公开(公告)号：EP0832203A1

公开(公告)日：1998-04-01

申请号：EP96918000.0

申请日：1996-06-06

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： MAJOR, Eugene, O. ,  TORNATORE, Carlo, S. ,  YADID, Gal

IPC分类号： C12N15 ,  A61K31 ,  A61K35 ,  A61K38 ,  A61K48 ,  A61P25 ,  C12N5 ,  C12N9

CPC分类号： C12N9/0071 ,  A61K35/30 ,  A61K35/54 ,  A61K38/00 ,  A61K48/00 ,  A61K2035/126 ,  C12N5/0622 ,  C12N15/85 ,  C12N2510/04 ,  C12N2800/108 ,  C12N2830/42 ,  C12Y114/13041 ,  C12Y114/16002

摘要： The present invention generally relates to methods for treating a host by implanting genetically unrelated cells in the host. More particularly, the present invention provides human fetal neuro-derived cell lines, and methods of treating a host by implantation of these immortalized human fetal neuro-derived cells into the host.

公开(公告)号：EP0696205B1

公开(公告)日：2002-01-23

申请号：EP94912975.3

申请日：1994-04-11

申请人： GOVERNMENT OF THE UNITED STATES OF AMERICA, as repr. by THE SECR. OF THE DEPT. OF HEALTH AND HUMAN SERVICES AND HIS SUCCESSORS

发明人： MAJOR, Eugene O. ,  TORNATORE, Carlo S. ,  BANKIEWICZ, Kris

IPC分类号： A61K48/00 ,  A61K35/54

CPC分类号： C12N9/0071 ,  A61K35/30 ,  A61K35/54 ,  A61K38/00 ,  A61K48/00 ,  A61K2035/126 ,  C12N5/0622 ,  C12N15/85 ,  C12N2510/04 ,  C12Y114/13041 ,  C12Y114/16002 ,  Y10S435/948

摘要： Human fetal neuro-derived cell lines are implanted into host tissues. The methods allow for treatment of a variety of neurological disorders and other diseases. A preferred cell line is SVG.

公开(公告)号：EP0832203A4

公开(公告)日：2002-07-17

申请号：EP96918000

申请日：1996-06-06

申请人： US GOV HEALTH & HUMAN SERV

发明人： MAJOR EUGENE O ,  TORNATORE CARLO S ,  YADID GAL

IPC分类号： C12N15/09 ,  A61K31/70 ,  A61K35/12 ,  A61K35/30 ,  A61K35/54 ,  A61K38/44 ,  A61K48/00 ,  A61P25/28 ,  C12N5/073 ,  C12N5/079 ,  C12N5/10 ,  C12N9/02 ,  C12N15/52 ,  C12N15/85 ,  C12N15/00

CPC分类号： C12N9/0071 ,  A61K35/30 ,  A61K35/54 ,  A61K38/00 ,  A61K48/00 ,  A61K2035/126 ,  C12N5/0622 ,  C12N15/85 ,  C12N2510/04 ,  C12N2800/108 ,  C12N2830/42 ,  C12Y114/13041 ,  C12Y114/16002

摘要： The present invention generally relates to methods for treating a host by implanting genetically unrelated cells in the host. More particularly, the present invention provides human fetal neuro-derived cell lines, and methods of treating a host by implantation of these immortalized human fetal neuro-derived cells into the host.

公开(公告)号：EP0696205A1

公开(公告)日：1996-02-14

申请号：EP94912975.0

申请日：1994-04-11

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： MAJOR, Eugene O. ,  TORNATORE, Carlo S. ,  BANKIEWICZ, Kris

IPC分类号： C12N15 ,  A61K31 ,  A61K35 ,  A61K38 ,  A61K48 ,  A61P25 ,  C12N5 ,  C12N9

CPC分类号： C12N9/0071 ,  A61K35/30 ,  A61K35/54 ,  A61K38/00 ,  A61K48/00 ,  A61K2035/126 ,  C12N5/0622 ,  C12N15/85 ,  C12N2510/04 ,  C12Y114/13041 ,  C12Y114/16002 ,  Y10S435/948

摘要： Human fetal neuro-derived cell lines are implanted into host tissues. The methods allow for treatment of a variety of neurological disorders and other diseases. A preferred cell line is SVG.

公开(公告)号：EP0734438A4

公开(公告)日：1998-12-23

申请号：EP95907228

申请日：1994-12-19

申请人： SPINAL CORD SOCIETY

发明人： NORNES HOWARD O ,  NEUMAN TOOMAS ,  SUDA KIKUO

IPC分类号： C07K14/075 ,  C07K14/47 ,  C07K14/48 ,  C12N9/02 ,  C12N15/85 ,  C12N15/10 ,  C12N15/64

CPC分类号： C07K14/005 ,  C07K14/4738 ,  C07K14/48 ,  C12N9/0071 ,  C12N15/85 ,  C12N2710/10322 ,  C12Y114/13041 ,  C12Y114/16002

摘要： A method is provided for inducing DNA synthesis in a differentiated neuron, which includes obtaining a vector comprising nucleic acid encoding an E2F regulator and/or an E1A regulator, wherein the vector can be used to express the nucleic acid in a differentiated neuron, and transfecting a differentiated neuron with the vector. According to certain embodiments of the invention, a method for integrating DNA encoding a desired protein in a differentiated neuron is provided that includes obtaining a vector comprising nucleic acid encoding an E2F regulator and/or an E1A regulator, wherein the vector can be used to express the nucleic acid in a neuron, obtaining DNA encoding a desired protein, and cotransfecting a differentiated neuron with the vector and the DNA encoding the desired protein such that the DNA encoding the desired protein is integrated in the differentiated neuron and the desired protein is produced.

公开(公告)号：EP0734438A1

公开(公告)日：1996-10-02

申请号：EP95907228.0

申请日：1994-12-19

申请人： SPINAL CORD SOCIETY

发明人： NORNES, Howard O. ,  NEUMAN, Toomas ,  SUDA, Kikuo

IPC分类号： C07K14 ,  C12N9 ,  C12N15

CPC分类号： C07K14/005 ,  C07K14/4738 ,  C07K14/48 ,  C12N9/0071 ,  C12N15/85 ,  C12N2710/10322 ,  C12Y114/13041 ,  C12Y114/16002

摘要： A method is provided for inducing DNA synthesis in a differentiated neuron, which includes obtaining a vector comprising nucleic acid encoding an E2F regulator and/or an E1A regulator, wherein the vector can be used to express the nucleic acid in a differentiated neuron, and transfecting a differentiated neuron with the vector. According to certain embodiments of the invention, a method for integrating DNA encoding a desired protein in a differentiated neuron is provided that includes obtaining a vector comprising nucleic acid encoding an E2F regulator and/or an E1A regulator, wherein the vector can be used to express the nucleic acid in a neuron, obtaining DNA encoding a desired protein, and cotransfecting a differentiated neuron with the vector and the DNA encoding the desired protein such that the DNA encoding the desired protein is integrated in the differentiated neuron and the desired protein is produced.

公开(公告)号：EP0445218A4

公开(公告)日：1991-11-13

申请号：EP90901107

申请日：1989-10-11

申请人： BAYLOR COLLEGE OF MEDICINE

发明人： LAM, DOMINIC, M.

IPC分类号： C12N15/09 ,  A61K35/12 ,  A61K38/00 ,  C12N5/10 ,  C12N9/02 ,  C12N15/113 ,  C12N15/52 ,  C12N5/18 ,  C12Q1/68

CPC分类号： C12N15/113 ,  A61K38/00 ,  C12N9/0071 ,  C12Y114/13041 ,  C12Y114/16002

摘要： Cells and methods for their preparation are provided, wereby the cells are characterized by being compatible with the central nervous system, being capable of the inducible production and release of neuroactive substances and being mitotically arrested at a predetermined temperature. Drugs can be screened as to their agonistic or antagonistic properties toward production and release of neuroactive substances. In addition, these cells may be used as a source for the neuroactive substances at loci in the central nervous system which are deficient in a particular neuroactive substance and thereby partially or completely alleviate a certain disorder.

公开(公告)号：EP0445218A1

公开(公告)日：1991-09-11

申请号：EP90901107.0

申请日：1989-10-11

申请人： BAYLOR COLLEGE OF MEDICINE

发明人： LAM, Dominic, M.

IPC分类号： C12N15 ,  A61K35 ,  C12N5 ,  C12N9 ,  A61K38

CPC分类号： C12N15/113 ,  A61K38/00 ,  C12N9/0071 ,  C12Y114/13041 ,  C12Y114/16002

摘要： Cette invention concerne des cellules et des méthodes pour leur préparation; lesdites cellules sont caractérisées par leur compatibilité avec le système nerveux central, étant capables de produire et de libérer de manière provoquée des substances neuroactives et étant arrêtées mitotiquement à une température prédéterminée. On peut présélectionner des médicaments pour leurs propriétés agonistes et antagonistes pour la production et la libération de substances neuroactives. Par ailleurs, on peut employer ces cellules en tant que source pour les substances neuroactives en des emplacements dans le système nerveux central qui ont des déficiences d'une substance neuroactive particulière et ainsi soulager partiellement ou complètement un certain trouble.