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10 条记录 (耗时 0.012 秒)

    Catalytic nucleic acid and its medical use
    1.
    发明公开
    Catalytic nucleic acid and its medical use 失效
    KatalytischeNukleinsäureund deren medizinische Verwendung

    公开(公告)号：EP1350854A1

    公开(公告)日：2003-10-08

    申请号：EP03008821.5

    申请日：1997-08-26

    申请人： Intelligene Ltd.

    发明人： Asher, Nathan Givat Sharett ,  Ellington, Andy ,  Tikochinski, Yaron

    IPC分类号： C12Q1/68 ,  C12N15/11

    CPC分类号： C12N15/113 ,  C07K2319/00 ,  C12N15/1048 ,  C12N2310/124 ,  C12Q1/6811 ,  C12Q2521/337

    摘要： The present invention concerns nucleic acid molecules, or complex of molecules, which have no catalytic activity in the absence of a specific co-factor, and feature catalytic activity only in the presence of a specific co-factor. The present invention further concerns methods for the production of said molecules, or complex of molecules, particularly utilizing in vitro evolution, as well as their usage in diagnostics and therapeutics.

    摘要翻译： 本发明涉及核酸分子或分子复合物，其在不存在特定辅助因子的情况下不具有催化活性，并且仅在特定辅助因子存在下具有催化活性。 本发明还涉及生产所述分子或分子复合物的方法，特别是利用体外进化，以及它们在诊断和治疗中的应用。

    DETECTION OF NUCLEIC ACID SEQUENCES
    4.
    发明公开
    DETECTION OF NUCLEIC ACID SEQUENCES 失效
    测定NUCLEIC序列的

    公开(公告)号：EP0710292A4

    公开(公告)日：1999-05-19

    申请号：EP94919280

    申请日：1994-06-02

    申请人： INTELLIGENE LTD

    发明人： NATHAN ASHER

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6865 ,  C12Q1/6813 ,  C12Q1/6848 ,  C12Q1/6862 ,  C12Q2527/107 ,  C12Q2521/501

    摘要： A method for detecting the presence of an assayed nucleic acid sequence in a sample is an essentially two-stage procedure. In a first stage the sample is reacted in a manner which gives rise to the production of a triggering RNA where the sample contains the assayed sequence. In the second stage, the reaction product is incubated under appropriate conditions with an amplification reagent ensemble whereby, in the presence of triggering RNA a large amount of a nucleic acid product is obtained. The detection of this product thus indicates the presence of the assayed sequence in the sample.

    RIBOZYMES USED AS PRODRUGS
    5.
    发明公开
    RIBOZYMES USED AS PRODRUGS 审中-公开
    RIBOZYME ALS PRODROGEN

    公开(公告)号：EP1123113A1

    公开(公告)日：2001-08-16

    申请号：EP99952769.0

    申请日：1999-10-22

    申请人： Intelligene Ltd.

    发明人： NATHAN, Asher

    IPC分类号： A61K47/48

    CPC分类号： A61K47/6901

    摘要： The invention concerns prodrugs wherein the drug converts from its active form to its inactive form due to catalytic activity of nucleic acid sequences associated with the prodrug.

    DETECTION OF NUCLEIC ACID SEQUENCES
    7.
    发明公开
    DETECTION OF NUCLEIC ACID SEQUENCES 失效
    测定NUCLEIC序列的

    公开(公告)号：EP0710292A1

    公开(公告)日：1996-05-08

    申请号：EP94919280.0

    申请日：1994-06-02

    申请人： Intelligene Ltd.

    发明人： Nathan, Asher

    IPC分类号： C12Q1

    CPC分类号： C12Q1/6865 ,  C12Q1/6813 ,  C12Q1/6848 ,  C12Q1/6862 ,  C12Q2527/107 ,  C12Q2521/501

    摘要： A method for detecting the presence of an assayed nucleic acid sequence in a sample is an essentially two-stage procedure. In a first stage the sample is reacted in a manner which gives rise to the production of a triggering RNA where the sample contains the assayed sequence. In the second stage, the reaction product is incubated under appropriate conditions with an amplification reagent ensemble whereby, in the presence of triggering RNA a large amount of a nucleic acid product is obtained. The detection of this product thus indicates the presence of the assayed sequence in the sample.