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公开(公告)号：EP1846757B1
公开(公告)日：2020-04-08
申请号：EP06706558.1
申请日：2006-02-01
申请人： Metanomics GmbH
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公开(公告)号：EP1774004B1
公开(公告)日：2013-07-10
申请号：EP05771370.3
申请日：2005-07-21
申请人： Metanomics GmbH
发明人： PUZIO, Piotr , CHARDONNENS, Agnes
IPC分类号： C12N15/82
CPC分类号： C12N15/8216 , C07K14/395 , C07K14/415 , C12N15/8217 , C12N15/8261 , Y02A40/146
摘要： A method for preparing a nonhuman organism with faster growth and/or increased yield in comparison with a reference organism, with method comprises increasing the activity of SEQ ID NO: 2, 107, 125, 129 or 137 in said organism or in one or parts thereof in comparison with a reference organism.
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公开(公告)号：EP2368905A3
公开(公告)日：2012-08-29
申请号：EP11161547.2
申请日：2005-12-19
申请人： Metanomics GmbH
发明人： Puzio, Piotr , Blau, Astrid , Plesch, Gunnar , Kamlage, Beate , Looser, Ralf , Schmitz, Oliver , Wendel, Birgit
IPC分类号： C07K14/425 , C07K14/395 , C12P1/00 , C12P23/00 , C12Q1/68 , C12N15/82
CPC分类号： C07K14/425 , C12N15/825 , C12P23/00 , C12Q1/6895
摘要： The present invention relates to a process for the control of the production of fine chemical in a microorganism, a plant cell, a plant, a plant tissue or in one or more parts thereof. The invention furthermore relates to nucleic acid molecules, polypeptides, nucleic acid constructs, vectors, antisense molecules, antibodies, host cells, plant tissue, propagation material, harvested material, plants, microorganisms as well as agricultural compositions and to their use.
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公开(公告)号：EP2369346A3
公开(公告)日：2011-11-02
申请号：EP10196643.0
申请日：2007-03-21
申请人： Metanomics GmbH
发明人： Bethan, Bianca , Busch, Kristina , Wiemer, Jan , Gipmans, Martijn , Leibold, Edgar , Spranger, Jochen , Bobbert, Thomas , Pfeiffer, Andreas Friedrich Hermann
CPC分类号： G01N33/92 , G01N33/6848 , G01N33/6893 , G01N2800/042 , G01N2800/52 , Y10T436/144444 , Y10T436/24
摘要： The present invention relates to a method for diagnosing diabetes or a predisposition thereof comprising determining at least one metabolite in a test sample of a subject suspected to suffer from diabetes or to have a predisposition therefor and comparing said at least one metabolite to a reference, whereby diabetes or a predisposition therefor is to be diagnosed. Moreover, the present invention encompasses a collection of metabolites, a data collection comprising characteristic values of metabolites and a storage medium comprising said data collection. Furthermore, the present invention also relates to a system comprising means for comparing characteristic values of metabolites of a sample operatively linked to a data storage medium. Further encompassed by the present invention are diagnostic means comprising at least one metabolite and the use of said at least one metabolite for the manufacture of diagnostic means for diagnosing diabetes. Finally, the present invention pertains to a method for identifying diabetes-related metabolites.
摘要翻译： 本发明涉及用于诊断糖尿病或其倾向性的方法，其包括测定怀疑患有糖尿病或具有倾向性的受试者的测试样品中的至少一种代谢物，并将所述至少一种代谢物与参照进行比较，由此 糖尿病或其易感性被诊断。 此外，本发明包括代谢物的集合，包含代谢物的特征值的数据集合和包含所述数据集合的存储介质。 此外，本发明还涉及一种系统，其包括用于比较可操作地连接到数据存储介质的样品的代谢物的特征值的装置。 本发明还包括包含至少一种代谢产物的诊断手段和所述至少一种代谢产物在制造用于诊断糖尿病的诊断手段中的用途。 最后，本发明涉及鉴定糖尿病相关代谢物的方法。
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公开(公告)号：EP2336782A1
公开(公告)日：2011-06-22
申请号：EP10196649.7
申请日：2007-03-21
申请人： Metanomics GmbH
发明人： Bethan, Bianca , Busch, Kristina , Wiemer, Jan , Gipmans, Martijn , Leibold, Edgar , Spranger, Jochen , Bobbert, Thomas , Pfeiffer, Andreas Friedrich Hermann
CPC分类号： G01N33/92 , G01N33/6848 , G01N33/6893 , G01N2800/042 , G01N2800/52 , Y10T436/144444 , Y10T436/24
摘要： The present invention relates to a method for diagnosing a predisposition for diabetes comprising determining at least one metabolite in a test sample of a subject suspected to have a predisposition for diabetes and comparing said at least one metabolite to a reference, whereby a predisposition for diabetes is to be diagnosed. Moreover, the present invention encompasses a collection of metabolites, a data collection comprising characteristic values of metabolites and a storage medium comprising said data collection. Furthermore, the present invention also relates to a system comprising means for comparing characteristic values of metabolites of a sample operatively linked to a data storage medium. Further encompassed by the present invention are diagnostic means comprising at least one metabolite and the use of said at least one metabolite for the manufacture of diagnostic means for diagnosing a predisposition for diabetes. Finally, the present invention pertains to a method for identifying diabetes-related metabolites.
摘要翻译： 本发明涉及一种用于诊断糖尿病倾向的方法，包括测定疑似患有糖尿病倾向的对象的测试样品中的至少一种代谢物，并将所述至少一种代谢物与参考对比，由此糖尿病的倾向是 被诊断。 此外，本发明包括代谢物的集合，包括代谢物的特征值的数据收集和包含所述数据收集的存储介质。 此外，本发明还涉及一种系统，其包括用于比较可操作地连接到数据存储介质的样品的代谢物的特征值的装置。 本发明进一步包括的是包含至少一种代谢物和所述至少一种代谢物用于制造用于诊断糖尿病倾向的诊断装置的诊断装置。 最后，本发明涉及鉴定糖尿病相关代谢物的方法。
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公开(公告)号：EP2330423A1
公开(公告)日：2011-06-08
申请号：EP10196430.2
申请日：2007-03-21
申请人： Metanomics GmbH
发明人： Bethan, Bianca , Busch, Kristina , Wiemer, Jan , Gipmans, Martijn , Leibold, Edgar , Spranger, Jochen , Bobbert, Thomas , Pfeiffer, Andreas Friedrich Hermann
CPC分类号： G01N33/92 , G01N33/6848 , G01N33/6893 , G01N2800/042 , G01N2800/52 , Y10T436/144444 , Y10T436/24
摘要： The present invention relates to a method for diagnosing diabetes or a predisposition thereof comprising determining at least one metabolite in a test sample of a subject suspected to suffer from diabetes or to have a predisposition therefor and comparing said at least one metabolite to a reference, whereby diabetes or a predisposition therefor is to be diagnosed. Moreover, the present invention encompasses a collection of metabolites, a data collection comprising characteristic values of metabolites and a storage medium comprising said data collection. Furthermore, the present invention also relates to a system comprising means for comparing characteristic values of metabolites of a sample operatively linked to a data storage medium. Further encompassed by the present invention are diagnostic means comprising at least one metabolite and the use of said at least one metabolite for the manufacture of diagnostic means for diagnosing diabetes. Finally, the present invention pertains to a method for identifying diabetes-related metabolites.
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公开(公告)号：EP2008108B1
公开(公告)日：2010-12-29
申请号：EP07727168.2
申请日：2007-03-21
申请人： Metanomics GmbH
发明人： BETHAN, Bianca , BUSCH, Kristina , WIEMER, Jan , GIPMANS, Martijn , LEIBOLD, Edgar , SPRANGER, Jochen , BOBBERT, Thomas , PFEIFFER, Andreas Friedrich Hermann
CPC分类号： G01N33/92 , G01N33/6848 , G01N33/6893 , G01N2800/042 , G01N2800/52 , Y10T436/144444 , Y10T436/24
摘要： The present invention relates to a method for diagnosing a predisposition for diabetes comprising determining at least one metabolite in a test sample of a subject suspected to have a predisposition for diabetes and comparing said at least one metabolite to a reference, whereby a predisposition for diabetes is to be diagnosed. Moreover, the present invention encompasses a collection of metabolites, a data collection comprising characteristic values of metabolites and a storage medium comprising said data collection. Furthermore, the present invention also relates to a system comprising means for comparing characteristic values of metabolites of a sample operatively linked to a data storage medium. Further encompassed by the present invention are diagnostic means comprising at least one metabolite and the use of said at least one metabolite for the manufacture of diagnostic means for diagnosing a predisposition for diabetes. Finally, the present invention pertains to a method for identifying diabetes- related metabolites.
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公开(公告)号：EP2175034A2
公开(公告)日：2010-04-14
申请号：EP09156455.9
申请日：2006-09-06
申请人： Metanomics GmbH
发明人： Puzio, Piotr , Wendel, Birgit , Herold, Michael Manfred , Looser, Ralf , Blau, Astrid , Plesch, Gunnar , Kamlage, Beate , Schauwecker, Florian
CPC分类号： C12N15/8214 , C12N15/8221 , C12N15/8243 , C12N15/8245 , C12N15/8247 , C12N15/825 , C12N15/8251 , C12N15/8253 , C12N15/8254 , C12P7/64 , C12P13/06 , C12P13/10 , C12P13/12
摘要： The present invention relates to a process for the production of the fine chemical in a microorganism, a plant cell, a plant, a plant tissue or in one or more parts thereof, preferably in plastids. The invention furthermore relates to nucleic acid molecules, polypeptides, nucleic acid constructs, vectors, antibodies, host cells, plant tissue, propagation material, harvested material, plants, microorganisms as well as agricultural compositions and to their use.
摘要翻译： 本发明涉及在微生物，植物细胞，植物，植物组织或其一个或多个部分，优选在质体中生产精细化学品的方法。 本发明还涉及核酸分子，多肽，核酸构建体，载体，抗体，宿主细胞，植物组织，繁殖材料，收获材料，植物，微生物以及农业组合物及其用途。
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公开(公告)号：EP2096177A3
公开(公告)日：2010-01-13
申请号：EP09156646.3
申请日：2005-12-19
申请人： Metanomics GmbH
发明人： Puzio, Piotr , Blau, Astrid , Plesch, Gunnar , Kamlage, Beate , Looser, Ralf , Schmitz, Oliver , Wendel, Birgit
CPC分类号： C12N15/825 , C07K14/425 , C12P23/00 , C12Q1/6895
摘要： The present invention relates further to a process for the control of the production of fine chemical in a microorganism, a plant cell, a plant, a plant tissue or in one or more parts thereof. The invention furthermore relates to nucleic acid molecules, polypeptides, nucleic acid constructs, vectors, antisense molecules, antibodies, host cells, plant tissue, propagation material, harvested material, plants, microorganisms as well as agricultural compositions and to their use.
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公开(公告)号：EP2118650A1
公开(公告)日：2009-11-18
申请号：EP08702074.9
申请日：2008-02-06
申请人： Metanomics GmbH
发明人： BEATE, Kamlage , BLASING, Oliver , GIBON, Yves , STITT, Mark
CPC分类号： A01H1/04 , A01H1/02 , G01N33/5023 , G01N33/5097 , G01N2333/415
摘要： A process for identifying whether plant is resistant to chilling comprises cultivating the plant at a reduced temperature for a time period selected from short term and medium term; harvesting a tissue sample of the plant; measuring concentration of at least one metabolite in the tissue sample of the plant; comparing the measured concentration with the concentration of the same metabolite in a tissue sample harvested from a reference plant or a plant of the same species after cultivation at a reference temperature; and optionally, repeating the process of foregoing steps but cultivating the plant at a reduced temperature for a time period selected from short term and medium term and not previously used; wherein resistance to chilling is indicated by one or more of the effects on metabolites listed in Table 2 or Table 4.
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