公开(公告)号：EP1041970B1

公开(公告)日：2013-07-03

申请号：EP98952952.4

申请日：1998-10-23

申请人： Polyheal Ltd.

发明人： RITTER, Vladimir ,  RITTER, Marina

IPC分类号： A61K9/14 ,  A61K9/16 ,  A61L24/00 ,  A61L24/04 ,  A61L24/06

CPC分类号： A61L24/046 ,  A61K9/1635 ,  A61K9/1641 ,  A61L24/001 ,  A61L24/0015 ,  A61L24/06 ,  A61L2300/622 ,  C08L83/04 ,  C08L77/04 ,  C08L39/00 ,  C08L33/12 ,  C08L25/06

公开(公告)号：EP1545412A1

公开(公告)日：2005-06-29

申请号：EP03774464.6

申请日：2003-09-04

申请人： Polyheal Ltd.

发明人： RITTER, Vladimir ,  RITTER, Marina ,  TENDLER, Mark ,  FEITELBERG, Lev

IPC分类号： A61F13/00 ,  A61F2/00

CPC分类号： A61K9/1635

摘要： The present invention relates to compositions of microspheres suitable for application to ocular injuries and inflammation, and to methods of use of the compositions alone or in combination with other agents in the prevention and treatment of ocular injuries and inflammation. The compositions, which increase the rate of healing, can be used to treat injuries and inflammation , including but not limited to those caused by foreign bodies, infections, burns, lesions, lacerations, ischemia, injuries from blunt trauma, traumatic hyphema, sympathetic ophthalmia, injuries from radiant energy, cataracts, corneal erosions or optic nerve injuries, and in procedures such as post-trabeculectomy (filtering surgery), post pterygium surgery; post ocular adnexa trauma and surgery, post intraocular surgery, post vitrectomy, post retinal detachment or post retinotomylectomy.

公开(公告)号：EP2895209A4

公开(公告)日：2016-04-20

申请号：EP13838041

申请日：2013-09-12

申请人： POLYHEAL LTD

发明人： RITTER VLADIMIR ,  KLEYMAN MERY ,  BARTFELD DEBORAH HANAH ,  ASCULAI EILON

IPC分类号： A61L26/00 ,  A61K9/16 ,  A61P17/02

CPC分类号： A61K31/745 ,  A61K9/16 ,  A61K9/1617 ,  A61L26/0014 ,  A61L26/0061 ,  C08L25/06

摘要： Pharmaceutical or medical compositions for treating a wound are provided, the composition comprise microspheres as an active ingredient and water as a carrier for said microspheres. In some embodiments, compositions comprising a thickening agent dissolved within the water to form a solution having a specific gravity similar to that of the microspheres are provided.

公开(公告)号：EP1041970A4

公开(公告)日：2006-03-22

申请号：EP98952952

申请日：1998-10-23

申请人： POLYHEAL LTD

发明人： RITTER VLADIMIR ,  RITTER MARINA

IPC分类号： A61K9/10 ,  A61K9/06 ,  A61K9/12 ,  A61K9/16 ,  A61K9/50 ,  A61K9/70 ,  A61K31/137 ,  A61K31/167 ,  A61K31/198 ,  A61K31/245 ,  A61K31/352 ,  A61K31/445 ,  A61K31/485 ,  A61K31/65 ,  A61K31/7036 ,  A61K31/728 ,  A61K33/00 ,  A61K33/06 ,  A61K33/24 ,  A61K33/26 ,  A61K33/30 ,  A61K33/32 ,  A61K33/34 ,  A61K35/26 ,  A61K38/00 ,  A61K38/04 ,  A61K38/17 ,  A61K47/30 ,  A61K47/32 ,  A61K47/42 ,  A61L24/00 ,  A61L24/04 ,  A61L24/06 ,  A61P1/02 ,  A61P17/00 ,  A61P17/02 ,  A61K9/14

CPC分类号： A61L24/046 ,  A61K9/1635 ,  A61K9/1641 ,  A61L24/001 ,  A61L24/0015 ,  A61L24/06 ,  A61L2300/622 ,  C08L83/04 ,  C08L77/04 ,  C08L39/00 ,  C08L33/12 ,  C08L25/06

公开(公告)号：EP0988029A4

公开(公告)日：2001-02-21

申请号：EP98924538

申请日：1998-06-04

申请人： POLYHEAL LTD

发明人： RITTER VLADIMIR

IPC分类号： A61K9/50 ,  A61K9/06 ,  A61K9/16 ,  A61K9/51 ,  A61K47/32 ,  A61K47/38 ,  A61K47/42 ,  A61L15/44 ,  A61L26/00 ,  A61P17/02 ,  B41J2/16 ,  H05K1/00 ,  H05K3/00 ,  H05K3/28 ,  H05K3/38

CPC分类号： A61L26/0076 ,  A61K9/167 ,  A61L15/44 ,  A61L26/0014 ,  A61L26/0019 ,  A61L26/0061 ,  A61L2300/402 ,  A61L2300/406 ,  A61L2300/414 ,  A61L2300/622 ,  A61L2300/64 ,  B41J2/1601 ,  B41J2/1623 ,  B41J2/164 ,  B41J2002/14362 ,  H05K1/0393 ,  H05K3/0058 ,  H05K3/281 ,  H05K3/386 ,  Y10S514/866 ,  C08L39/08 ,  C08L25/04 ,  C08L33/12 ,  C08L77/04

摘要： A method and a device for the treatment of wounds and promotion of wound healing and muscle regeneration. The method includes applying a composition including a non-biodegradable microsphere with a substantial surface charge to the subject. The device further includes a pharmaceutically acceptable carrier and a container for containing the composition and the carrier. The microspheres used in the present invention have been shown to promote wound healing and muscle regeneration both in vivo and in vitro.

摘要翻译： 一种用于治疗伤口并促进伤口愈合和肌肉再生的方法和装置。 该方法包括将包含具有大量表面电荷的不可生物降解的微球体的组合物施用于受试者。 该装置还包括药学上可接受的载体和用于容纳组合物和载体的容器。 已经显示本发明中使用的微球在体内和体外均促进伤口愈合和肌肉再生。

公开(公告)号：EP0988029A1

公开(公告)日：2000-03-29

申请号：EP98924538.6

申请日：1998-06-04

申请人： Polyheal Ltd.

发明人： RITTER, Vladimir

IPC分类号： A61K9/50

CPC分类号： A61L26/0076 ,  A61K9/167 ,  A61L15/44 ,  A61L26/0014 ,  A61L26/0019 ,  A61L26/0061 ,  A61L2300/402 ,  A61L2300/406 ,  A61L2300/414 ,  A61L2300/622 ,  A61L2300/64 ,  B41J2/1601 ,  B41J2/1623 ,  B41J2/164 ,  B41J2002/14362 ,  H05K1/0393 ,  H05K3/0058 ,  H05K3/281 ,  H05K3/386 ,  Y10S514/866 ,  C08L39/08 ,  C08L25/04 ,  C08L33/12 ,  C08L77/04

摘要： A method and a device for the treatment of wounds and promotion of wound healing and muscle regeneration. The method includes applying a composition including a non-biodegradable microsphere with a substantial surface charge to the subject. The device further includes a pharmaceutically acceptable carrier and a container for containing the composition and the carrier. The microspheres used in the present invention have been shown to promote wound healing and muscle regeneration both in vivo and in vitro.

公开(公告)号：EP2895209B1

公开(公告)日：2019-07-17

申请号：EP13838041.5

申请日：2013-09-12

申请人： Polyheal Ltd.

发明人： RITTER, Vladimir ,  KLEYMAN, Mery ,  BARTFELD, Deborah Hanah ,  ASCULAI, Eilon

IPC分类号： A61L26/00 ,  A61K9/16 ,  A61P17/02

公开(公告)号：EP2895209A1

公开(公告)日：2015-07-22

申请号：EP13838041.5

申请日：2013-09-12

申请人： Polyheal Ltd.

发明人： RITTER, Vladimir ,  KLEYMAN, Mery ,  BARTFELD, Deborah Hanah ,  ASCULAI, Eilon

IPC分类号： A61L26/00 ,  A61K9/16 ,  A61P17/02

CPC分类号： A61K31/745 ,  A61K9/16 ,  A61K9/1617 ,  A61L26/0014 ,  A61L26/0061 ,  C08L25/06

摘要： Pharmaceutical or medical compositions for treating a wound are provided, the composition comprise microspheres as an active ingredient and water as a carrier for said microspheres. In some embodiments, compositions comprising a thickening agent dissolved within the water to form a solution having a specific gravity similar to that of the microspheres are provided.

公开(公告)号：EP0988029B1

公开(公告)日：2005-04-06

申请号：EP98924538.6

申请日：1998-06-04

申请人： Polyheal Ltd.

发明人： RITTER, Vladimir

IPC分类号： A61K9/50 ,  A61P17/02

CPC分类号： A61L26/0076 ,  A61K9/167 ,  A61L15/44 ,  A61L26/0014 ,  A61L26/0019 ,  A61L26/0061 ,  A61L2300/402 ,  A61L2300/406 ,  A61L2300/414 ,  A61L2300/622 ,  A61L2300/64 ,  B41J2/1601 ,  B41J2/1623 ,  B41J2/164 ,  B41J2002/14362 ,  H05K1/0393 ,  H05K3/0058 ,  H05K3/281 ,  H05K3/386 ,  Y10S514/866 ,  C08L39/08 ,  C08L25/04 ,  C08L33/12 ,  C08L77/04

摘要： A method and a device for the treatment of wounds and promotion of wound healing and muscle regeneration. The method includes applying a composition including a non-biodegradable microsphere with a substantial surface charge to the subject. The device further includes a pharmaceutically acceptable carrier and a container for containing the composition and the carrier. The microspheres used in the present invention have been shown to promote wound healing and muscle regeneration both in vivo and in vitro.

摘要翻译： 一种用于治疗伤口并促进伤口愈合和肌肉再生的方法和装置。 该方法包括将包含具有大量表面电荷的不可生物降解的微球体的组合物施用于受试者。 该装置还包括药学上可接受的载体和用于容纳组合物和载体的容器。 已经显示本发明中使用的微球在体内和体外均促进伤口愈合和肌肉再生。

公开(公告)号：EP1041970A1

公开(公告)日：2000-10-11

申请号：EP98952952.4

申请日：1998-10-23

申请人： Polyheal Ltd.

发明人： RITTER, Vladimir ,  RITTER, Marina

IPC分类号： A61K9/14

CPC分类号： A61L24/046 ,  A61K9/1635 ,  A61K9/1641 ,  A61L24/001 ,  A61L24/0015 ,  A61L24/06 ,  A61L2300/622 ,  C08L83/04 ,  C08L77/04 ,  C08L39/00 ,  C08L33/12 ,  C08L25/06

摘要： Therapeutic compositions of microspheres for application to wounds and/or lesions for accelerating wound healing and muscle regeneration. The microspheres are made up of non-biodegradable material having a substantial surface charge. The therapeutic composition further includes a pharmaceutically acceptable carrier in which the microspheres are insoluble and a container for holding the composition. The therapeutic composition further contains pharmacologic agents or biologics that accelerate the wound healing process.