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公开(公告)号：EP1773762A2
公开(公告)日：2007-04-18
申请号：EP05758946.7
申请日：2005-07-07
发明人： ZIV, Ilan , SHIRVAN, Anat
IPC分类号： C07C303/00 , C07C307/00 , C07C309/00 , C07C311/00
CPC分类号： C07C323/49 , A61K51/0406 , C07B2200/05 , C07C323/03 , G01N33/5005 , G01N33/5091 , G01N33/6896 , G01N2800/2821
摘要： The invention provides methods for detection of medical disorders, associated with cellular oxidative stress, cell degeneration and / or cell death. The invention further relates to compounds comprising a thiol (-SH) group, for detecting cells undergoing oxidative stress, degeneration and / or a death process. The invention further provides methods for utilizing the compounds in medical practice, for diagnostic and therapeutic purposes.
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公开(公告)号：EP1773762A4
公开(公告)日：2008-12-10
申请号：EP05758946
申请日：2005-07-07
发明人： ZIV ILAN , SHIRVAN ANAT
IPC分类号： C07C303/00 , C07C307/00 , C07C309/00 , C07C311/00 , G01N33/50 , G01N33/68
CPC分类号： C07C323/49 , A61K51/0406 , C07B2200/05 , C07C323/03 , G01N33/5005 , G01N33/5091 , G01N33/6896 , G01N2800/2821
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3.发明公开METHOD FOR SELECTIVE TARGETING OF APOPTOTIC CELLS AND SMALL MOLECULE LIGANDS USED THEREOF 审中-公开PROCESS FOR凋亡细胞和组合使用的小分子配体的选择性靶向
公开(公告)号：EP1643958A2
公开(公告)日：2006-04-12
申请号：EP04737002.8
申请日：2004-06-17
发明人： ZIV, Ilan , SHIRVAN, Anat
IPC分类号： A61K6/00
CPC分类号： A61K31/198 , A61K49/0002 , A61K49/0021 , A61K51/0497 , C07C229/36 , C07C309/47 , C07C311/42 , C07C323/57
摘要： The invention provides novel methods for selective targeting of chemical compounds to cells undergoing a death process, in particular apoptosis, and to platelets undergoing activation during blood coagulation. The invention further provides compounds to be used in said methods for medical practice, for diagnostic and therapeutic purposes.
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公开(公告)号：EP1729820A4
公开(公告)日：2009-11-11
申请号：EP05703098
申请日：2005-01-16
发明人： ZIV ILAN , SHIRVAN ANAT
CPC分类号： C07F13/005 , A61K49/0002 , A61K51/04
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公开(公告)号：EP1729820A2
公开(公告)日：2006-12-13
申请号：EP05703098.3
申请日：2005-01-16
发明人： ZIV, Ilan , SHIRVAN, Anat
CPC分类号： C07F13/005 , A61K49/0002 , A61K51/04
摘要： The present invention relates to compounds that selectively bind to cells undergoing perturbations and alterations of their normal plasma membrane organization, such as cells undergoing apoptosis or activated platelets. The invention further provides methods for utilizing said compounds in medical practice, for diagnostic and therapeutic purposes.
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公开(公告)号：EP1107985A1
公开(公告)日：2001-06-20
申请号：EP99939587.4
申请日：1999-08-23
发明人： ZIV, Ilan , SHIRVAN, Anat
CPC分类号： C07K14/4721
摘要： The present invention relates to an NST300 compound of general formula (I): comprising the following components: X1 - [(X3)a / (X4)b] in which X1 represents a fatty acid or prenyl group; and X3 represents a domain of positively charged amino acids; and X4 represents a domain containing aromatic amino acids; and a stands for an integer of 1-8; and b stands for an integer of 1-8. The invention relates also to pharmaceutical compositions comprising a compound of general formula (I), the use of said compound and of said pharmaceutical composition in the preparation of a medicament and in methods for the treatment or prevention of prothrombic states in disorders which are associated with excessive procoagulant activity, initiated or propagated by CMLA loss. The invention relates also to the use of said compound and of said pharmaceutical composition for the diagnosis of CMLA loss; as a targeting agent; as targeting drugs to tissues inflicted by CMLA loss; and for basic research in fields of research in which CMLA loss takes place both in vitro and in vivo.
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7.发明公开METHOD FOR SELECTIVE TARGETING OF APOPTOTIC CELLS AND SMALL MOLECULE LIGANDS USED THEREOF 审中-公开PROCESS FOR凋亡细胞和组合使用的小分子配体的选择性靶向
公开(公告)号：EP1643958A4
公开(公告)日：2010-09-01
申请号：EP04737002
申请日：2004-06-17
发明人： ZIV ILAN , SHIRVAN ANAT
IPC分类号： A61K31/195 , A61K20060101 , A61K31/18 , A61K31/198 , A61K49/00 , A61K49/06 , A61K51/00 , A61K51/04 , C07C229/36 , C07C309/00 , C07C309/47 , C07C311/42 , C07C323/57
CPC分类号： A61K31/198 , A61K49/0002 , A61K49/0021 , A61K51/0497 , C07C229/36 , C07C309/47 , C07C311/42 , C07C323/57
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8.发明公开
公开(公告)号：EP1641742A4
公开(公告)日：2006-11-29
申请号：EP04730796
申请日：2004-05-02
发明人： SHIRVAN ANAT , ZIV ILAN
IPC分类号： C07C229/00 , A61K20060101 , C07C57/34 , C07C59/76 , C07C63/36 , C07C229/36 , C07C311/42 , C07F13/00 , G01N33/569
CPC分类号： G01N33/56966 , A61K31/195 , A61K31/555 , A61K47/54 , A61K49/0002 , A61K51/04 , C07C229/36 , C07C311/42 , C07F13/005 , G01N2800/52
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公开(公告)号：EP1546092A2
公开(公告)日：2005-06-29
申请号：EP03725577.5
申请日：2003-06-03
发明人： ZIV, Ilan , SHIRVAN, Anat , EBNER, Sharon
IPC分类号： C07C311/42 , C07C323/58 , C07C323/25 , A61K49/06 , A61K51/04
CPC分类号： A61K49/0002 , A61K49/06 , A61K51/0478 , C07C311/42 , C07C323/25 , C07C323/58
摘要： The present invention provides novel compounds that bind selectively to cells undergoing perturbations and alterations of the normal organization of their plasma membrane, while binding to a lesser degree to cells having membranes of normal organization, and their uses as diagnostic probes. Said compounds and methods used therein may be useful in medical practice, for applications such as diagnosis of disease and monitoring of response to therapy.
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公开(公告)号：EP1406664A2
公开(公告)日：2004-04-14
申请号：EP02713081.4
申请日：2002-03-14
发明人： ZIV, Ilan , SHIRVAN, Anat , EBNER, Sharon
CPC分类号： A61K31/198
摘要： The present invention concerns a method for selectively targeting a medicinally-useful agent into cells in which a phospholipid scramblase (PLS) transport system is activated. The method comprises administering the agent, being a PLS-dependent transported compound (PDTC) to the cells, thereby causing selective transport of the agent into the cells. Examples of the cells are apoptotic cells, activated cells and injured cells. Also disclosed are pharmaceutical compositions for use by the method.
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