the present invention.